S100A12

Description		S100 calcium binding protein A12
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Secretory Granule Lumen
	Molecular Function	Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Immune System Process Monocyte Chemotaxis Xenobiotic Metabolic Process Inflammatory Response Neutrophil Chemotaxis Killing Of Cells Of Another Organism Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAP Kinase Activity Endothelial Cell Migration Innate Immune Response Mast Cell Activation Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		TAK1-dependent IKK and NF-kappa-B activation Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs		Olopatadine Amlexanox
Diseases
GWAS		Asthma ( 31619474) Blood protein levels ( 30072576) Matrix metalloproteinase-8 levels ( 29212897)
Novel Interacting Genes		1 novel interacting genes: RBX1
Interacting Genes		3 interacting genes: AGER CACYBP TNF
Entrez ID		6283
HPRD ID		04383
Ensembl ID		ENSG00000163221
Uniprot IDs		P80511
PDB IDs		1E8A 1GQM 1ODB 2M9G 2WC8 2WCB 2WCE 2WCF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Heterotypic Cell-cell Adhesion Astrocyte Activation S100 Protein Binding Negative Regulation Of Blood Circulation Phagocytic Cup Positive Regulation Of DNA Metabolic Process Microglial Cell Activation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Leukocyte Activation Involved In Inflammatory Response Negative Regulation Of Cytokine Production Positive Regulation Of DNA Replication Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Amyloid-beta Macrophage Activation Response To Amyloid-beta Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction SCF Ubiquitin Ligase Complex Regulation Of DNA Metabolic Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Positive Regulation Of Cytokine Production Positive Regulation Of NF-kappaB Transcription Factor Activity Leukocyte Activation Cellular Response To Amino Acid Stimulus Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Mononuclear Cell Migration Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of JNK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Advanced Glycation End-product Receptor Activity Cell Activation Regulation Of Interleukin-1 Beta Production Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Response To Hormone Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Interleukin-1 Production Regulation Of DNA Replication Response To Amino Acid Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process DNA Damage Response Positive Regulation Of Synaptic Transmission Myeloid Leukocyte Activation
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