HIGD1C and GAD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HIGD1C	GAD2
Description		HIG1 hypoxia inducible domain family member 1C	glutamate decarboxylase 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Axon Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
	Molecular Function	Protein Binding	Glutamate Decarboxylase Activity Protein Binding Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding
	Biological Process	Response To Hypoxia Mitochondrial Respirasome Assembly	Gamma-aminobutyrate Shunt Chemical Synaptic Transmission Gamma-aminobutyric Acid Biosynthetic Process Carboxylic Acid Metabolic Process
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1	GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling
Drugs			Pyridoxal phosphate Glutamic acid
Diseases
GWAS			Fasting glucose ( 34059833) Glycated hemoglobin levels ( 34059833) Lean body mass ( 28552196)
Interacting Genes		13 interacting genes: APOC1 CIDEB CYB5R1 FARS2 GAD2 MTERF3 NTAQ1 PBX3 RBFA SYT16 TCEA2 TMEM14B TMEM31	48 interacting genes: ABHD5 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARMC12 BASP1 BSND CACNG1 CALM1 CMTM5 CPLX4 CYB561D1 DERL1 DERL3 DGAT2L6 DMKN F10 FADS6 FAM114A2 FAM163A FTCD GAD1 HIGD1C LDAF1 LIME1 MAL2 MEST MRM3 PBX3 PLIN3 PRKACA PRKCE RDH10 RHEX RPRM SCAMP1 SDR16C5 SEC22A SMPD2 SPG21 SYCE2 SYNGR3 TMEM120B TMEM128 TNFRSF10D TSPAN33
Entrez ID		613227	2572
HPRD ID		19625	11817
Ensembl ID		ENSG00000214511	ENSG00000136750
Uniprot IDs		A8MV81	Q05329 Q5VZ30
PDB IDs			1ES0 2OKK 7LZ6
Enriched GO Terms of Interacting Partners?		Very-low-density Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Assembly Regulation Of Triglyceride Metabolic Process Negative Regulation Of Phosphatidylcholine Catabolic Process Posterior Compartment Specification Anterior Compartment Pattern Formation Protein-N-terminal Glutamine Amidohydrolase Activity Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Protein-N-terminal Asparagine Amidohydrolase Activity	Membrane Lipid Droplet Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Protein Binding Positive Regulation Of Triglyceride Catabolic Process Signal Recognition Particle Binding Substantia Nigra Development Endoplasmic Reticulum Regulation Of Lipid Storage Regulation Of Calcium Ion Transport
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