CCL17 and CCL21

Number of citations: 0 (PubMedID 28381538)
Data Source: BioGRID (pull down)

		CCL17	CCL21
Name		C-C motif chemokine ligand 17	C-C motif chemokine ligand 21
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Chemokine Activity	Cytokine Activity Protein Binding Chemokine Activity CCR7 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Killing Of Cells Of Another Organism Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Establishment Of T Cell Polarity Immunological Synapse Formation Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of T Cell Chemotaxis Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Ruffle Organization Killing Of Cells Of Another Organism Positive Regulation Of Cell Adhesion Mediated By Integrin Mesangial Cell-matrix Adhesion Chemokine (C-C Motif) Ligand 21 Signaling Pathway CCL21-activated CCR7 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade Eosinophil Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Neutrophil Chemotaxis Dendritic Cell Dendrite Assembly Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Negative Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Chemokine Positive Regulation Of Cell Motility Positive Regulation Of T Cell Migration Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Chemokine receptors bind chemokines	Chemokine receptors bind chemokines G alpha (i) signalling events
GWAS		Blood protein levels ( 30072576 ) Thymus and reactivation regulated chemokine levels ( 33227023 )	Autoimmune traits (pleiotropy) ( 30572963 ) Blood protein levels ( 30072576 ) Celiac disease ( 30572963 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Rheumatoid arthritis ( 18794853 23143596 24390342 30423114 30572963 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 )
Novel Interactors		None recorded	5 novel interactors: CCL27 DCTN3 GALT IL11RA RNF38
Interacting Genes		9 interacting genes: ACKR1 CCL21 CCL25 CCL26 CCL28 CCL5 CCR4 CCR8 VCAM1	32 interacting genes: ACKR2 ACKR4 C3orf52 CCL13 CCL17 CCL23 CCL24 CCL26 CCL28 CCL5 CCR7 CTSD CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL17 CXCL2 CXCL9 GOT2 IGFBP7 LRRK1 OTP PF4 PF4V1 PPBP TMEM107 UBQLN4 VCAN XCL1 XCL2
Entrez ID		6361	6366
HPRD ID		03309	04113
Ensembl ID		ENSG00000102970	ENSG00000137077
Uniprot IDs		Q92583	O00585
PDB IDs		1NR2 1NR4 5WK3 7S4N 7SCV 8FJ2 8SKK	2L4N 5EKI
GO Terms Enriched among Interactors		Chemokine-mediated Signaling Pathway Cell Chemotaxis Chemotaxis Locomotion Inflammatory Response Chemokine Receptor Binding Chemokine Activity Cytokine-mediated Signaling Pathway Granulocyte Chemotaxis Eosinophil Chemotaxis Eosinophil Migration Negative Regulation Of Leukocyte Tethering Or Rolling Cell Migration Granulocyte Migration CCR Chemokine Receptor Binding Cell Motility Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Myeloid Leukocyte Migration Leukocyte Chemotaxis Negative Regulation Of Cellular Extravasation Antimicrobial Humoral Response Defense Response G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Cytokine Activity Regulation Of Leukocyte Tethering Or Rolling Leukocyte Migration Humoral Immune Response Immune System Process C-C Chemokine Binding Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Cellular Response To Cytokine Stimulus Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Negative Regulation Of Leukocyte Migration Regulation Of Leukocyte Migration Positive Regulation Of Cell-matrix Adhesion Response To Cytokine Response To Peptide Cell Surface Receptor Signaling Pathway Response To Stress Response To External Biotic Stimulus Defense Response To Symbiont Defense Response To Other Organism Mononuclear Cell Migration Positive Regulation Of T Cell Chemotaxis Regulation Of Cell Adhesion	Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Antimicrobial Humoral Response Cytokine Activity Leukocyte Chemotaxis Humoral Immune Response Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Leukocyte Migration Cell Migration Granulocyte Chemotaxis CXCR Chemokine Receptor Binding Cell Motility Killing Of Cells Of Another Organism Granulocyte Migration Inflammatory Response Cell Killing Cytokine-mediated Signaling Pathway Defense Response To Symbiont Immune Response Defense Response To Other Organism Extracellular Space Mononuclear Cell Migration Immune System Process Defense Response Neutrophil Chemotaxis Extracellular Region Response To Other Organism Response To External Biotic Stimulus Neutrophil Migration CXCR3 Chemokine Receptor Binding CCR Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Lymphocyte Chemotaxis Chemokine Receptor Binding Lymphocyte Migration Cell-cell Signaling Signaling Cell Communication Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Regulation Of Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Cell Motility