CCL26 and CCR3

Number of citations of the paper that reports this interaction (PubMedID 10488147)
0

Data Source:
HPRD (in vivo)

		CCL26	CCR3
Description		C-C motif chemokine ligand 26	C-C motif chemokine receptor 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding CX3C Chemokine Receptor Binding Receptor Ligand Activity CCR Chemokine Receptor Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling T Cell Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Eosinophil Chemotaxis Positive Regulation Of Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Positive Regulation Of Angiogenesis Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Carotid plaque burden ( 28282560) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)	Arthritis (juvenile idiopathic) ( 33106285) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Behcet's disease ( 33393726 23291587) Bone mineral density (Ward's triangle area) ( 27397699) Celiac disease ( 25920553 20190752 22057235 24999842 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte chemoattractant protein-1 levels ( 23017229) Monocyte count ( 27863252 29403010) Narcolepsy with cataplexy ( 25986216) Obesity-related traits ( 23251661) Pancreatic beta-cell glucose sensitivity ( 32944759) Ulcerative colitis ( 26192919 28067908) White blood cell count (basophil) ( 27863252)
Interacting Genes		24 interacting genes: APP C3orf52 CCL11 CCL13 CCL17 CCL2 CCL21 CCL28 CCL5 CCL8 CCR1 CCR3 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL9 PAX6 PF4 PF4V1 PPBP XCL1 XCL2	19 interacting genes: CCL11 CCL13 CCL14 CCL15 CCL2 CCL24 CCL26 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CXCL10 CXCL11 CXCL9 FGR HCK
Entrez ID		10344	1232
HPRD ID		05262	03167
Ensembl ID		ENSG00000006606	ENSG00000183625
Uniprot IDs		Q9Y258	P51677 Q8TDP4 Q8TDP5
PDB IDs		1G2S 1G2T	7X9Y
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Antimicrobial Humoral Response Leukocyte Chemotaxis Humoral Immune Response Cytokine Activity Chemokine-mediated Signaling Pathway Leukocyte Migration Myeloid Leukocyte Migration Cell Migration Granulocyte Chemotaxis Cell Motility Killing Of Cells Of Another Organism Granulocyte Migration Inflammatory Response Defense Response To Symbiont Cell Killing Defense Response To Other Organism Immune Response Defense Response Immune System Process Cytokine-mediated Signaling Pathway Response To Other Organism Extracellular Space CXCR Chemokine Receptor Binding CCR Chemokine Receptor Binding Response To External Biotic Stimulus Mononuclear Cell Migration G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Leukocyte Migration Extracellular Region Regulation Of Leukocyte Migration Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Response To Stress Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Eosinophil Chemotaxis Regulation Of Cell Migration Positive Regulation Of Locomotion Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Eosinophil Migration Regulation Of Cell Motility Positive Regulation Of Monocyte Chemotaxis Regulation Of Locomotion Positive Regulation Of Calcium Ion Transport	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway CCR Chemokine Receptor Binding Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Humoral Immune Response Chemotaxis Granulocyte Chemotaxis Locomotion Defense Response To Symbiont Inflammatory Response Defense Response To Other Organism Granulocyte Migration Eosinophil Chemotaxis Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Eosinophil Migration Leukocyte Migration Myeloid Leukocyte Migration Response To Other Organism Immune Response Cell Migration Response To External Biotic Stimulus Defense Response Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Locomotion Immune System Process Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Extracellular Space Cell Surface Receptor Signaling Pathway Extracellular Region Response To Stress Regulation Of Lymphocyte Chemotaxis Cell-cell Signaling Signaling Cell Communication Regulation Of Leukocyte Migration Regulation Of Cell Shape Positive Regulation Of Leukocyte Migration Signal Transduction Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Calcium Ion Transport Intracellular Calcium Ion Homeostasis
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