HIGD1C and APOC1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HIGD1C	APOC1
Name		HIG1 hypoxia inducible domain family member 1C	apolipoprotein C1
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Membrane	Extracellular Region Endoplasmic Reticulum Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron
	Molecular Function	Protein Binding	Phospholipase Inhibitor Activity Fatty Acid Binding Protein Binding Phosphatidylcholine Binding Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity
	Biological Process	Response To Hypoxia Mitochondrial Respirasome Assembly	Lipid Metabolic Process Triglyceride Metabolic Process Lipid Transport Cholesterol Metabolic Process Negative Regulation Of Triglyceride Catabolic Process Negative Regulation Of Phosphatidylcholine Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Plasma Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Very-low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Lipid Catabolic Process Triglyceride Homeostasis
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1	VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
GWAS		No GWAS studies recorded	Alzheimer's disease ( 17998437 22832961 24755620 30636644 ) Alzheimer's disease (age of onset) ( 22005931 ) Alzheimer's disease biomarkers ( 23419831 ) Alzheimer's disease in hypertension ( 31055733 ) Alzheimer's disease in hypertension-negative individuals ( 31055733 ) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Apolipoprotein Levels ( 23031429 ) Aspartate aminotransferase levels ( 33547301 ) Body fat percentage ( 26833246 ) Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x age interaction ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) C-reactive protein ( 19567438 ) C-reactive protein levels ( 21300955 30388399 ) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Carotid intima media thickness ( 21909108 ) Carotid intima media thickness (maximum) ( 31801372 ) Carotid intima media thickness (mean) ( 31801372 ) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725 ) Cerebral amyloid deposition (PET imaging) ( 26252872 30361487 ) Cerebral amyloid deposition positivity (PET imaging) ( 26252872 ) Cerebral cortex AV-45 amyloid PET measurement ( 31755389 ) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321 ) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321 ) Cerebrospinal AB1-42 levels in normal cognition ( 29274321 ) Cerebrospinal fluid AB1-42 levels ( 28247064 28641921 29274321 30319691 ) Cerebrospinal fluid p-tau levels ( 29274321 ) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321 ) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 30319691 ) Cerebrospinal fluid t-tau levels ( 28641921 29274321 ) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321 ) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921 30319691 ) Cerebrospinal P-tau181p levels ( 28247064 ) Cerebrospinal T-tau levels ( 28247064 ) Cholesterol, total ( 20686565 ) Cingulate cortical amyloid beta load ( 26421299 ) Cognitive impairment test score ( 30319691 ) Coronary artery disease ( 26343387 29212778 32469254 33020668 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Fish- and plant-related diet ( 32066663 ) Fruit consumption ( 32066663 ) HDL cholesterol ( 20686565 ) HDL cholesterol levels ( 28334899 32203549 ) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) High density lipoprotein cholesterol levels ( 30718733 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip index ( 34021172 ) Hippocampal atrophy rate ( 31760383 ) Hippocampal volume ( 29274321 ) Hippocampal volume in Alzheimer's disease dementia ( 29274321 ) Ideal cardiovascular health (clinical) ( 27179730 ) Immature fraction of reticulocytes ( 32888494 ) Lamb consumption ( 32066663 ) LDL cholesterol ( 18193043 18193044 18262040 18802019 19060906 20686565 20864672 26160806 ) LDL cholesterol levels ( 28334899 28371326 ) LDL cholesterol to HDL cholesterol ratio ( 28046027 ) Lipid metabolism phenotypes ( 19936222 22286219 ) Lipid traits ( 24023261 ) Lipoprotein (a) levels ( 33730874 ) Lipoprotein-associated phospholipase A2 activity and mass ( 20442857 22003152 23118302 ) Logical memory (delayed recall) ( 29274321 ) Logical memory (immediate recall) ( 29274321 ) Longevity ( 21740922 ) Low density lipoprotein cholesterol levels ( 28548082 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Meat-related diet ( 32066663 ) Mental health study participation (completed survey) ( 31263887 ) Metabolic syndrome ( 31589552 ) Metabolically unhealthy in normal weight ( 33500527 ) Myocardial infarction ( 26343387 ) Parental longevity (combined parental age at death) ( 29227965 ) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965 ) Parental longevity (father's attained age) ( 29227965 ) Parental longevity (mother's attained age) ( 29227965 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 27863252 ) Quantitative traits ( 19197348 ) Red cell distribution width ( 28957414 ) Refractive error ( 32231278 ) Response to fenofibrate (LDL cholesterol levels) ( 27002377 ) Resting heart rate ( 27798624 ) Serum alkaline phosphatase levels ( 33547301 ) Serum metabolite levels ( 31636271 ) Serum metabolite levels (CMS) ( 31636271 ) Total cholesterol levels ( 28334899 28548082 30275531 ) Triglyceride levels ( 28334899 31217584 32203549 33339817 ) Triglycerides ( 20686565 23726366 ) Type 2 diabetes ( 28869590 ) Verbal declarative memory ( 25648963 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		None recorded	1 novel interactors: AKT1
Interacting Genes		13 interacting genes: APOC1 CIDEB CYB5R1 FARS2 GAD2 MTERF3 NTAQ1 PBX3 RBFA SYT16 TCEA2 TMEM14B TMEM31	30 interacting genes: ACACA ACSF2 APOA1 APOA2 ATP5MJ BCL2L2 CIDEB DBX1 DHRSX FOXD4L3 GSDMA H4C7 HIGD1C LETMD1 MAIP1 MICOS13 MPC2 MTCH2 MTERF3 NFU1 NSG2 RADIL RSAD2 RTP5 SIRPB1 SPG21 SYT16 TEX44 TPRG1 VKORC1
Entrez ID		613227	341
HPRD ID		19625	00131
Ensembl ID		ENSG00000214511	ENSG00000130208
Uniprot IDs		A8MV81	K7EPF9 P02654
PDB IDs		Not available	1ALE 1ALF 1IOJ 1OPP 6DVU 6DXR 6DZ6 6NF3
GO Terms Enriched among Interactors		Very-low-density Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Assembly Regulation Of Triglyceride Metabolic Process Negative Regulation Of Phosphatidylcholine Catabolic Process Posterior Compartment Specification Anterior Compartment Pattern Formation Protein-N-terminal Glutamine Amidohydrolase Activity Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Protein-N-terminal Asparagine Amidohydrolase Activity	Mitochondrion Mitochondrion Organization Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Apolipoprotein Receptor Binding Organophosphate Biosynthetic Process Cellular Response To Lipoprotein Particle Stimulus Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Phagocytosis Protein Oxidation Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Mitochondrial Outer Membrane Regulation Of Intestinal Cholesterol Absorption High-density Lipoprotein Particle Clearance Spherical High-density Lipoprotein Particle Mitochondrial Inner Membrane High-density Lipoprotein Particle Assembly Regulation Of Intestinal Lipid Absorption Organophosphate Metabolic Process High-density Lipoprotein Particle Binding Lipid Homeostasis Apoptotic Mitochondrial Changes Calcium Import Into The Mitochondrion Chylomicron Phospholipid Efflux Regulation Of Intestinal Absorption Protein Insertion Into Membrane Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Phagocytosis Reverse Cholesterol Transport Phosphate-containing Compound Metabolic Process Cellular Response To Prostaglandin E Stimulus Acyl-CoA Metabolic Process Protein Binding Mitochondrial Calcium Ion Transmembrane Transport Establishment Of Protein Localization To Membrane Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling Lipid Droplet Purine-containing Compound Biosynthetic Process Chemical Homeostasis Small Molecule Metabolic Process Phosphatidylcholine Biosynthetic Process Mitochondrial Calcium Ion Homeostasis High-density Lipoprotein Particle Lipid Transporter Activity Cholesterol Transfer Activity Cellular Response To Prostaglandin Stimulus