CHP2 and SLC9A3

Number of citations of the paper that reports this interaction (PMID 8901634)
31

Data Source:
HPRD (in vitro, in vivo)

		CHP2	SLC9A3
Gene Name		calcineurin-like EF-hand protein 2	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Plasma Membrane Brush Border Cell Surface Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding	Protein Binding Sodium:proton Antiporter Activity PDZ Domain Binding
	Biological Process	Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphatase Activity Protein Transport Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Calcium Ion	Ion Transport Regulation Of PH Sodium Ion Transmembrane Transport Transmembrane Transport Hydrogen Ion Transmembrane Transport
Pathways			Sodium/Proton exchangers Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport
Drugs
Diseases
GWAS			Ulcerative colitis ( 23128233)
Protein-Protein Interactions		5 interactors: SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5	8 interactors: CHP1 CHP2 LRP2 MAST2 PDZK1 SHANK2 SLC9A3R1 SLC9A3R2
Entrez ID		63928	6550
HPRD ID		14259	01660
Ensembl ID		ENSG00000166869	ENSG00000066230
Uniprot IDs		A8K2I8 O43745	P48764
PDB IDs		2BEC
Enriched GO Terms of Interacting Partners?		Regulation Of PH Hydrogen Ion Transmembrane Transport Sodium Ion Transmembrane Transport Proton Transport Sodium Ion Transport Ion Homeostasis Monovalent Inorganic Cation Transport Metal Ion Transport Chemical Homeostasis Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Homeostatic Process Transmembrane Transport Ion Transport Sodium Ion Import Across Plasma Membrane Sodium Ion Import Cardiac Muscle Cell Contraction Regulation Of The Force Of Heart Contraction By Cardiac Conduction Transport Positive Regulation Of Calcium:sodium Antiporter Activity Positive Regulation Of The Force Of Heart Contraction Positive Regulation Of Calcineurin-NFAT Signaling Cascade Sodium Ion Export Positive Regulation Of NFAT Protein Import Into Nucleus Cellular Response To Acidic PH Positive Regulation Of Action Potential Response To Muscle Stretch Regulation Of Cardiac Muscle Cell Membrane Potential Gastric Acid Secretion Maintenance Of Cell Polarity Cellular Response To Electrical Stimulus Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Sodium Ion Homeostasis Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Hyaluronan Catabolic Process Cellular Response To PH Positive Regulation Of Sodium Ion Transmembrane Transport Cellular Response To Epinephrine Stimulus Response To Acidic PH Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Mitochondrial Membrane Permeability Response To Epinephrine Cellular Response To Antibiotic Cellular Response To Toxic Substance Sodium Ion Homeostasis Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Sensory Perception Of Pain Cellular Response To Catecholamine Stimulus	Regulation Of Sodium:proton Antiporter Activity Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Proton Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Intracellular Protein Transport Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intracellular Transport Regulation Of Sodium Ion Transmembrane Transport Regulation Of Intracellular Protein Transport Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Transport Regulation Of Sodium Ion Transport Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Intracellular Transport Renal Phosphate Ion Absorption Negative Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Phosphatase Activity Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Regulation Of Dephosphorylation Monocarboxylic Acid Transport Regulation Of Protein Transport Regulation Of Ion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Monovalent Inorganic Cation Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Protein Glycosylation Regulation Of Protein Import Into Nucleus Positive Regulation Of Transport Regulation Of Signaling Renal Sodium Ion Transport Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Ion Transport Cellular Component Assembly Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Sodium Ion Transmembrane Transport Protein Localization
Tagcloud ?		asf1 assemble associate boundary chaperone clr6 concert deacetylases deacetylation enforce fission hdac hdacs heterochromatic heterochromatin hira hp1 nucleosome occupancy recruiting repressive shrec silence silenced snf2 spreads swi6 tfiiic uncover	1p11 1q42 allows approximate assigned candidate centromere chr chromosomes comparative cytogenetic deduce encoding exchanger expand integrates linkage localizations localized loci map mapping na orient position rat regionally respect unlikely
Tagcloud (Difference) ?		asf1 assemble associate boundary chaperone clr6 concert deacetylases deacetylation enforce fission hdac hdacs heterochromatic heterochromatin hira hp1 nucleosome occupancy recruiting repressive shrec silence silenced snf2 spreads swi6 tfiiic uncover	1p11 1q42 allows approximate assigned candidate centromere chr chromosomes comparative cytogenetic deduce encoding exchanger expand integrates linkage localizations localized loci map mapping na orient position rat regionally respect unlikely
Tagcloud (Intersection) ?