S100A12 and CACYBP

Number of citations of the paper that reports this interaction (PMID 12042313)
20

Data Source:
HPRD (in vivo)

		S100A12	CACYBP
Gene Name		S100 calcium binding protein A12	calcyclin binding protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane	Nuclear Envelope Lumen Nucleoplasm Cytoplasm Beta-catenin Destruction Complex Neuron Projection Cell Body Extracellular Vesicular Exosome
	Molecular Function	Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding RAGE Receptor Binding	Protein Binding Protein Homodimerization Activity
	Biological Process	Monocyte Chemotaxis Xenobiotic Metabolic Process Inflammatory Response Neutrophil Chemotaxis Killing Of Cells Of Other Organism Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Innate Immune Response Mast Cell Activation Cytokine Secretion Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity	Aging Positive Regulation Of DNA Replication Cardiac Muscle Cell Differentiation Response To Growth Hormone Negative Regulation Of Cell Death Cellular Response To Calcium Ion
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs		Olopatadine Amlexanox
Diseases
GWAS
Protein-Protein Interactions		2 interactors: AGER CACYBP	13 interactors: CD8A DYT10 MAPK1 NGFRAP1 PINX1 S100A1 S100A12 S100A6 S100B S100P SIAH1 SIAH2 SKP1
Entrez ID		6283	27101
HPRD ID		04383	07316
Ensembl ID		ENSG00000163221	ENSG00000116161
Uniprot IDs		P80511	Q9HB71
PDB IDs		1E8A 1GQM 1ODB 2WC8 2WCB 2WCE 2WCF	1X5M 2A25 2A26
Enriched GO Terms of Interacting Partners?			Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Positive Regulation Of Intracellular Signal Transduction Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Response To Stimulus Cell Morphogenesis Neuron Differentiation Cell Projection Organization Chemotaxis Locomotion Positive Regulation Of Signal Transduction Cell Cycle Nervous System Development Movement Of Cell Or Subcellular Component Cytotoxic T Cell Differentiation Regulation Of Catalytic Activity Multicellular Organismal Development Generation Of Neurons Neurogenesis Axon Guidance Cellular Response To Stimulus Positive Regulation Of Voltage-gated Calcium Channel Activity MAPK Import Into Nucleus Apoptotic Process Regulation Of Intracellular Signal Transduction Programmed Cell Death Regulation Of Signal Transduction Cell Development Response To External Stimulus Cell Death Death Developmental Process Ubiquitin-dependent Protein Catabolic Process System Development Positive Regulation Of Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Golgi Inheritance Regulation Of Protein Stability Regulation Of Signaling Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity
Tagcloud ?		albumin alpha1 alpha1pi analytes calpha1 calprotectin cobalamin cp crp diarrhea enteropathies ha hyaluronic hypocobalaminemia hypocobalaminemic ig iga igm immunological mucinosis normocobalaminemia normocobalaminemic pei peis proteinease shar standing suggestive vomiting	3months 60s brains brdu bromodeoxyuridine calcyclin candidates comparative diphosphate disabilities ds dysregulated e14 embryos eminence fingerprinting ganglionic ndpk nucleoside p0 pk postnatal proteomic pyruvate rplp0 spots tk transketolase ts1cje
Tagcloud (Difference) ?		albumin alpha1 alpha1pi analytes calpha1 calprotectin cobalamin cp crp diarrhea enteropathies ha hyaluronic hypocobalaminemia hypocobalaminemic ig iga igm immunological mucinosis normocobalaminemia normocobalaminemic pei peis proteinease shar standing suggestive vomiting	3months 60s brains brdu bromodeoxyuridine calcyclin candidates comparative diphosphate disabilities ds dysregulated e14 embryos eminence fingerprinting ganglionic ndpk nucleoside p0 pk postnatal proteomic pyruvate rplp0 spots tk transketolase ts1cje
Tagcloud (Intersection) ?