PPP1R1B and FBXL20

		PPP1R1B	FBXL20
Description		protein phosphatase 1 regulatory inhibitor subunit 1B	F-box and leucine rich repeat protein 20
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Neuronal Cell Body	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse
	Molecular Function	Protein Kinase Inhibitor Activity CAMP-dependent Protein Kinase Inhibitor Activity Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity	Protein Binding
	Biological Process	Response To Amphetamine DNA-templated Transcription Signal Transduction Negative Regulation Of Female Receptivity Locomotory Behavior Visual Learning Intracellular Signal Transduction Response To Morphine Behavioral Response To Cocaine Cellular Response To Cocaine	Behavioral Fear Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis
Pathways		DARPP-32 events DARPP-32 events	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 31619474 31959851) Estimated glomerular filtration rate ( 31015462) Hematocrit ( 32888494) Hemoglobin ( 32888494) Refractive error ( 32231278) Ulcerative colitis ( 20228799)	Asthma ( 31619474) Coronary artery disease ( 29212778) Creatinine levels ( 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) FEV1 ( 30804560) Glomerular filtration rate (creatinine) ( 26831199) Hemoglobin levels ( 32327693) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lung function (FVC) ( 30804560) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Microalbuminuria ( 31511532) Platelet count ( 32888494) Rapid automised naming of pictures ( 30741946) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Ulcerative colitis ( 20228799) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		9 interacting genes: CDK5 CSNK2A1 CSNK2A2 DLGAP4 KLHL6 PPP1CA PRKACA ROBO2 TFCP2	5 interacting genes: BAX BBC3 PIK3C3 SKP1 UBE2D1
Entrez ID		84152	84961
HPRD ID		05097	10951
Ensembl ID		ENSG00000131771	ENSG00000108306
Uniprot IDs		B3KVQ9 Q9UD71	J3KTA1 Q96IG2
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Kinase CK2 Complex Regulation Of Macroautophagy Neuromuscular Junction Protein Serine Kinase Activity Regulation Of Proteolysis Regulation Of Autophagy Regulation Of Protein Catabolic Process Protein Serine/threonine Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling PcG Protein Complex Modulation Of Chemical Synaptic Transmission Protein Kinase Activity Macromolecule Catabolic Process Regulation Of Protein Export From Nucleus Regulation Of Proteasomal Protein Catabolic Process Glutamatergic Synapse Presynapse Hsp90 Protein Binding Kinase Activity Central Nervous System Neuron Development Protein Catabolic Process Double-strand Break Repair Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Glucose Metabolic Process Rhythmic Process Regulation Of Synaptic Vesicle Exocytosis Regulation Of Synapse Organization Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Establishment Of Protein Localization Anatomical Structure Formation Involved In Morphogenesis Regulation Of Chromosome Separation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization Regulation Of Neurotransmitter Secretion Cerebral Cortex Development Negative Regulation Of Catabolic Process RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Apoptotic Process Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Release Of Cytochrome C From Mitochondria Execution Phase Of Apoptosis T Cell Apoptotic Process Positive Regulation Of Leukocyte Apoptotic Process Lymphocyte Apoptotic Process Regulation Of Endoplasmic Reticulum Unfolded Protein Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Release Of Cytochrome C From Mitochondria Leukocyte Apoptotic Process Regulation Of Epithelial Cell Apoptotic Process Regulation Of Lymphocyte Apoptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Homeostatic Proliferation Positive Regulation Of Neuron Apoptotic Process BAX Complex Apoptotic Mitochondrial Changes Release Of Matrix Enzymes From Mitochondria Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage B Cell Negative Selection Positive Regulation Of Motor Neuron Apoptotic Process BAK Complex Regulation Of Response To Endoplasmic Reticulum Stress Glycolipid Metabolic Process Response To Radiation B Cell Receptor Apoptotic Signaling Pathway B Cell Homeostatic Proliferation Signal Transduction By P53 Class Mediator Phosphatidylinositol Biosynthetic Process Protein K48-linked Ubiquitination Apoptotic Process Involved In Embryonic Digit Morphogenesis Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Regulation Of Mitochondrion Organization Regulation Of Nitrogen Utilization Apoptotic Process Involved In Mammary Gland Involution Retinal Cell Programmed Cell Death F-box Domain Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Programmed Cell Death Response To Ionizing Radiation Positive Regulation Of B Cell Apoptotic Process
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