KLK3 and PTHLH

Number of citations of the paper that reports this interaction (PMID 8683730)
21

Data Source:
HPRD (in vitro)

		KLK3	PTHLH
Gene Name		kallikrein-related peptidase 3	parathyroid hormone-like hormone
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Golgi Apparatus
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Hormone Activity Peptide Hormone Receptor Binding
	Biological Process	Proteolysis Negative Regulation Of Angiogenesis Cellular Protein Metabolic Process	Skeletal System Development Endochondral Ossification Osteoblast Development Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Endoderm Development Female Pregnancy Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Epidermis Development Regulation Of Gene Expression Protein Processing Positive Regulation Of CAMP Biosynthetic Process Epithelial Cell Differentiation Negative Regulation Of Chondrocyte Differentiation Surfactant Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity CAMP Metabolic Process Lung Alveolus Development Mammary Gland Bud Elongation Nipple Sheath Formation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		PCA3 expression level ( 23555189) Prostate cancer ( 18264097) Prostate-specific antigen levels ( 21160077 23269536)	Breast cancer ( 23535729 23535733) Breast size ( 22747683)
Protein-Protein Interactions		14 interactors: A2M ALB EPOR FN1 IGFBP3 PLG PTHLH PZP SEMG1 SEMG2 SERPINA1 SERPINA3 SERPINA5 SLPI	6 interactors: ARRB1 CDK2 IL6 KLK3 KPNB1 PTH1R
Entrez ID		354	5744
HPRD ID		01461	01348
Ensembl ID		ENSG00000142515	ENSG00000087494
Uniprot IDs		P07288 Q546G3	P12272 Q53XY9
PDB IDs		1PFA 2PSA 2ZCH 2ZCK 2ZCL 3QUM	1BZG 1ET3 1M5N 3FFD 3H3G
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Platelet Activation Blood Coagulation Hemostasis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Wound Healing Exocytosis Response To Wounding Acute-phase Response Negative Regulation Of Catalytic Activity Reproductive Process Regulation Of Cellular Protein Metabolic Process Secretion By Cell Regulation Of Protein Metabolic Process Acute Inflammatory Response Regulation Of Catalytic Activity Extracellular Matrix Disassembly Secretion Cell Activation Negative Regulation Of Cellular Metabolic Process Tissue Homeostasis Multicellular Organismal Homeostasis Female Pregnancy Response To Methanol Nipple Sheath Formation Mammary Gland Bud Elongation Vesicle-mediated Transport Endoderm Development Extracellular Matrix Organization Extracellular Structure Organization Maintenance Of Mitochondrion Location Erythropoietin-mediated Signaling Pathway Response To Triglyceride Negative Regulation Of Complement Activation, Lectin Pathway Response To Stress Inflammatory Response Response To Platinum Ion Mononuclear Cell Migration Hemolysis By Symbiont Of Host Erythrocytes	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Positive Regulation Of Acute Inflammatory Response Bone Remodeling Regulation Of Protein Processing Positive Regulation Of DNA Replication Regulation Of Acute Inflammatory Response Acute Inflammatory Response Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Inflammatory Response Glucagon Secretion Cellular Response To Reactive Oxygen Species Positive Regulation Of Cellular Biosynthetic Process Regulation Of Interleukin-6 Production Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Metabolic Process Tissue Remodeling Regulation Of DNA Replication Positive Regulation Of ERK1 And ERK2 Cascade Factor XII Activation Hepatic Immune Response Positive Regulation Of DNA Metabolic Process Regulation Of Carbohydrate Metabolic Process T-helper 17 Cell Lineage Commitment Negative Regulation Of Chemokine Biosynthetic Process Neutrophil Apoptotic Process Positive Regulation Of Cell Proliferation Cellular Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of DNA-dependent DNA Replication Initiation Positive Regulation Of STAT Protein Import Into Nucleus Positive Regulation Of Fibrinolysis Platelet Activation Positive Regulation Of Protein Secretion Response To Reactive Oxygen Species Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination Negative Regulation Of Cytokine Production Regulation Of Cysteine-type Endopeptidase Activity T-helper 17 Cell Differentiation Apoptotic Process Regulation Of Angiogenesis Programmed Cell Death
Tagcloud ?		ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically	2p11 3p13 assigned atrophy cd4 chromosomal chromosome del deletion dentatorubral drpla f8vwf genotypes hormone localization loci mapped mapping p11 p12 p13 p55 pallidoluysian parathyroid parents precise segregation von willebrand
Tagcloud (Difference) ?		ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically	2p11 3p13 assigned atrophy cd4 chromosomal chromosome del deletion dentatorubral drpla f8vwf genotypes hormone localization loci mapped mapping p11 p12 p13 p55 pallidoluysian parathyroid parents precise segregation von willebrand
Tagcloud (Intersection) ?