KLK3 and SEMG1

Number of citations of the paper that reports this interaction (PMID 11027412)
27

Data Source:
HPRD (in vitro)

		KLK3	SEMG1
Gene Name		kallikrein-related peptidase 3	semenogelin I
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Secretory Granule Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Structural Molecule Activity Protein Binding
	Biological Process	Proteolysis Negative Regulation Of Angiogenesis Cellular Protein Metabolic Process	Insemination
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Amyloids
Drugs
Diseases
GWAS		PCA3 expression level ( 23555189) Prostate cancer ( 18264097) Prostate-specific antigen levels ( 21160077 23269536)
Protein-Protein Interactions		14 interactors: A2M ALB EPOR FN1 IGFBP3 PLG PTHLH PZP SEMG1 SEMG2 SERPINA1 SERPINA3 SERPINA5 SLPI	6 interactors: KLK2 KLK3 PRKCA SEMG2 TGM1 UBQLN4
Entrez ID		354	6406
HPRD ID		01461	01641
Ensembl ID		ENSG00000142515	ENSG00000124233
Uniprot IDs		P07288 Q546G3	P04279
PDB IDs		1PFA 2PSA 2ZCH 2ZCK 2ZCL 3QUM
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Platelet Activation Blood Coagulation Hemostasis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Wound Healing Exocytosis Response To Wounding Acute-phase Response Negative Regulation Of Catalytic Activity Reproductive Process Regulation Of Cellular Protein Metabolic Process Secretion By Cell Regulation Of Protein Metabolic Process Acute Inflammatory Response Regulation Of Catalytic Activity Extracellular Matrix Disassembly Secretion Cell Activation Negative Regulation Of Cellular Metabolic Process Tissue Homeostasis Multicellular Organismal Homeostasis Female Pregnancy Response To Methanol Nipple Sheath Formation Mammary Gland Bud Elongation Vesicle-mediated Transport Endoderm Development Extracellular Matrix Organization Extracellular Structure Organization Maintenance Of Mitochondrion Location Erythropoietin-mediated Signaling Pathway Response To Triglyceride Negative Regulation Of Complement Activation, Lectin Pathway Response To Stress Inflammatory Response Response To Platinum Ion Mononuclear Cell Migration Hemolysis By Symbiont Of Host Erythrocytes	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Positive Regulation Of Inflammatory Response Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Blood Coagulation Regulation Of Wound Healing Factor XII Activation Cell Envelope Organization Histone H3-T6 Phosphorylation Positive Regulation Of Fibrinolysis Regulation Of Angiogenesis Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Inflammatory Response Plasminogen Activation Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Plasma Kallikrein-kinin Cascade Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Blood Coagulation Hemostasis Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Processing Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Acute Inflammatory Response Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Fibrinolysis Regulation Of Cardiac Muscle Hypertrophy Rhodopsin Mediated Signaling Pathway Regulation Of Platelet Activation Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction Inactivation Of MAPK Activity Regulation Of Body Fluid Levels Wound Healing Mitotic Nuclear Envelope Disassembly
Tagcloud ?		ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically	acids amino assisted changed computer cysteine ejaculation epididymal eppin fragment fragments glycine hydrolyzed lactotransferrin live motility originally progressive protease psa recombinant reversing semenogelin seminal sperm spermatozoa spinlw1 washed
Tagcloud (Difference) ?		ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically	acids amino assisted changed computer cysteine ejaculation epididymal eppin fragment fragments glycine hydrolyzed lactotransferrin live motility originally progressive protease psa recombinant reversing semenogelin seminal sperm spermatozoa spinlw1 washed
Tagcloud (Intersection) ?