MMP8 and TIMP2

Number of citations of the paper that reports this interaction (PubMedID 10353844)
0

Data Source:
HPRD (in vitro)

		MMP8	TIMP2
Description		matrix metallopeptidase 8	TIMP metallopeptidase inhibitor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Specific Granule Lumen Tertiary Granule Lumen	Extracellular Region Extracellular Space Extracellular Matrix Secretory Granule Lumen Specific Granule Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Tumor Necrosis Factor Binding Metal Ion Binding	Protease Binding Enzyme Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity Metal Ion Binding Molecular Function Inhibitor Activity
	Biological Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Endodermal Cell Differentiation Cellular Response To Lipopolysaccharide Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Microglial Cell Activation	Response To Hormone Response To Cytokine Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metallopeptidase Activity
Pathways		Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Neutrophil degranulation	Activation of Matrix Metalloproteinases Neutrophil degranulation TGFBR3 PTM regulation
Drugs		Marimastat 1-Hydroxyamine-2-Isobutylmalonic Acid 2-Thiomethyl-3-Phenylpropanoic Acid 2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid 5-[4-(2-Hydroxyethyl)-1-piperidinyl]-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione Glycinamide Batimastat N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]ETHYL}-N'-HYDROXY-N-METHYLUREA (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide (1S)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid (1R)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid 3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID 3-AMINO-AZACYCLOTRIDECAN-2-ONE
Diseases
GWAS		Blood protein levels ( 30072576) Epilepsy ( 25087078) Prostate cancer ( 23535732)	Blood protein levels ( 30072576) Dupuytren's disease ( 21732829) Heel bone mineral density ( 30598549) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Periodontitis (CDC/AAP) ( 24024966)
Interacting Genes		7 interacting genes: ACAN BCAN CCL2 FBXO7 TFPI TIMP2 UMOD	6 interacting genes: ITGA3 ITGB1 MMP14 MMP2 MMP8 UBQLN2
Entrez ID		4317	7077
HPRD ID		00385	01784
Ensembl ID		ENSG00000118113	ENSG00000035862
Uniprot IDs		B4E0I2 P22894	A0A140VK57 P16035
PDB IDs		1A85 1A86 1BZS 1I73 1I76 1JAN 1JAO 1JAP 1JAQ 1JH1 1JJ9 1KBC 1MMB 1MNC 1ZP5 1ZS0 1ZVX 2OY2 2OY4 3DNG 3DPE 3DPF 3TT4 4QKZ 5H8X	1BR9 1GXD 2TMP 4ILW
Enriched GO Terms of Interacting Partners?		Golgi Lumen Perineuronal Net Extracellular Space Side Of Membrane Extracellular Region Hyaluronic Acid Binding Cell Adhesion Helper T Cell Extravasation Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Chemokine (C-C Motif) Ligand 2 Signaling Pathway Citric Acid Secretion Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Extracellular Matrix Lysosomal Lumen Granulocyte Migration Negative Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of Metallopeptidase Activity Metanephric Thick Ascending Limb Development Protein Transport Into Plasma Membrane Raft Micturition Peptidase Inhibitor Activity Negative Regulation Of Lymphocyte Chemotaxis Myeloid Leukocyte Migration Regulation Of Metallopeptidase Activity Juxtaglomerular Apparatus Development Renal Urate Salt Excretion Lewy Body Core Central Nervous System Development CCR2 Chemokine Receptor Binding Response To Water Deprivation Metanephric Ascending Thin Limb Development Protein Transport Into Membrane Raft Metanephric Distal Convoluted Tubule Development Negative Regulation Of Mitotic Cell Cycle Phase Transition T Cell Extravasation Negative Regulation Of Neuron Apoptotic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Localization To Plasma Membrane Raft Tricarboxylic Acid Transport Loop Of Henle Development Citrate Transport Carbohydrate Binding Regulation Of Cell Cycle G1/S Phase Transition Skeletal System Development Astrocyte Cell Migration Negative Regulation Of Membrane Protein Ectodomain Proteolysis	Fibronectin Binding Integrin Alpha3-beta1 Complex Endodermal Cell Differentiation Collagen Catabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Endopeptidase Activity Metalloendopeptidase Activity Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Vasoconstriction Metallopeptidase Activity Mesodermal Cell Differentiation Integrin Binding Serine-type Endopeptidase Activity Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Cell Migration Laminin Binding Positive Regulation Of Cell Motility Regulation Of Protein Localization To Membrane Positive Regulation Of Locomotion Negative Regulation Of Rho Protein Signal Transduction Regulation Of Signal Transduction Integrin Complex Regulation Of Cell Communication Regulation Of Signaling Cell Migration Angiogenesis Ovarian Follicle Development Regulation Of Cell Migration Regulation Of Cell Motility Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Locomotion Synaptic Membrane Cell Motility Regulation Of Vasoconstriction Response To Estrogen Positive Regulation Of Protein Localization To Plasma Membrane Cell Differentiation Extracellular Matrix Positive Regulation Of Protein Localization To Cell Periphery Focal Adhesion Neuromuscular Junction Myoblast Fate Specification Response To Activity Integrin Alpha7-beta1 Complex Peptidase Activity Proteolysis Cellular Response To Genistein
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