KLK3 and PTHLH

Number of citations of the paper that reports this interaction (PubMedID 8683730)
0

Data Source:
HPRD (in vitro)

		KLK3	PTHLH
Description		kallikrein related peptidase 3	parathyroid hormone like hormone
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Secretory Granule Protein-containing Complex Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides	Hormone Activity Protein Binding Peptide Hormone Receptor Binding
	Biological Process	Positive Regulation Of Antibacterial Peptide Production Regulation Of Systemic Arterial Blood Pressure Proteolysis Negative Regulation Of Angiogenesis Zymogen Activation	Skeletal System Development Osteoblast Development Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epidermis Development Regulation Of Gene Expression Bone Mineralization Regulation Of Chondrocyte Differentiation Negative Regulation Of Chondrocyte Differentiation CAMP Metabolic Process Negative Regulation Of Chondrocyte Development Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs		Mifepristone Metribolone Cyproterone acetate Gallium Ga-68 gozetotide Lutetium Lu-177 vipivotide tetraxetan
Diseases
GWAS		Celiac disease ( 23936387) Elevated serum prostate-specific antigen levels in healthy men ( 28471803) PCA3 expression level ( 23555189) Prostate cancer ( 18264097 24753544 26034056 31562322 34012061) Prostate cancer (early onset) ( 24740154) Prostate cancer aggressiveness ( 25939597) Prostate-specific antigen levels ( 23269536 24919509 25434496 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Serum prostate-specific antigen levels ( 21160077)	Asthma and hay fever ( 24388013) Blood protein levels ( 30072576) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Breast cancer ( 23535729 31757997 27117709 23535733) Breast cancer (estrogen-receptor negative) ( 27117709) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast size ( 27182965 22747683) Glaucoma (primary open-angle) ( 33627673) Height ( 31562340) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082) Male-pattern baldness ( 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis (hip) ( 30664745) Serum metabolite concentrations in chronic kidney disease ( 33838163)
Interacting Genes		14 interacting genes: A2M ALB EPOR FN1 IGFBP3 PLG PTHLH PZP SEMG1 SEMG2 SERPINA1 SERPINA3 SERPINA5 SLPI	7 interacting genes: ARRB1 CDK2 IL6 KLK3 KPNB1 MTDH PTH1R
Entrez ID		354	5744
HPRD ID		01461	01348
Ensembl ID		ENSG00000142515	ENSG00000087494
Uniprot IDs		P07288 Q546G3	P12272 Q53XY9
PDB IDs		2ZCH 2ZCK 2ZCL 3QUM 9F1I	1BZG 1M5N 3FFD 3H3G 7UZO 7UZP 7VVJ 8D51 8D52 8FLR 8HAF
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Protease Binding Platelet Alpha Granule Lumen Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Extracellular Matrix Blood Microparticle Extracellular Exosome Coagulation Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Acute-phase Response Endopeptidase Inhibitor Activity Acute Inflammatory Response Antibacterial Humoral Response Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Reproductive Process Endoplasmic Reticulum Lumen Regulation Of Flagellated Sperm Motility Regulation Of Endopeptidase Activity Sperm Capacitation Antimicrobial Humoral Response Regulation Of Cilium Movement Defense Response Biological Process Involved In Interaction With Symbiont Developmental Process Involved In Reproduction Growth Factor Binding Erythropoietin Receptor Activity Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Regulation Of Microtubule-based Movement Regulation Of Cell Motility Humoral Immune Response Regulation Of Locomotion Negative Regulation Of Reproductive Process Negative Regulation Of Complement Activation, Lectin Pathway Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Seminal Clot Liquefaction	Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Vasculature Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Angiogenesis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Glucagon Secretion Neutrophil Apoptotic Process Regulation Of Metabolic Process Angiotensin Receptor Binding Regulation Of Interleukin-8 Production Positive Regulation Of Intracellular Signal Transduction Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Interleukin-21 Production Hepatic Immune Response Parathyroid Hormone Receptor Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Negative Regulation Of Primary MiRNA Processing Interleukin-6 Receptor Complex Positive Regulation Of Antibacterial Peptide Production Regulation Of Interleukin-6 Production X Chromosome Mitotic Chromosome Movement Towards Spindle Pole Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus Positive Regulation Of Small Molecule Metabolic Process Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Macromolecule Biosynthetic Process Regulation Of Antibacterial Peptide Production Positive Regulation Of Antimicrobial Peptide Production Regulation Of Gene Expression Positive Regulation Of Antimicrobial Humoral Response Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway
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