CHN1 and HEMK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CHN1	HEMK1
Description		chimerin 1	HemK methyltransferase 1, mitochondrial release factors N(5)-glutamine
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Mitochondrion
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding Ephrin Receptor Binding	Nucleic Acid Binding DNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity
	Biological Process	Signal Transduction Nervous System Development Motor Neuron Axon Guidance Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction	Translational Termination Methylation
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases		Duane retraction syndrome
GWAS		Post bronchodilator FEV1 ( 26634245)	Appendicular lean mass ( 33097823) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cocaine dependence ( 31212010) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Height ( 28552196)
Interacting Genes		16 interacting genes: ACVR1 ADORA2A ANKK1 BMPR1B CDK5 CDK5R1 ERBB2 GTF3C1 HEMK1 HTR6 MAPK1 MAPK8IP2 NCK2 RAC1 RPS3A TGFBR1	18 interacting genes: AKAP8L ASCL3 CDC23 CHN1 CTAG1A CTAG1B HEATR9 INCA1 KRTAP19-1 MAGED1 PEF1 POU2AF1 PSMB4 SHOX SOHLH1 SPRYD7 TUBGCP5 UBQLN2
Entrez ID		1123	51409
HPRD ID		00319	13645
Ensembl ID		ENSG00000128656	ENSG00000114735
Uniprot IDs		P15882	A0A140VK98 B2RA37 Q9Y5R4
PDB IDs		2OSA 3CXL
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Kinase Activity Positive Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cell Projection Organization Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction Schwann Cell Development Regulation Of Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Neuron Projection Guidance Axon Guidance Positive Regulation Of Protein Targeting To Membrane Motor Neuron Axon Guidance Dendrite Protein Kinase 5 Complex Cerebral Cortex Cell Migration Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Targeting To Membrane Positive Regulation Of Apoptotic Process Cell Migration Response To Growth Factor Positive Regulation Of Programmed Cell Death Positive Regulation Of Establishment Of Protein Localization Chemical Synaptic Transmission Plasma Membrane Bounded Cell Projection Organization ErbB-3 Class Receptor Binding Telencephalon Cell Migration Growth Factor Binding Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Forebrain Cell Migration Trans-synaptic Signaling SMAD Binding Synaptic Signaling Dendrite Morphogenesis Neuronal Cell Body Neuron Differentiation Regulation Of Protein Modification Process Positive Regulation Of Supramolecular Fiber Organization Activin Receptor Complex Activin Receptor Activity, Type I Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway
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