FDPS and SSMEM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FDPS	SSMEM1
Description		farnesyl diphosphate synthase	serine rich single-pass membrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrial Matrix Peroxisome Cytosol	Membrane
	Molecular Function	RNA Binding Dimethylallyltranstransferase Activity (2E,6E)-farnesyl Diphosphate Synthase Activity Prenyltransferase Activity Protein Binding Transferase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Metal Ion Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Sterol Biosynthetic Process Geranyl Diphosphate Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs		Pamidronic acid Zoledronic acid Alendronic acid Ibandronate Risedronic acid Dimethylallyl Diphosphate Isopentyl Pyrophosphate Geranyl Diphosphate ISOPENTENYL PYROPHOSPHATE Incadronic acid Minodronic acid Farnesyl diphosphate Geranylgeranyl diphosphate
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 34059833) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		9 interacting genes: ABHD16A ATXN1 CEBPA CREB3 EIF4ENIF1 FGFR1 RNF19B SLC30A2 SSMEM1	99 interacting genes: ALG3 APOA2 AQP1 AQP10 AQP3 ARLN ATP6V0C BET1 BLCAP C11orf24 C1QL4 C5 CCL4L2 CDIPT CDS2 CLRN2 CMTM7 CSGALNACT2 CTSA CXCL16 CXCL9 CYB561 CYBC1 DEFB103A DEFB103B DEFB121 EFNA5 EMD ERG28 ERMP1 FAM3C FATE1 FDPS FPR2 GJB2 GPHB5 GPR151 HMOX2 JAGN1 LAT LEPROTL1 LHFPL5 LNPEP MARCHF2 MCRS1 MFSD12 MFSD6 MIP MMD2 MS4A13 NINJ2 NIPAL4 NRM PGAP2 PLPP1 PLPP4 PLPP6 PLPPR2 RHD RTP2 RUSF1 S1PR5 SERP1 SLC35A1 SLC35E3 SLC35H1 SLC38A1 SLC38A7 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC61A1 STX8 TAP1 TAS2R10 TLCD1 TM6SF2 TMEM128 TMEM14A TMEM14C TMEM203 TMEM218 TMEM222 TMEM239 TMEM243 TMEM45A TMEM60 TMEM86A TMEM86B TMEM97 TMPPE TNF TRARG1 UNC93B1 UPK1B VAMP4 YIPF6 ZFPL1
Entrez ID		2224	136263
HPRD ID		00606	14060
Ensembl ID		ENSG00000160752	ENSG00000165120
Uniprot IDs		A0A087X090 P14324	A0A3B3ISA2 Q8WWF3
PDB IDs		1YQ7 1YV5 1ZW5 2F7M 2F89 2F8C 2F8Z 2F92 2F94 2F9K 2OPM 2OPN 2QIS 2RAH 2VF6 3B7L 3CP6 3N1V 3N1W 3N3L 3N45 3N46 3N49 3N5H 3N5J 3N6K 3RYE 3S4J 4DEM 4GA3 4H5C 4H5D 4H5E 4JVJ 4KFA 4KPD 4KPJ 4KQ5 4KQS 4KQU 4L2X 4LFV 4LPG 4LPH 4N1Z 4N9U 4NFI 4NFJ 4NFK 4NG6 4NKE 4NKF 4NUA 4OGU 4P0V 4P0W 4P0X 4PVX 4PVY 4Q23 4QPF 4QXS 4RXA 4XQR 4XQS 4XQT 5CG5 5CG6 5DGM 5DGN 5DGS 5DIQ 5DJP 5DJR 5DJV 5JA0 5JUZ 5JV0 5JV1 5JV2 5KSX 5YGI 6N7Y 6N7Z 6N82 6N83 6OAG 6OAH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Osteoblast Differentiation Stem Cell Proliferation Regulation Of Stem Cell Proliferation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Macromolecule Biosynthetic Process Chemical Homeostasis Positive Regulation Of Cell Differentiation Response To Vitamin B2 C/EBP Complex Integrated Stress Response Signaling Regulation Of Cell Differentiation Embryonic Limb Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Mitotic Cell Cycle DNA Replication Regulation Of Lateral Mesodermal Cell Fate Specification Positive Regulation Of Parathyroid Hormone Secretion Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Positive Regulation Of Deacetylase Activity Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA DNA-templated Transcription Kinase Binding Chromatin Binding Lung Development CHOP-C/EBP Complex White Fat Cell Proliferation Memory Identical Protein Binding Limb Morphogenesis Sequestering Of TGFbeta In Extracellular Matrix Receptor-receptor Interaction Ventricular Zone Neuroblast Division Regulation Of Mitotic Cell Cycle DNA Replication Diphosphate Metabolic Process Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Orbitofrontal Cortex Development Negative Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Phospholipase Activity POZ Domain Binding Zinc Ion Import Into Lysosome Zinc Export Across Plasma Membrane Nuclear Export Nuclear Matrix RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Water Channel Activity Phosphatidate Phosphatase Activity Transmembrane Transport Glycerol Transmembrane Transport Carbohydrate Transport Water Transport Polyol Transmembrane Transport Phospholipid Metabolic Process Alkenylglycerophosphocholine Hydrolase Activity Fluid Transport Phospholipid Dephosphorylation Plasma Membrane Channel Activity Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Diacylglycerol Diphosphate Phosphatase Activity Magnesium Ion Transmembrane Transport Magnesium Ion Transmembrane Transporter Activity Magnesium Ion Transport Carbohydrate Transmembrane Transport Amide Transport Glycerol Channel Activity Lipid Phosphatase Activity Renal Water Absorption One-carbon Compound Transport Urea Transmembrane Transporter Activity Farnesyl Diphosphate Metabolic Process Gap Junction-mediated Intercellular Transport Sphingosine-1-phosphate Phosphatase Activity CCR6 Chemokine Receptor Binding Antigen Processing And Presentation Of Peptide Antigen Response To Bacterium Chemotaxis Lysophosphatidic Acid Phosphatase Activity Inorganic Cation Transmembrane Transporter Activity Renal Water Transport Neutrophil Differentiation Glutamine Transport L-glutamine Transmembrane Transporter Activity Locomotion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Ammonium Channel Activity Urea Transmembrane Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
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