TNR and SIGLEC1

Number of citations of the paper that reports this interaction (PubMedID 10406848)
0

Data Source:
HPRD (in vitro)

		TNR	SIGLEC1
Description		tenascin R	sialic acid binding Ig like lectin 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Extracellular Matrix Membrane Raft Perineuronal Net Tenascin Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Extracellular Region Early Endosome Late Endosome Plasma Membrane Membrane
	Molecular Function		Carbohydrate Binding Virion Binding
	Biological Process	Cell Adhesion Neuron Cell-cell Adhesion Nervous System Development Axon Guidance Associative Learning Negative Regulation Of Neuron Projection Development Telencephalon Cell Migration Negative Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Negative Regulation Of Axon Extension Synaptic Transmission, Glutamatergic Locomotory Exploration Behavior Regulation Of Cell Differentiation Axon Extension Axon Extension Involved In Regeneration Negative Regulation Of Axon Extension Involved In Regeneration Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Transmission Of Nerve Impulse Long-term Synaptic Potentiation Neuroblast Migration	Endocytosis Inflammatory Response Cell Adhesion Cell-matrix Adhesion Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Clathrin-dependent Endocytosis Of Virus By Host Cell Cell-cell Adhesion
Pathways		ECM proteoglycans	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs			Beta-D-Glucose N-acetyl-alpha-neuraminic acid
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Attention deficit hyperactivity disorder ( 30563984) Body mass index ( 26426971) Corneal astigmatism ( 29422769) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Liver fibrosis in non-alcoholic fatty liver disease ( 31311600) Sleep (1/2-day periodicity) ( 33075057) Telomere length ( 30185882) Testosterone levels x fluid intelligence interaction ( 33407712) Tonometry ( 17903302)	IgM levels ( 28628107) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Night sleep phenotypes ( 27126917) Reticulocyte fraction of red cells ( 32888494) Visceral fat ( 30942860)
Interacting Genes		16 interacting genes: ACAN BCAN CCDC146 CNTN1 LGALS14 MAGEB4 NCAN NCK2 NFASC NTAQ1 POLR3C PSMA1 PTPRZ1 SIGLEC1 TRIM54 VCAN	3 interacting genes: MUC1 SPN TNR
Entrez ID		7143	6614
HPRD ID		03589	02854
Ensembl ID		ENSG00000116147	ENSG00000088827
Uniprot IDs		A1L306 Q92752	Q9BZZ2
PDB IDs		8FN9 8FNA
Enriched GO Terms of Interacting Partners?		Perineuronal Net Carbohydrate Binding Hyaluronic Acid Binding Central Nervous System Development Lysosomal Lumen Golgi Lumen Cell Adhesion Synapse Skeletal System Development Extracellular Matrix Structural Constituent Conferring Compression Resistance System Development Cell-cell Adhesion Mediator Activity Extracellular Matrix Clathrin-dependent Endocytosis Of Virus By Host Cell Protein-N-terminal Glutamine Amidohydrolase Activity	Negative Regulation Of Cell Adhesion Regulation Of Cell Adhesion Extracellular Space Negative Regulation Of Type IV Hypersensitivity T-helper 1 Cell Lineage Commitment Negative Regulation Of Cell-cell Adhesion Regulation Of Type IV Hypersensitivity Tenascin Complex Axon Extension Involved In Regeneration Neuroblast Migration Negative Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cellular Response To Stress Negative Regulation Of Transcription By Competitive Promoter Binding Mitotic G1/S Transition Checkpoint Signaling Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Cell Adhesion Mediated By Integrin Cell-cell Adhesion Negative Regulation Of Acute Inflammatory Response Regulation Of Cell-cell Adhesion Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Thymic T Cell Selection Negative T Cell Selection Uropod Locomotory Exploration Behavior Neuron Cell-cell Adhesion Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration Perineuronal Net T-helper Cell Lineage Commitment Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Leukocyte Tethering Or Rolling Thymic T Cell Selection CD4-positive, Alpha-beta T Cell Lineage Commitment Leukocyte Adhesion To Vascular Endothelial Cell Alpha-beta T Cell Lineage Commitment Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cell Surface CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Axon Regeneration Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Protozoan T Cell Lineage Commitment T Cell Selection Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Neuron Projection Regeneration Negative Regulation Of Axon Extension
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