MMP8 and TIMP2

Number of citations of the paper that reports this interaction (PMID 10353844)
1

Data Source:
HPRD (in vitro)

		MMP8	TIMP2
Gene Name		matrix metallopeptidase 8 (neutrophil collagenase)	TIMP metallopeptidase inhibitor 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Cell Surface Growth Cone Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Zinc Ion Binding	Protease Binding Integrin Binding Protein Binding Enzyme Activator Activity Metalloendopeptidase Inhibitor Activity Metal Ion Binding
	Biological Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation	Central Nervous System Development Aging Negative Regulation Of Cell Proliferation Response To Hormone Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Regulation Of Rap Protein Signal Transduction Response To Cytokine Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Organic Substance
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs		Marimastat 1-Hydroxyamine-2-Isobutylmalonic Acid 2-Thiomethyl-3-Phenylpropanoic Acid 2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid 2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperidin-1-Yl]-5-Phenyl-1h-Pyrimidine-4,6-Dione Glycinamid Batimastat N-{2-[(4\'-CYANO-1,1\'-BIPHENYL-4-YL)OXY]ETHYL}-N\'-HYDROXY-N-METHYLUREA (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide (1S)-1-{[(4\'-METHOXY-1,1\'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID (1R)-1-{[(4\'-METHOXY-1,1\'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID 3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID 3-AMINO-AZACYCLOTRIDECAN-2-ONE
Diseases
GWAS		Prostate cancer ( 23535732)	Dupuytren's disease ( 21732829) Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: ACAN BCAN CCL2 TFPI TIMP2 UBC UMOD	5 interactors: ITGA3 ITGB1 MMP14 MMP2 MMP8
Entrez ID		4317	7077
HPRD ID		00385	01784
Ensembl ID		ENSG00000118113	ENSG00000035862
Uniprot IDs		P22894	P16035
PDB IDs		1A85 1A86 1BZS 1I73 1I76 1JAN 1JAO 1JAP 1JAQ 1JH1 1JJ9 1KBC 1MMB 1MNC 1ZP5 1ZS0 1ZVX 2OY2 2OY4 3DNG 3DPE 3DPF 3TT4	1BR9 1GXD 2TMP
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Pathogenesis Neutrophil Migration Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Response To Vitamin B3 Helper T Cell Extravasation Negative Regulation Of Natural Killer Cell Chemotaxis Cellular Response To High Density Lipoprotein Particle Stimulus Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Metanephric Thick Ascending Limb Development Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Lymphocyte Chemotaxis Regulation Of Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Response To Cytokine Response To High Density Lipoprotein Particle Negative Regulation Of Catalytic Activity Glycosaminoglycan Metabolic Process Metanephric Ascending Thin Limb Development Negative Regulation Of Lymphocyte Migration Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Viral Life Cycle Regulation Of Cellular Protein Metabolic Process Response To Transforming Growth Factor Beta Response To Fibroblast Growth Factor Blood Coagulation, Extrinsic Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Extravasation Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Mitotic Cell Cycle Leukocyte Migration MAPK Cascade Metanephric Distal Convoluted Tubule Development Metanephric Loop Of Henle Development Regulation Of Protein Metabolic Process Central Nervous System Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Macrophage Chemotaxis Astrocyte Cell Migration Negative Regulation Of Leukocyte Chemotaxis Positive Regulation Of Apoptotic Cell Clearance	Formation Of Primary Germ Layer Gastrulation Extracellular Matrix Organization Extracellular Structure Organization Embryonic Morphogenesis Endodermal Cell Differentiation Endoderm Formation Collagen Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Embryo Development Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Tissue Development Negative Regulation Of Rho Protein Signal Transduction Regulation Of Cell-substrate Adhesion Cardiovascular System Development Female Pregnancy Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Anatomical Structure Morphogenesis Mesodermal Cell Differentiation Response To Gonadotropin Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Locomotion Single Organism Reproductive Process Locomotion Reproductive Process Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Blood Vessel Morphogenesis Cell Differentiation Movement Of Cell Or Subcellular Component Blood Vessel Development Maternal Process Involved In Female Pregnancy Vasculature Development Neurogenesis Mesoderm Formation Regulation Of Cell Migration Mesoderm Morphogenesis Regulation Of Cell Adhesion Regulation Of Cell Motility Tissue Morphogenesis
Tagcloud ?		appreciated broader cascades classically cleavages cleaving conclusive curated dimension elastase inactivating operational perplexing pervasively polymorphonuclear posttranslational protease proteases proteome reachability representation scattered serpina1 spans subnetworks systematically unraveling viewed web	achn acquired analyze bo5 bone determinants elucidate elucidated enhancer ex explore ezh2 homolog immunohistochemical metalloproteinase metastasis metastasized methylated methylation mmp2 newly parental rcc specimens subline tissues underlying upregulation zeste
Tagcloud (Difference) ?		appreciated broader cascades classically cleavages cleaving conclusive curated dimension elastase inactivating operational perplexing pervasively polymorphonuclear posttranslational protease proteases proteome reachability representation scattered serpina1 spans subnetworks systematically unraveling viewed web	achn acquired analyze bo5 bone determinants elucidate elucidated enhancer ex explore ezh2 homolog immunohistochemical metalloproteinase metastasis metastasized methylated methylation mmp2 newly parental rcc specimens subline tissues underlying upregulation zeste
Tagcloud (Intersection) ?