CHN1 and CDK5R1

Number of citations of the paper that reports this interaction (PMID 15013773)
1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		CHN1	CDK5R1
Gene Name		chimerin 1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Cyclin-dependent Protein Kinase 5 Holoenzyme Complex Axon Dendrite Growth Cone Neuromuscular Junction Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Contractile Fiber Perinuclear Region Of Cytoplasm
	Molecular Function	SH3/SH2 Adaptor Activity GTPase Activator Activity Metal Ion Binding Ephrin Receptor Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Cyclin-dependent Protein Kinase 5 Activator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Ephrin Receptor Binding
	Biological Process	Small GTPase Mediated Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Signal Transduction Regulation Of Rac GTPase Activity Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Neuron Migration Neuron Cell-cell Adhesion G-protein Coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Cell Proliferation Embryo Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Neuron Differentiation Negative Regulation Of Axon Extension Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Serine Phosphorylation Of STAT3 Protein Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Targeting To Membrane
Pathways		Rho GTPase cycle Signaling by Rho GTPases	Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ACVR1 BMPR1B CDK5 CDK5R1 ERBB2 GTF3C1 HEMK1 MAPK8IP2 NCK2 RAC1 RPS3A TGFBR1	31 interactors: ACTN1 AMPH APP BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 HSP90AA1 KRT40 KRTAP10-3 LMTK2 MAPT MTUS2 NEDD4 NES NOTCH2NL ODF1 PAK1 SET SIAH1 STXBP1 TSC22D4 TTBK1
Entrez ID		1123	8851
HPRD ID		00319	04586
Ensembl ID		ENSG00000128656	ENSG00000176749
Uniprot IDs		P15882	Q15078 Q8N619
PDB IDs		2OSA 3CXL	1H4L 1UNG 1UNH 1UNL 3O0G
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Peptidyl-threonine Phosphorylation Regulation Of Protein Phosphorylation Neuron Projection Morphogenesis Neuron Differentiation Axon Guidance Positive Regulation Of Protein Phosphorylation Cell Development Locomotion Regulation Of Kinase Activity Regulation Of Phosphorylation Neuron Projection Development Cell Projection Morphogenesis Positive Regulation Of Phosphorylation Cell Part Morphogenesis Positive Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Axonogenesis Neuron Development Generation Of Neurons Positive Regulation Of Transferase Activity Signal Transduction By Phosphorylation Axon Development Cell Differentiation Anatomical Structure Morphogenesis Chemotaxis Neurogenesis Positive Regulation Of Cellular Protein Metabolic Process Cell Projection Organization Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Cell Migration Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Serine Phosphorylation Of STAT3 Protein Cell Motility Nervous System Development Regulation Of Cell Death Serine Phosphorylation Of STAT Protein Regulation Of Cell Differentiation	Generation Of Neurons Nervous System Development Neurogenesis Establishment Of Localization In Cell Neuron Projection Development Cellular Localization Neuron Differentiation Cell Differentiation Cell Projection Organization Neuron Development Multicellular Organismal Development Vesicle-mediated Transport Regulation Of Organelle Organization Regulation Of Neurogenesis Establishment Of Organelle Localization Regulation Of Cellular Component Organization Developmental Process Cell Morphogenesis Involved In Differentiation Exocytosis Axonogenesis Synaptic Vesicle Transport Regulation Of Neuron Differentiation Cell Morphogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Morphogenesis Cell Development Regulation Of Cell Development System Development Cell Part Morphogenesis Organelle Localization Neuron Projection Morphogenesis Receptor Catabolic Process Anatomical Structure Development Synapse Organization Regulation Of Cytoskeleton Organization Secretion By Cell Brain Development Receptor Metabolic Process Response To Abiotic Stimulus Head Development Establishment Of Vesicle Localization Negative Regulation Of Neuron Death Vesicle Localization Axon Guidance Regulation Of Cell Differentiation Secretion Anatomical Structure Morphogenesis Regulation Of Cell Cycle Locomotion
Tagcloud ?			10a 200c 30a 30c arhgap5 cd36 cdh2 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Difference) ?			10a 200c 30a 30c arhgap5 cd36 cdh2 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Intersection) ?