MAP4K5 and CRKL

Number of citations of the paper that reports this interaction (PMID 10648385)
1

Data Source:
HPRD (in vivo, in vitro)

		MAP4K5	CRKL
Gene Name		mitogen-activated protein kinase kinase kinase kinase 5	v-crk avian sarcoma virus CT10 oncogene homolog-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane	Endosome Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Protein Phosphorylation Activation Of JUN Kinase Activity Intracellular Signal Transduction	Activation Of MAPKK Activity Blood Vessel Development JNK Cascade Ras Protein Signal Transduction Heart Development Organ Morphogenesis Anterior/posterior Pattern Specification Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Thymus Development Parathyroid Gland Development
Pathways			Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation
Drugs
Diseases
GWAS		Cognitive performance ( 20125193)
Protein-Protein Interactions		12 interactors: ABL1 BCR COPS5 CRK CRKL GRB2 HCK NEDD4 SETDB1 TANK TRAF2 ZNF440	71 interactors: ABL1 AOX1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RPL31 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TNS2 TYK2 WAC WAS WIPF1 YY1
Entrez ID		11183	1399
HPRD ID		05374	03596
Ensembl ID		ENSG00000012983	ENSG00000099942
Uniprot IDs		B3KWC4 Q9Y4K4	P46109
PDB IDs			2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of MAPK Cascade Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Innate Immune Response Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Response To Organic Substance Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Endocytosis Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Defense Response Regulation Of Actin Cytoskeleton Organization Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Vesicle-mediated Transport Regulation Of Actin Filament-based Process Regulation Of Phosphorus Metabolic Process Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Response To Stress Cellular Response To Organonitrogen Compound Regulation Of Cytoskeleton Organization Positive Regulation Of Innate Immune Response Regulation Of Endocytosis Protein K63-linked Ubiquitination Intracellular Signal Transduction Signal Transduction Positive Regulation Of Interleukin-2 Production Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Immune System Process Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Immune Response Defense Response Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Metabolic Process Cell Activation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Innate Immune Response Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Locomotion Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Stress Phosphatidylinositol-mediated Signaling Response To Peptide Hormone Positive Regulation Of Phosphorylation Developmental Process
Tagcloud ?			actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting
Tagcloud (Difference) ?			actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting
Tagcloud (Intersection) ?