SLIT1

Gene Name		slit homolog 1 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space
	Molecular Function	Calcium Ion Binding Heparan Sulfate Proteoglycan Binding Roundabout Binding
	Biological Process	Axon Guidance Motor Neuron Axon Guidance Spinal Cord Development Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Retinal Ganglion Cell Axon Guidance Dorsal/ventral Axon Guidance Establishment Of Nucleus Localization Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Forebrain Morphogenesis Negative Chemotaxis Negative Regulation Of Synapse Assembly
Pathways		Axon guidance Netrin-1 signaling
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-protein Interactions		3 interactors: ATN1 GPC1 ROBO1
Entrez ID		6585
HPRD ID		04773
Ensembl ID		ENSG00000187122
Uniprot IDs		A6H8V1 O75093
PDB IDs
Enriched GO Terms of Interacting Partners?		Locomotion Heparan Sulfate Proteoglycan Catabolic Process Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Negative Chemotaxis Movement Of Cell Or Subcellular Component Proteoglycan Catabolic Process Roundabout Signaling Pathway Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Mammary Duct Terminal End Bud Growth Axon Choice Point Recognition Axon Guidance Tangential Migration From The Subventricular Zone To The Olfactory Bulb Nervous System Development Olfactory Bulb Interneuron Development Positive Regulation Of Skeletal Muscle Cell Differentiation Maintenance Of Cell Polarity Axonogenesis Glycoprotein Catabolic Process Toxin Metabolic Process Cerebral Cortex Tangential Migration Axon Development Cell Morphogenesis Involved In Neuron Differentiation Olfactory Bulb Interneuron Differentiation Chemotaxis Neuron Projection Morphogenesis Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Skeletal Muscle Cell Differentiation Negative Chemotaxis Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Negative Regulation Of Chemotaxis Neuron Projection Development Positive Regulation Of Skeletal Muscle Tissue Development Cell Migration Cell Projection Morphogenesis Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Myelin Assembly Blood Vessel Endothelial Cell Migration Cell Motility Heparan Sulfate Proteoglycan Metabolic Process Forebrain Neuron Development Substrate-dependent Cell Migration Neuron Recognition Negative Regulation Of Cytokine-mediated Signaling Pathway Neuron Development
Tagcloud ?		attractant attractants attractively away axons connect constrain dcc explant explanted fasciculus grow longitudinal longitudinally midline navigation netrin netrin1 pioneer positioned pull push repellents repulsive robo slit2 trajectories ventrally