ADCYAP1

Name	adenylate cyclase activating polypeptide 1
Structure
Interactors	9 interactors: ADCYAP1R1 CASP2 CFTR CPAMD8 MME SCTR SHH VIPR1 VIPR2
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Neuron Projection Perikaryon
	Molecular Function	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Peptide Hormone Receptor Binding
	Biological Process	Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Nervous System Development Female Pregnancy Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Insulin Secretion Neuron Projection Development Regulation Of Protein Localization Positive Regulation Of GTPase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Growth Hormone Secretion Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of CAMP/PKA Signal Transduction
Pathways	NGF-independant TRKA activation G alpha (s) signalling events Glucagon-type ligand receptors
Drugs	2,6-Diamino-Hexanoic Acid Amide
GWAS	Body size at age 10 ( 32376654 ) Chronotype ( 30696823 ) Midgestational cytokine/chemokine levels (fetal genetic effect) ( 30134952 ) Obesity-related traits ( 23251661 ) Pancreas volume ( 34128465 ) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659 )
Entrez ID	116
HPRD ID	02369
Ensembl ID	ENSG00000141433
Uniprot IDs	B7Z222 P18509
PDB IDs	1GEA 2D2P 2JOD 6LPB 6M1I 6P9Y 6VN7 7VQX 7WBJ 8E3X 8E3Y
GO Terms Enriched among Interactors ?	Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity Peptide Hormone Binding G Protein-coupled Peptide Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Transmembrane Signaling Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Protein Processing Cell Surface Receptor Signaling Pathway Plasma Membrane Negative Regulation Of Response To Reactive Oxygen Species G Protein-coupled Receptor Signaling Pathway Cell Surface Protein Maturation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Neuropeptide Processing Secretin Receptor Activity Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Left Lung Development Positive Regulation Of Sclerotome Development Right Lung Development Polarity Specification Of Anterior/posterior Axis Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Primary Prostatic Bud Elongation Tracheoesophageal Septum Formation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Odontogenesis Of Dentin-containing Tooth Developmental Process Involved In Reproduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Anion Channel Activity Endopeptidase Activity Oligopeptidase Activity Creatinine Metabolic Process Intein-mediated Protein Splicing Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Peptidase Activity Endopeptidase Complex Odontogenesis Positive Regulation Of Monoatomic Anion Transport Lung Development Substance P Catabolic Process Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development