S100A12 and CACYBP

Number of citations of the paper that reports this interaction (PubMedID 12042313)
0

Data Source:
HPRD (in vivo)

		S100A12	CACYBP
Description		S100 calcium binding protein A12	calcyclin binding protein
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Secretory Granule Lumen	Nucleus Nuclear Envelope Lumen Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Beta-catenin Destruction Complex Cell Body Extracellular Exosome
	Molecular Function	Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Calcium-dependent Protein Binding RAGE Receptor Binding	Protein Binding Tubulin Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity S100 Protein Binding
	Biological Process	Immune System Process Monocyte Chemotaxis Xenobiotic Metabolic Process Inflammatory Response Neutrophil Chemotaxis Killing Of Cells Of Another Organism Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAP Kinase Activity Endothelial Cell Migration Innate Immune Response Mast Cell Activation Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Heart Development Positive Regulation Of DNA Replication Cardiac Muscle Cell Differentiation Response To Growth Hormone Cellular Response To Calcium Ion Cellular Response To Leukemia Inhibitory Factor
Pathways		TAK1-dependent IKK and NF-kappa-B activation Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs		Olopatadine Amlexanox
Diseases
GWAS		Asthma ( 31619474) Blood protein levels ( 30072576) Matrix metalloproteinase-8 levels ( 29212897)
Interacting Genes		3 interacting genes: AGER CACYBP TNF	22 interacting genes: BEX3 CCR2 CD8A CEBPA ERBB2 FBXO7 HSP90AA1 HSP90B1 MAPK1 NPM1 PEA15 PINX1 PRKCA S100A1 S100A12 S100A6 S100B S100P SIAH1 SIAH2 SKP1 SNCA
Entrez ID		6283	27101
HPRD ID		04383	07316
Ensembl ID		ENSG00000163221	ENSG00000116161
Uniprot IDs		P80511	Q9HB71
PDB IDs		1E8A 1GQM 1ODB 2M9G 2WC8 2WCB 2WCE 2WCF	1X5M 2A25 2A26
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Heterotypic Cell-cell Adhesion Astrocyte Activation S100 Protein Binding Negative Regulation Of Blood Circulation Phagocytic Cup Positive Regulation Of DNA Metabolic Process Microglial Cell Activation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Leukocyte Activation Involved In Inflammatory Response Negative Regulation Of Cytokine Production Positive Regulation Of DNA Replication Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Amyloid-beta Macrophage Activation Response To Amyloid-beta Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction SCF Ubiquitin Ligase Complex Regulation Of DNA Metabolic Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Positive Regulation Of Cytokine Production Positive Regulation Of NF-kappaB Transcription Factor Activity Leukocyte Activation Cellular Response To Amino Acid Stimulus Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Mononuclear Cell Migration Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of JNK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Advanced Glycation End-product Receptor Activity Cell Activation Regulation Of Interleukin-1 Beta Production Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Response To Hormone Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Interleukin-1 Production Regulation Of DNA Replication Response To Amino Acid Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process DNA Damage Response Positive Regulation Of Synaptic Transmission Myeloid Leukocyte Activation	Identical Protein Binding Regulation Of Apoptotic Process Calcium-dependent Protein Binding Regulation Of Programmed Cell Death Regulation Of Protein Stability Protein Catabolic Process S100 Protein Binding Calcium Ion Binding Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Apoptotic Process Positive Regulation Of Defense Response Cell Death Programmed Cell Death Perinuclear Region Of Cytoplasm Proteasomal Protein Catabolic Process Positive Regulation Of Inflammatory Response Protein-containing Complex Regulation Of Protein Ubiquitination Amyloid Fibril Formation Negative Regulation Of Apoptotic Process Nucleus Negative Regulation Of Programmed Cell Death Regulation Of Post-translational Protein Modification Regulation Of Immune System Process Proteolysis Involved In Protein Catabolic Process Protein Homodimerization Activity Positive Regulation Of Protein Localization To Nucleolus Tau Protein Binding Regulation Of Signal Transduction Cytosol Regulation Of Biological Quality Macromolecule Catabolic Process Positive Regulation Of Synaptic Transmission Positive Regulation Of Cell Communication Positive Regulation Of Signaling Sperm Plasma Membrane Long-term Synaptic Potentiation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Defense Response Intracellular Signaling Cassette Neuronal Cell Body Regulation Of Protein Localization To Nucleolus Nucleoplasm RAGE Receptor Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
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