FDPS and SLC30A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FDPS	SLC30A2
Description		farnesyl diphosphate synthase	solute carrier family 30 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrial Matrix Peroxisome Cytosol	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Endosome Membrane Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Zymogen Granule Membrane Secretory Vesicle
	Molecular Function	RNA Binding Dimethylallyltranstransferase Activity (2E,6E)-farnesyl Diphosphate Synthase Activity Prenyltransferase Activity Protein Binding Transferase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Metal Ion Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding Monoatomic Cation Transmembrane Transporter Activity Antiporter Activity Identical Protein Binding Metal Ion Binding Zinc:proton Antiporter Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Sterol Biosynthetic Process Geranyl Diphosphate Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process	Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Response To Zinc Ion Transmembrane Transport Zinc Ion Import Into Organelle Zinc Ion Transmembrane Transport Zinc Export Across Plasma Membrane Zinc Ion Import Into Secretory Vesicle Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Lysosome Zinc Ion Import Into Mitochondrion
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Zinc efflux and compartmentalization by the SLC30 family
Drugs		Pamidronic acid Zoledronic acid Alendronic acid Ibandronate Risedronic acid Dimethylallyl Diphosphate Isopentyl Pyrophosphate Geranyl Diphosphate ISOPENTENYL PYROPHOSPHATE Incadronic acid Minodronic acid Farnesyl diphosphate Geranylgeranyl diphosphate
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 34059833) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		9 interacting genes: ABHD16A ATXN1 CEBPA CREB3 EIF4ENIF1 FGFR1 RNF19B SLC30A2 SSMEM1	67 interacting genes: ABHD16A ADAM33 AQP2 AQP6 ATP13A1 C5orf46 CCL4 CCL4L2 CD40 CD52 CD79A CD99L2 CPLX4 CREB3 CTSA CYB561D2 EBAG9 EMP3 ERGIC3 EVI2B F11R FAM174A FDPS FFAR2 FXYD3 FXYD6 GALNT15 GJA5 GJB2 GJB5 GLB1 GOLT1A GPR161 GPR42 GPRC5D HGFAC KASH5 KCNN4 LMNA LTA LYVE1 MS4A13 NDUFAF1 NRM OPRM1 PCNX2 PLPPR1 PVR SEC22A SELL SERPING1 SLC10A6 SLC16A2 SLC18A1 SLC38A7 SLC39A2 SLC7A1 SLC7A8 TAS2R5 TM4SF18 TMEM107 TMEM52B TMEM60 TMEM86A TNFRSF12A TRARG1 YIPF2
Entrez ID		2224	7780
HPRD ID		00606	18057
Ensembl ID		ENSG00000160752	ENSG00000158014
Uniprot IDs		A0A087X090 P14324	Q9BRI3
PDB IDs		1YQ7 1YV5 1ZW5 2F7M 2F89 2F8C 2F8Z 2F92 2F94 2F9K 2OPM 2OPN 2QIS 2RAH 2VF6 3B7L 3CP6 3N1V 3N1W 3N3L 3N45 3N46 3N49 3N5H 3N5J 3N6K 3RYE 3S4J 4DEM 4GA3 4H5C 4H5D 4H5E 4JVJ 4KFA 4KPD 4KPJ 4KQ5 4KQS 4KQU 4L2X 4LFV 4LPG 4LPH 4N1Z 4N9U 4NFI 4NFJ 4NFK 4NG6 4NKE 4NKF 4NUA 4OGU 4P0V 4P0W 4P0X 4PVX 4PVY 4Q23 4QPF 4QXS 4RXA 4XQR 4XQS 4XQT 5CG5 5CG6 5DGM 5DGN 5DGS 5DIQ 5DJP 5DJR 5DJV 5JA0 5JUZ 5JV0 5JV1 5JV2 5KSX 5YGI 6N7Y 6N7Z 6N82 6N83 6OAG 6OAH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Osteoblast Differentiation Stem Cell Proliferation Regulation Of Stem Cell Proliferation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Macromolecule Biosynthetic Process Chemical Homeostasis Positive Regulation Of Cell Differentiation Response To Vitamin B2 C/EBP Complex Integrated Stress Response Signaling Regulation Of Cell Differentiation Embryonic Limb Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Mitotic Cell Cycle DNA Replication Regulation Of Lateral Mesodermal Cell Fate Specification Positive Regulation Of Parathyroid Hormone Secretion Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Positive Regulation Of Deacetylase Activity Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA DNA-templated Transcription Kinase Binding Chromatin Binding Lung Development CHOP-C/EBP Complex White Fat Cell Proliferation Memory Identical Protein Binding Limb Morphogenesis Sequestering Of TGFbeta In Extracellular Matrix Receptor-receptor Interaction Ventricular Zone Neuroblast Division Regulation Of Mitotic Cell Cycle DNA Replication Diphosphate Metabolic Process Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Orbitofrontal Cortex Development Negative Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Phospholipase Activity POZ Domain Binding Zinc Ion Import Into Lysosome Zinc Export Across Plasma Membrane Nuclear Export Nuclear Matrix RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex	Membrane Transmembrane Transport Plasma Membrane Connexin Complex Gap Junction Channel Activity Gap Junction Renal Water Transport Gap Junction Assembly Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity CCR1 Chemokine Receptor Binding Amino Acid Import Across Plasma Membrane Amino Acid Transmembrane Transporter Activity Amino Acid Transmembrane Transport Thyroid Hormone Transmembrane Transporter Activity Metal Ion Transport Protein Binding Positive Regulation Of Immune System Process Monoatomic Cation Transport Aromatic Amino Acid Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?