RPL23A and IPO7

Number of citations of the paper that reports this interaction (PubMedID 9687515)
73

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		RPL23A	IPO7
Description		ribosomal protein L23a	importin 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Ribosome Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Extracellular Exosome Ribonucleoprotein Complex	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding RRNA Binding Cadherin Binding TORC2 Complex Binding	Protein Binding GTPase Regulator Activity Small GTPase Binding Histone Binding SMAD Binding
	Biological Process	Cytoplasmic Translation Translation	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport Innate Immune Response Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Odontoblast Differentiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		(S)-3-phenyllactic acid Anisomycin Puromycin Artenimol
Diseases
GWAS		Appendicular lean mass ( 33097823) Total cholesterol levels ( 30275531)	Interleukin-10 levels ( 22205395)
Interacting Genes		11 interacting genes: CTPS2 CTTN DUX4 FOXP1 HERC3 IPO5 IPO7 NAP1L1 PTEN TFIP11 TNPO1	14 interacting genes: AKTIP CEBPA H1-0 KPNB1 LIMS1 LINC01554 NOSIP PTEN RAN RNF10 RPL23A RPL5 RPS7 SRP19
Entrez ID		6147	10527
HPRD ID		15998	09280
Ensembl ID		ENSG00000198242	ENSG00000205339
Uniprot IDs		P62750	B3KNG9 O95373
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6SXO 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8ONY 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FPZ 9FQ0 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Protein Import Into Nucleus Import Into Nucleus Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Negative Regulation Of Cell Cycle Dendritic Spine Organization Protein Localization To Nucleus Negative Regulation Of Organ Growth Intracellular Protein Transport Neuron Projection Organization Postsynapse Organization Nuclear Transport Nucleocytoplasmic Transport Small GTPase Binding Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Developmental Growth Cytoplasm Establishment Of Protein Localization To Organelle Nuclear Pore Negative Regulation Of Osteoblast Differentiation Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Spliceosomal Complex Disassembly Positive Regulation Of Interleukin-21 Production CTP Synthase Activity 'de Novo' CTP Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Developmental Growth Regulation Of Organ Growth Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission U2-type Post-mRNA Release Spliceosomal Complex Cytoophidium Nucleolus	Cytosolic Ribosome RNA Import Into Nucleus RNA Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Importin-alpha Family Protein Binding Negative Regulation Of Ubiquitin Protein Ligase Activity Ubiquitin Ligase Inhibitor Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Nucleolus Cytoplasmic Translation Regulation Of Proteolysis MRNA 5'-UTR Binding Regulation Of Ubiquitin-protein Transferase Activity Ribonucleoprotein Complex Structural Constituent Of Ribosome Protein-containing Complex Nucleus Spindle Organization Negative Regulation Of Catalytic Activity Ribosome RRNA Binding Positive Regulation Of Binding Protein Domain Specific Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Catalytic Activity Protein Stabilization Cytosolic Large Ribosomal Subunit Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Cell Development Response To Vitamin B2 C/EBP Complex Regulation Of Focal Adhesion Assembly Regulation Of Protein Modification Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Protein Ubiquitination Regulation Of Cell-substrate Junction Organization Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Chromatin DNA Binding CHOP-C/EBP Complex
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