HIGD1C and CYB5R1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HIGD1C	CYB5R1
Description		HIG1 hypoxia inducible domain family member 1C	cytochrome b5 reductase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Membrane	Mitochondrion Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Platelet Alpha Granule Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity FAD Binding
	Biological Process	Response To Hypoxia Mitochondrial Respirasome Assembly	Lipid Metabolic Process Steroid Biosynthetic Process Steroid Metabolic Process Bicarbonate Transport Sterol Biosynthetic Process
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1	Platelet degranulation Erythrocytes take up carbon dioxide and release oxygen
Drugs			Flavin adenine dinucleotide
Diseases
GWAS
Interacting Genes		13 interacting genes: APOC1 CIDEB CYB5R1 FARS2 GAD2 MTERF3 NTAQ1 PBX3 RBFA SYT16 TCEA2 TMEM14B TMEM31	8 interacting genes: CYCS HIGD1C SGTA SGTB SLC51B TTC1 UBQLN1 UBQLN4
Entrez ID		613227	51706
HPRD ID		19625	06434
Ensembl ID		ENSG00000214511	ENSG00000159348
Uniprot IDs		A8MV81	Q9UHQ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Very-low-density Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Assembly Regulation Of Triglyceride Metabolic Process Negative Regulation Of Phosphatidylcholine Catabolic Process Posterior Compartment Specification Anterior Compartment Pattern Formation Protein-N-terminal Glutamine Amidohydrolase Activity Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Protein-N-terminal Asparagine Amidohydrolase Activity	TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Protein Catabolic Process Protein Targeting To ER Positive Regulation Of Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Protein Targeting To Membrane Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Protein Catabolic Process Regulation Of Proteolysis Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Nuclear Proteasome Complex Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Apoptosome Negative Regulation Of Autophagosome Maturation Regulation Of Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process BAT3 Complex Binding Positive Regulation Of Protein Glycosylation Cytosolic Proteasome Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Molecular Adaptor Activity Negative Regulation Of ERAD Pathway Regulation Of Protein Metabolic Process Bile Acid Secretion Regulation Of Protein Glycosylation Regulation Of Macroautophagy Positive Regulation Of Proteolysis Establishment Of Protein Localization To Membrane Protein Targeting Positive Regulation Of Protein Catabolic Process Protein-containing Complex Bile Acid Transmembrane Transporter Activity Mitochondrial Electron Transport, Ubiquinol To Cytochrome C K48-linked Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Exit From Endoplasmic Reticulum Mitochondrial Respirasome Assembly Positive Regulation Of Protein Metabolic Process Response To Endoplasmic Reticulum Stress Identical Protein Binding Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Response To Stress
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