LCP1 and AIF1

Number of citations: 0 (PubMedID 14756805)
Data Source: HPRD (in vitro, in vivo, two hybrid)

		LCP1	AIF1
Name		lymphocyte cytosolic protein 1	allograft inflammatory factor 1
Structure
GO Annotations	Cellular Component	Stress Fiber Ruffle Phagocytic Cup Podosome Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Cell Junction Filopodium Actin Filament Bundle Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Glial Cell Projection	Ruffle Phagocytic Cup Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Membrane Lamellipodium Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm Glial Cell Projection
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding GTPase Binding	Actin Binding Calcium Ion Binding Protein Binding Metal Ion Binding Actin Filament Binding
	Biological Process	T Cell Activation Involved In Immune Response Protein Kinase A Signaling Cell Migration Extracellular Matrix Disassembly Cortical Actin Cytoskeleton Organization Animal Organ Regeneration Regulation Of Intracellular Protein Transport Wound Healing, Spreading Of Cells Actin Filament Bundle Assembly Actin Filament Network Formation Actin Crosslink Formation Positive Regulation Of Podosome Assembly	Microglial Cell Activation Phagocytosis, Engulfment Inflammatory Response Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Rac Protein Signal Transduction Actin Filament Polymerization Parallel Actin Filament Bundle Assembly Positive Regulation Of Cell Migration Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Cellular Response To Oxidative Stress Positive Regulation Of T Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Chemotaxis Actin Filament Bundle Assembly Actin Crosslink Formation Cellular Response To Type II Interferon Negative Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Fibroblast Growth Factor Production Ruffle Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of T Cell Migration
Pathways		Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	None
GWAS		Blood protein levels ( 30072576 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 ) Lymphocyte count ( 32888494 ) Mean platelet volume ( 32888494 ) Non-alcoholic fatty liver disease histology (other) ( 23213074 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Systemic lupus erythematosus ( 26502338 )	Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Appendicular lean mass ( 33097823 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Crohn's disease ( 22936669 ) Heel bone mineral density ( 30598549 ) Height ( 23563607 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Laryngeal squamous cell carcinoma ( 25194280 ) Malaria ( 31844061 ) Mean platelet volume ( 32888494 ) Neonatal lupus ( 20662065 ) Oral cavity cancer ( 27749845 ) Platelet count ( 32888494 ) Rosacea symptom severity ( 29771307 ) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848 ) Takayasu arteritis ( 25604533 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Weight ( 19079260 )
Interacting Genes		7 interacting genes: AIF1 ATXN2 CEBPA CNN3 GCA PDE4B PRKACA	2 interacting genes: ACTA1 LCP1
Entrez ID		3936	199
HPRD ID		01082	03496
Ensembl ID		ENSG00000136167	ENSG00000204472
Uniprot IDs		P13796	I3WTX1 P55008 Q4V347
PDB IDs		2D85 5JOJ 5JOL 6VEC	2D58 2G2B
GO Terms Enriched among Interactors		Cellular Response To Epinephrine Stimulus Response To Epinephrine Excitatory Synapse	Actin Filament Filopodium Stress Fiber Actin Filament Organization Actin Cytoskeleton Supramolecular Fiber Organization Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Actin Filament Network Formation Striated Muscle Thin Filament Actin Filament Bundle Positive Regulation Of Podosome Assembly Protein Kinase A Signaling Regulation Of Podosome Assembly Actin Crosslink Formation Skeletal Muscle Fiber Development Myosin Binding Cortical Actin Cytoskeleton Organization Wound Healing, Spreading Of Cells Phagocytic Cup Glial Cell Projection Myotube Cell Development ADP Binding GTPase Binding Podosome Cortical Cytoskeleton Organization Extracellular Matrix Disassembly Sarcomere Animal Organ Regeneration Cytoskeleton Extracellular Space Actin Filament Bundle Assembly Actin Filament Bundle Organization Striated Muscle Cell Development T Cell Activation Involved In Immune Response Cell Body Structural Constituent Of Cytoskeleton Muscle Cell Development Ruffle Membrane Positive Regulation Of Organelle Assembly Ruffle Extracellular Exosome Blood Microparticle Lymphocyte Activation Involved In Immune Response Regeneration Regulation Of Intracellular Protein Transport Integrin Binding Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response