RPL23A and IPO5

Number of citations of the paper that reports this interaction (PubMedID 9687515)
73

Data Source:
HPRD (in vitro)

		RPL23A	IPO5
Description		ribosomal protein L23a	importin 5
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Ribosome Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Extracellular Exosome Ribonucleoprotein Complex	Nucleus Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Membrane Nuclear Membrane
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding RRNA Binding Cadherin Binding TORC2 Complex Binding	RNA Binding GTPase Inhibitor Activity Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity
	Biological Process	Cytoplasmic Translation Translation	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Intracellular Protein Transport Protein Transport Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Cell Cycle Cellular Response To Amino Acid Stimulus
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	vRNP Assembly
Drugs		(S)-3-phenyllactic acid Anisomycin Puromycin Artenimol
Diseases
GWAS		Appendicular lean mass ( 33097823) Total cholesterol levels ( 30275531)	Peripheral artery disease ( 26488411) Smooth-surface caries ( 24556642)
Interacting Genes		11 interacting genes: CTPS2 CTTN DUX4 FOXP1 HERC3 IPO5 IPO7 NAP1L1 PTEN TFIP11 TNPO1	31 interacting genes: ACD CAB39 CDC42 DPPA3 DTNBP1 GPRASP3 H1-0 NOSIP NRIP1 NUP153 NUP214 NUP62 NUP98 OGT PRRC2B PTEN RAG2 RAN RANBP2 RNF10 RPL13 RPL23 RPL23A RPL5 RPL7 RPS7 SRP19 SUMO2 TERF1 TINF2 WASL
Entrez ID		6147	3843
HPRD ID		15998	03597
Ensembl ID		ENSG00000198242	ENSG00000065150
Uniprot IDs		P62750	B3KWG6 O00410 Q9BVS9
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6SXO 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8ONY 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FPZ 9FQ0 9G8M 9GMO	6XTE 6XU2 9IM6
Enriched GO Terms of Interacting Partners?		Protein Import Into Nucleus Import Into Nucleus Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Negative Regulation Of Cell Cycle Dendritic Spine Organization Protein Localization To Nucleus Negative Regulation Of Organ Growth Intracellular Protein Transport Neuron Projection Organization Postsynapse Organization Nuclear Transport Nucleocytoplasmic Transport Small GTPase Binding Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Developmental Growth Cytoplasm Establishment Of Protein Localization To Organelle Nuclear Pore Negative Regulation Of Osteoblast Differentiation Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Spliceosomal Complex Disassembly Positive Regulation Of Interleukin-21 Production CTP Synthase Activity 'de Novo' CTP Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Developmental Growth Regulation Of Organ Growth Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission U2-type Post-mRNA Release Spliceosomal Complex Cytoophidium Nucleolus	Cytosolic Ribosome Import Into Nucleus Protein Import Into Nucleus Cytoplasmic Translation Establishment Of Protein Localization To Organelle Nuclear Pore Nucleus Ribonucleoprotein Complex Protein Localization To Nucleus Cytosolic Large Ribosomal Subunit Structural Constituent Of Nuclear Pore RNA Binding Protein Localization To Organelle Nuclear Export Shelterin Complex Nuclear Transport Nucleocytoplasmic Transport RNA Transport Structural Constituent Of Ribosome RNA Export From Nucleus Nucleolus Negative Regulation Of Ubiquitin Protein Ligase Activity Nuclear Telomere Cap Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Nucleoplasm Ribosome Nuclear Inclusion Body Ubiquitin Ligase Inhibitor Activity Telomere Capping Nuclear Pore Nuclear Basket Nucleobase-containing Compound Transport Nuclear Envelope Translation MRNA Transport Intracellular Transport Intracellular Protein Transport Dendritic Spine Morphogenesis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Localization Negative Regulation Of Telomere Maintenance Via Telomerase Nuclear Localization Sequence Binding Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Organelle Localization Nuclear Pore Cytoplasmic Filaments Negative Regulation Of RNA Export From Nucleus Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
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