LCP1 and CNN3

Number of citations: 29 (PubMedID 11591653)
Data Source: HPRD (in vivo)

		LCP1	CNN3
Name		lymphocyte cytosolic protein 1	calponin 3
Structure			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Ruffle Phagocytic Cup Podosome Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Cell Junction Filopodium Actin Filament Bundle Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Glial Cell Projection	Cytosol Adherens Junction Focal Adhesion Actin Cytoskeleton
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding GTPase Binding	Actin Binding Calmodulin Binding Actin Filament Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	T Cell Activation Involved In Immune Response Protein Kinase A Signaling Cell Migration Extracellular Matrix Disassembly Cortical Actin Cytoskeleton Organization Animal Organ Regeneration Regulation Of Intracellular Protein Transport Wound Healing, Spreading Of Cells Actin Filament Bundle Assembly Actin Filament Network Formation Actin Crosslink Formation Positive Regulation Of Podosome Assembly	Actin Filament Organization Epithelial Cell Differentiation Actomyosin Structure Organization Cell-cell Adhesion
Pathways		Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	None
GWAS		Blood protein levels ( 30072576 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 ) Lymphocyte count ( 32888494 ) Mean platelet volume ( 32888494 ) Non-alcoholic fatty liver disease histology (other) ( 23213074 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Systemic lupus erythematosus ( 26502338 )	Bipolar disorder ( 31043756 ) Palmitic acid (16:0) levels ( 23362303 ) Stearic acid (18:0) levels ( 23362303 )
Novel Interactors		1 novel interactors: NLGN4X	None recorded
Interacting Genes		7 interacting genes: AIF1 ATXN2 CEBPA CNN3 GCA PDE4B PRKACA	5 interacting genes: F2RL1 FYN LCP1 SNCA VKORC1
Entrez ID		3936	1266
HPRD ID		01082	03848
Ensembl ID		ENSG00000136167	ENSG00000117519
Uniprot IDs		P13796	Q15417
PDB IDs		2D85 5JOJ 5JOL 6VEC	Not available
GO Terms Enriched among Interactors		Cellular Response To Epinephrine Stimulus Response To Epinephrine Excitatory Synapse	Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Activation Cell Activation Regulation Of Hydrogen Peroxide Metabolic Process Phospholipase Binding Glial Cell Projection Regulation Of Protein Localization T Cell Activation Tau Protein Binding Alpha-tubulin Binding Response To Cocaine Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Exocytosis T Cell Activation Involved In Immune Response Regulation Of Establishment Of Protein Localization Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Organelle Organization Lymphocyte Activation Positive Regulation Of Defense Response Cellular Component Maintenance Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Localization Immune Effector Process Positive Regulation Of Renin Secretion Into Blood Stream Response To Alkaloid Actin Filament Cellular Response To Glycine Response To Singlet Oxygen Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Regulation Of Transport Coagulation Blood Coagulation Hemostasis Proteinase-activated Receptor Activity Lymphocyte Activation Involved In Immune Response Myeloid Leukocyte Activation Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Response To Glycine Negative Regulation Of Protein Catabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process