ADCYAP1 and ADCYAP1R1

Number of citations of the paper that reports this interaction (PubMedID 10583729)
0

Data Source:
HPRD (in vitro, in vivo)

		ADCYAP1	ADCYAP1R1
Description		adenylate cyclase activating polypeptide 1	ADCYAP receptor type I
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Neuron Projection Perikaryon	Endosome Plasma Membrane Caveola Bicellular Tight Junction Cell Surface Membrane Receptor Complex
	Molecular Function	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Peptide Hormone Receptor Binding	Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity Protein Binding Adenylate Cyclase Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Small GTPase Binding Signaling Receptor Activity Neuropeptide Binding
	Biological Process	Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Nervous System Development Female Pregnancy Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Insulin Secretion Neuron Projection Development Regulation Of Protein Localization Positive Regulation Of GTPase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Growth Hormone Secretion Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of CAMP/PKA Signal Transduction	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Response To Xenobiotic Stimulus Positive Regulation Of Calcium Ion Transport Into Cytosol Cell Differentiation Response To Estradiol Multicellular Organismal Response To Stress Response To Ethanol Development Of Primary Female Sexual Characteristics Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Inositol Phosphate Biosynthetic Process CAMP/PKA Signal Transduction Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Response To Reactive Oxygen Species
Pathways		NGF-independant TRKA activation G alpha (s) signalling events Glucagon-type ligand receptors	NGF-independant TRKA activation G alpha (s) signalling events Glucagon-type ligand receptors
Drugs		2,6-Diamino-Hexanoic Acid Amide
Diseases
GWAS		Body size at age 10 ( 32376654) Chronotype ( 30696823) Midgestational cytokine/chemokine levels (fetal genetic effect) ( 30134952) Obesity-related traits ( 23251661) Pancreas volume ( 34128465) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)	Cluster headache ( 27957625) Major depressive disorder ( 21621269) Non-word reading ( 30741946) Vitamin B levels in ischemic stroke ( 25147783)
Interacting Genes		9 interacting genes: ADCYAP1R1 CASP2 CFTR CPAMD8 MME SCTR SHH VIPR1 VIPR2	3 interacting genes: ADCYAP1 CALM1 ZDHHC15
Entrez ID		116	117
HPRD ID		02369	00045
Ensembl ID		ENSG00000141433	ENSG00000078549
Uniprot IDs		B7Z222 P18509	A0A090N8F8 A0A994J7E9 P41586
PDB IDs		1GEA 2D2P 2JOD 6LPB 6M1I 6P9Y 6VN7 7VQX 7WBJ 8E3X 8E3Y	2JOD 3N94 6LPB 6M1H 6M1I 6P9Y 7JQD 8E3X
Enriched GO Terms of Interacting Partners?		Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity Peptide Hormone Binding G Protein-coupled Peptide Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Transmembrane Signaling Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Protein Processing Cell Surface Receptor Signaling Pathway Plasma Membrane Negative Regulation Of Response To Reactive Oxygen Species G Protein-coupled Receptor Signaling Pathway Cell Surface Protein Maturation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Neuropeptide Processing Secretin Receptor Activity Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Left Lung Development Positive Regulation Of Sclerotome Development Right Lung Development Polarity Specification Of Anterior/posterior Axis Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Primary Prostatic Bud Elongation Tracheoesophageal Septum Formation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Odontogenesis Of Dentin-containing Tooth Developmental Process Involved In Reproduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Anion Channel Activity Endopeptidase Activity Oligopeptidase Activity Creatinine Metabolic Process Intein-mediated Protein Splicing Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Peptidase Activity Endopeptidase Complex Odontogenesis Positive Regulation Of Monoatomic Anion Transport Lung Development Substance P Catabolic Process Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development	Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Calcium Channel Activity Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Lipoprotein Transport Regulation Of Intracellular Cholesterol Transport Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Synaptic Vesicle Maturation Protein Targeting To Golgi Apparatus Positive Regulation Of Growth Hormone Secretion Rough Endoplasmic Reticulum Membrane Regulation Of Intracellular Lipid Transport Peptide Hormone Receptor Binding Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Peptidyl-L-cysteine S-palmitoylation Regulation Of Growth Hormone Secretion Regulation Of Transport Activation Of Adenylate Cyclase Activity Titin Binding Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Calcium Channel Inhibitor Activity Oxysterol Binding Positive Regulation Of Dendrite Development Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Adenylate Cyclase Activity Protein Phosphatase Activator Activity Protein Palmitoylation Calyx Of Held Palmitoyltransferase Activity Positive Regulation Of Lyase Activity Protein-cysteine S-palmitoyltransferase Activity Positive Regulation Of Cyclase Activity Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity
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