S100A12 and AGER

Number of citations of the paper that reports this interaction (PMID 10399917)
289

Data Source:
HPRD (in vitro, in vivo)

		S100A12	AGER
Gene Name		S100 calcium binding protein A12	advanced glycosylation end product-specific receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding RAGE Receptor Binding	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding S100 Protein Binding
	Biological Process	Monocyte Chemotaxis Xenobiotic Metabolic Process Inflammatory Response Neutrophil Chemotaxis Killing Of Cells Of Other Organism Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Innate Immune Response Mast Cell Activation Cytokine Secretion Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity	Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Wounding Neuron Projection Development Innate Immune Response Induction Of Positive Chemotaxis Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs		Olopatadine Amlexanox
Diseases
GWAS			Prostate cancer ( 23535732) Pulmonary function ( 20010834 20010835) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		2 interactors: AGER CACYBP	7 interactors: APP HMGB1 S100A1 S100A12 S100B S100P TTR
Entrez ID		6283	177
HPRD ID		04383	02568
Ensembl ID		ENSG00000163221	ENSG00000204305
Uniprot IDs		P80511	B4DNX3 Q15109 Q3L1S0
PDB IDs		1E8A 1GQM 1ODB 2WC8 2WCB 2WCE 2WCF	1PWI 2BJP 2E5E 2ENS 2L7U 2LE9 2LMB 3CJJ 3O3U 3S58 3S59
Enriched GO Terms of Interacting Partners?			Innate Immune Response Locomotion Immune Response Negative Regulation Of Apoptotic Cell Clearance Defense Response Leukocyte Chemotaxis Movement Of Cell Or Subcellular Component Chemotaxis Positive Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Synaptic Growth At Neuromuscular Junction Response To Stimulus Cell Activation Positive Regulation Of Peptidase Activity Collateral Sprouting In Absence Of Injury Response To External Stimulus Cell Chemotaxis Negative Regulation Of Skeletal Muscle Cell Differentiation Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neuron Projection Development Cell Migration Collateral Sprouting Axon Midline Choice Point Recognition Base-excision Repair, DNA Ligation Thyroid Hormone Transport Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cell Motility Leukocyte Migration Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Axon Choice Point Recognition Neuron Development Central Nervous System Development Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Nervous System Development Regulation Of Binding Cellular Response To Stimulus Learning Or Memory Neuron Remodeling Response To Abiotic Stimulus Response To Methylmercury DNA Ligation Involved In DNA Repair Cognition Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Cell Clearance Neuron Differentiation Cell Projection Organization
Tagcloud ?		albumin alpha1 alpha1pi analytes calpha1 calprotectin cobalamin cp crp diarrhea enteropathies ha hyaluronic hypocobalaminemia hypocobalaminemic ig iga igm immunological mucinosis normocobalaminemia normocobalaminemic pei peis proteinease shar standing suggestive vomiting	algorithm attributable cerebrovascular combine constructed enrichment go iia illuminate incompletely ingredients interesting markov mcl miltiorrhiza module modules network nodes ontology partly pin salvia tan tanshinone toll traf2 traf3 traf6
Tagcloud (Difference) ?		albumin alpha1 alpha1pi analytes calpha1 calprotectin cobalamin cp crp diarrhea enteropathies ha hyaluronic hypocobalaminemia hypocobalaminemic ig iga igm immunological mucinosis normocobalaminemia normocobalaminemic pei peis proteinease shar standing suggestive vomiting	algorithm attributable cerebrovascular combine constructed enrichment go iia illuminate incompletely ingredients interesting markov mcl miltiorrhiza module modules network nodes ontology partly pin salvia tan tanshinone toll traf2 traf3 traf6
Tagcloud (Intersection) ?