SMOC1 and TNC

Number of citations: 0 (PubMedID 21349332)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology)

		SMOC1	TNC
Name		SPARC related modular calcium binding 1	tenascin C
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space	Extracellular Region Basement Membrane Interstitial Matrix Extracellular Space Endoplasmic Reticulum Lumen Focal Adhesion Membrane Extracellular Matrix Tenascin Complex Extracellular Matrix Of Synaptic Cleft Perisynaptic Extracellular Matrix Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Protein Binding Heparin Binding Metal Ion Binding Extracellular Matrix Binding	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Syndecan Binding
	Biological Process	Eye Development Cell Differentiation Extracellular Matrix Organization Regulation Of Osteoblast Differentiation Limb Development	Regulation Of Cell Growth Osteoblast Differentiation Morphogenesis Of An Epithelium Cell Adhesion Negative Regulation Of Cell Adhesion Neuromuscular Junction Development Positive Regulation Of Cell Population Proliferation Response To Wounding Response To Mechanical Stimulus Positive Regulation Of Gene Expression Peripheral Nervous System Axon Regeneration Regulation Of Cell Adhesion Regulation Of Cell Migration Neuron Projection Development Odontogenesis Of Dentin-containing Tooth Response To Ethanol Regulation Of Inflammatory Response Bud Outgrowth Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Cellular Response To Retinoic Acid Cellular Response To Vitamin D Response To Fibroblast Growth Factor Cellular Response To Prostaglandin D Stimulus
Pathways		None	Integrin cell surface interactions Syndecan interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
GWAS		Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Bone mineral density ( 24249740 ) Daytime sleep phenotypes ( 27126917 ) Digit length ratio ( 29659830 ) Digit length ratio (left hand) ( 29659830 ) Digit length ratio (right hand) ( 29659830 ) Heel bone mineral density ( 30598549 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 ) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912 ) Peripheral artery disease ( 31285632 ) Red blood cell traits ( 23222517 ) Red cell distribution width ( 27863252 32888494 ) Refractive error ( 32231278 ) Triglyceride levels ( 30108155 ) Tuberculosis ( 24057671 )	Adult body size ( 32376654 ) Appendicular lean mass ( 33097823 ) Developmental language disorder (syntactic complexity) ( 27016271 ) Inflammatory bowel disease ( 23128233 ) Metabolite levels ( 23823483 ) Mosquito bite size ( 28199695 ) Osteoarthritis (hip) ( 30374069 ) Response to bupropion and depression ( 27622933 )
Novel Interactors		3 novel interactors: COX16 SYNJ2BP TTC9	5 novel interactors: ASTN2 ITGB1 POLE3 RAB14 TRIM32
Interacting Genes		10 interacting genes: CYSRT1 KRTAP1-1 KRTAP10-3 KRTAP10-8 NOTCH2NLA NR4A3 SMOC2 TCF4 TNC VGLL3	11 interacting genes: ANXA2 CNTN1 EGFR FN1 ITGA5 MBD1 NCAN PTPRB SMOC1 SMOC2 SPARC
Entrez ID		64093	3371
HPRD ID		12244	01756
Ensembl ID		ENSG00000198732	ENSG00000041982
Uniprot IDs		Q9H4F8	B4E1W8 J3QSU6 P24821
PDB IDs		Not available	1TEN 2RB8 2RBL 5R5T 5R5U 5R5V 5R5W 5R5X 5R5Y 5R5Z 5R60 5R61 5R62 5R63 6BRB 6QNV 8FN8 8FNB
GO Terms Enriched among Interactors		Keratin Filament	Basement Membrane Calcium Ion Binding Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Locomotion Response To Activity Integrin Alpha5-beta1 Complex Regulation Of Developmental Process Cell-matrix Adhesion Response To Muscle Activity Extracellular Matrix Binding Cell-cell Adhesion Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Calcium-independent Cell-matrix Adhesion Angiogenesis Cell-substrate Adhesion Regulation Of Cell Migration Regulation Of Multicellular Organismal Development Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Motility Regulation Of Locomotion CD40 Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Virus Receptor Activity Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Fibroblast Proliferation Wound Healing, Spreading Of Epidermal Cells Ruffle Membrane Cell Migration Integrin-mediated Signaling Pathway Protease Binding Negative Regulation Of Anoikis Symbiont Entry Into Host Cell Extracellular Space Regulation Of Angiogenesis Regulation Of Vasculature Development Nuclear Matrix Cell Surface Developmental Process Cell Motility Regulation Of Wound Healing Regulation Of Cell Differentiation Regulation Of Anoikis Integrin Complex Regulation Of Neurogenesis Positive Regulation Of Vacuole Organization