ADCYAP1 and VIPR2

Number of citations of the paper that reports this interaction (PubMedID 8146174)
29

Data Source:
HPRD (in vitro, in vivo)

		ADCYAP1	VIPR2
Description		adenylate cyclase activating polypeptide 1	vasoactive intestinal peptide receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Neuron Projection Perikaryon	Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Peptide Hormone Receptor Binding	Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding
	Biological Process	Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Nervous System Development Female Pregnancy Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Insulin Secretion Neuron Projection Development Regulation Of Protein Localization Positive Regulation Of GTPase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Growth Hormone Secretion Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of CAMP/PKA Signal Transduction	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling
Pathways		NGF-independant TRKA activation G alpha (s) signalling events Glucagon-type ligand receptors	G alpha (s) signalling events Glucagon-type ligand receptors
Drugs		2,6-Diamino-Hexanoic Acid Amide
Diseases
GWAS		Body size at age 10 ( 32376654) Chronotype ( 30696823) Midgestational cytokine/chemokine levels (fetal genetic effect) ( 30134952) Obesity-related traits ( 23251661) Pancreas volume ( 34128465) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)	Academic attainment (English) ( 33594131) Corneal astigmatism ( 30306274) Diastolic blood pressure x quantitative lifestyle risk score interaction (1df test) ( 32227373) Diastolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hearing loss in noise exposure ( 33242228) Myopia (pathological) ( 23406873) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Sub-foveal choroidal thickness ( 29844195)
Interacting Genes		9 interacting genes: ADCYAP1R1 CASP2 CFTR CPAMD8 MME SCTR SHH VIPR1 VIPR2	6 interacting genes: ADCYAP1 APP DBNDD2 ERBIN RGS14 VIP
Entrez ID		116	7434
HPRD ID		02369	03576
Ensembl ID		ENSG00000141433	ENSG00000106018
Uniprot IDs		B7Z222 P18509	P41587 X5D7Q6 X5DP12
PDB IDs		1GEA 2D2P 2JOD 6LPB 6M1I 6P9Y 6VN7 7VQX 7WBJ 8E3X 8E3Y	2X57 7VQX 7WBJ
Enriched GO Terms of Interacting Partners?		Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity Peptide Hormone Binding G Protein-coupled Peptide Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Transmembrane Signaling Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Protein Processing Cell Surface Receptor Signaling Pathway Plasma Membrane Negative Regulation Of Response To Reactive Oxygen Species G Protein-coupled Receptor Signaling Pathway Cell Surface Protein Maturation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Neuropeptide Processing Secretin Receptor Activity Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Left Lung Development Positive Regulation Of Sclerotome Development Right Lung Development Polarity Specification Of Anterior/posterior Axis Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Primary Prostatic Bud Elongation Tracheoesophageal Septum Formation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Odontogenesis Of Dentin-containing Tooth Developmental Process Involved In Reproduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Anion Channel Activity Endopeptidase Activity Oligopeptidase Activity Creatinine Metabolic Process Intein-mediated Protein Splicing Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Peptidase Activity Endopeptidase Complex Odontogenesis Positive Regulation Of Monoatomic Anion Transport Lung Development Substance P Catabolic Process Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development	Positive Regulation Of CAMP/PKA Signal Transduction Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Regulation Of CAMP/PKA Signal Transduction Regulation Of Chemokine Production Peptide Hormone Receptor Binding Antifungal Humoral Response Response To Yeast Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Neuropeptide Hormone Activity Regulation Of Protein Kinase Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Kinase Activity Regulation Of Signaling Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Neuron Projection Visual Learning Defense Response To Fungus Response To Fungus Visual Behavior Antibacterial Humoral Response Regulation Of Protein Phosphorylation Signaling Receptor Binding Signal Transduction Peptide Hormone Secretion Positive Regulation Of Chemokine Production Negative Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Pituitary Adenylate Cyclase Activating Polypeptide Activity Peptide Secretion Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Epinephrine Secretion Negative Regulation Of Kinase Activity Zygote Asymmetric Cell Division Negative Regulation Of Macromolecule Metabolic Process Neuron Projection Development Regulation Of Biological Quality Defense Response To Gram-negative Bacterium Hormone Secretion
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