RPL23A and NAP1L1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		RPL23A	NAP1L1
Description		ribosomal protein L23a	nucleosome assembly protein 1 like 1
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Ribosome Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Extracellular Exosome Ribonucleoprotein Complex	Chromatin Nucleus Cytoplasm Membrane Melanosome
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding RRNA Binding Cadherin Binding TORC2 Complex Binding	Chromatin Binding RNA Binding Protein Binding Histone Binding Histone Chaperone Activity
	Biological Process	Cytoplasmic Translation Translation	DNA Replication Nucleosome Assembly Nervous System Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		(S)-3-phenyllactic acid Anisomycin Puromycin Artenimol
Diseases
GWAS		Appendicular lean mass ( 33097823) Total cholesterol levels ( 30275531)	Obesity-related traits ( 23251661) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189)
Interacting Genes		11 interacting genes: CTPS2 CTTN DUX4 FOXP1 HERC3 IPO5 IPO7 NAP1L1 PTEN TFIP11 TNPO1	34 interacting genes: ANKRD23 C1QTNF9 CHORDC1 CREBBP CSNK2A1 CSNK2B DLST DYRK1A EP300 ERCC6 FSD1 GAS2L2 H1-1 H4C1 HBA1 HMGB2 HSPB1 ISG15 LINC01554 MED10 MTNR1A NAP1L2 NR2F6 OGT POT1 RPL23 RPL23A RPS15 SNCA SP1 SUMO2 TERF1 TP53 TPX2
Entrez ID		6147	4673
HPRD ID		15998	01248
Ensembl ID		ENSG00000198242	ENSG00000187109
Uniprot IDs		P62750	B7Z2V4 F5H4R6 F8W543 P55209 Q9H2B0
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6SXO 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8ONY 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FPZ 9FQ0 9G8M 9GMO	7BP5 7UN3 7UN6
Enriched GO Terms of Interacting Partners?		Protein Import Into Nucleus Import Into Nucleus Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Negative Regulation Of Cell Cycle Dendritic Spine Organization Protein Localization To Nucleus Negative Regulation Of Organ Growth Intracellular Protein Transport Neuron Projection Organization Postsynapse Organization Nuclear Transport Nucleocytoplasmic Transport Small GTPase Binding Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Developmental Growth Cytoplasm Establishment Of Protein Localization To Organelle Nuclear Pore Negative Regulation Of Osteoblast Differentiation Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Spliceosomal Complex Disassembly Positive Regulation Of Interleukin-21 Production CTP Synthase Activity 'de Novo' CTP Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Developmental Growth Regulation Of Organ Growth Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission U2-type Post-mRNA Release Spliceosomal Complex Cytoophidium Nucleolus	Rhythmic Process Regulation Of Protein Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Nucleoplasm Negative Regulation Of DNA Metabolic Process Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Cellular Response To Heat Transcription Coactivator Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone H3K27 Acetyltransferase Activity Tau Protein Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Microtubule Polymerization Or Depolymerization Histone H3K18 Acetyltransferase Activity Double-strand Break Repair N-terminal Peptidyl-lysine Acetylation Chromatin Remodeling Cellular Component Assembly Peptide Lactyltransferase (CoA-dependent) Activity Chromatin Organization Regulation Of Cellular Component Organization Protein Localization To Organelle Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Double-strand Break Repair Via Nonhomologous End Joining Symbiont-mediated Disruption Of Host Cell PML Body Circadian Rhythm Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Response To Actinomycin D Negative Regulation Of Proteolysis Positive Regulation Of Metabolic Process Histone Acetyltransferase Complex Negative Regulation Of Catabolic Process Regulation Of Proteolysis Regulation Of Microtubule-based Process Response To Actinomycin D Regulation Of Primary Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Amide Metabolic Process Regulation Of Cell Cycle Process Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Chromatin DNA Binding Regulation Of Protein-containing Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of G1 To G0 Transition
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