APBA3 and ARF3

Number of citations: 0 (PubMedID 12842896)
Data Source: BioGRID (two hybrid)

		APBA3	ARF3
Name		amyloid beta precursor protein binding family A member 3	ARF GTPase 3
Structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Dendritic Spine Perinuclear Region Of Cytoplasm	Golgi Membrane Cytoplasm Golgi Apparatus Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Enzyme Inhibitor Activity Protein Binding Enzyme Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process	In Utero Embryonic Development Chemical Synaptic Transmission Regulation Of Gene Expression Protein Transport Negative Regulation Of Catalytic Activity	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport
Pathways		Neurexins and neuroligins	Synthesis of PIPs at the Golgi membrane COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
GWAS		Serum alkaline phosphatase levels ( 33547301 )	Bipolar disorder ( 31043756 ) Heel bone mineral density ( 30598549 )
Novel Interactors		2 novel interactors: BDNF GPX4	1 novel interactors: CDK2
Interacting Genes		8 interacting genes: APP ARF3 ARF4 AZI2 BCR EGFR TANK TBKBP1	18 interacting genes: APBA1 APBA2 APBA3 ARFIP1 ARFIP2 ATN1 GGA1 GGA2 GGA3 GORAB KIF23 LINC00632 LNX1 PICK1 SCYL1 SLC2A4 SNCA SUMO2
Entrez ID		9546	377
HPRD ID		05038	00056
Ensembl ID		ENSG00000011132	ENSG00000134287
Uniprot IDs		O96018	P61204
PDB IDs		2YT7 2YT8 5UWS	6II6 8P50
GO Terms Enriched among Interactors		Serine/threonine Protein Kinase Complex Type I Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Collateral Sprouting Response To External Biotic Stimulus Cell Surface Receptor Signaling Pathway Protein-containing Complex Regulation Of Reactive Oxygen Species Metabolic Process Dendritic Spine Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Learning Or Memory Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Dendrite Development Signal Transduction Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Epidermal Growth Factor Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Defense Response To Virus Positive Regulation Of Ubiquitin-specific Protease Activity Cognition Negative Regulation Of Signal Transduction Acetylcholine Receptor Activator Activity Developmental Growth Response To Interleukin-1 Plasma Membrane Bounded Cell Projection Organization Regulation Of MiRNA Transcription Negative Regulation Of Signaling Cellular Localization Lipoprotein Particle Regulation Of Programmed Cell Death Positive Regulation Of Protein Import Negative Regulation Of Cell Communication Nervous System Process ERBB Signaling Pathway Phospholipase D Activator Activity Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Neutrophil Degranulation Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Shc-EGFR Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Programmed Cell Death PTB Domain Binding Axon Collateral Sprouting In Absence Of Injury Regulation Of Protein Import	Protein Domain Specific Binding Protein Transport Intracellular Protein Transport Intracellular Protein Localization Establishment Of Protein Localization Golgi Apparatus Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Localization To Cell Surface Membrane Curvature Sensor Activity Regulation Of Actin Nucleation Phospholipid Binding Golgi To Plasma Membrane Protein Transport Establishment Of Protein Localization To Plasma Membrane Regulation Of Protein Catabolic Process Trans-Golgi Network Golgi To Plasma Membrane Transport Perinuclear Region Of Cytoplasm Presynapse Amyloid-beta Binding Establishment Of Localization In Cell Intracellular Transport Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Multicellular Organism Growth Trans-Golgi Network Membrane Small GTPase Binding Golgi Vesicle Transport Phosphatidylinositol Binding Protein Localization To Membrane Chemical Synaptic Transmission Synaptic Vesicle Vesicle-mediated Transport To The Plasma Membrane Trans-synaptic Signaling Monoamine Transport Phosphatidylinositol-4-phosphate Binding Synaptic Signaling Dendritic Spine Regulation Of Supramolecular Fiber Organization Cellular Localization Presynaptic Modulation Of Chemical Synaptic Transmission Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Retrograde Transport, Endosome To Golgi Locomotory Behavior