S100A12

Gene Name		S100 calcium binding protein A12
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding RAGE Receptor Binding
	Biological Process	Monocyte Chemotaxis Xenobiotic Metabolic Process Inflammatory Response Neutrophil Chemotaxis Killing Of Cells Of Other Organism Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Innate Immune Response Mast Cell Activation Cytokine Secretion Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs		Olopatadine Amlexanox
Diseases
GWAS
Protein-protein Interactions		2 interactors: AGER CACYBP
Entrez ID		6283
HPRD ID		04383
Ensembl ID		ENSG00000163221
Uniprot IDs		P80511
PDB IDs		1E8A 1GQM 1ODB 2WC8 2WCB 2WCE 2WCF
Enriched GO Terms of Interacting Partners?
Tagcloud ?		albumin alpha1 alpha1pi analytes calpha1 calprotectin cobalamin cp crp diarrhea enteropathies ha hyaluronic hypocobalaminemia hypocobalaminemic ig iga igm immunological mucinosis normocobalaminemia normocobalaminemic pei peis proteinease shar standing suggestive vomiting