SLIT1 and GPC1

Number of citations of the paper that reports this interaction (PMID 10364234)
17

Data Source:
HPRD (in vivo)

		SLIT1	GPC1
Gene Name		slit homolog 1 (Drosophila)	glypican 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Proteinaceous Extracellular Matrix Extracellular Space Endosome Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Anchored Component Of Membrane Lysosomal Lumen Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Heparan Sulfate Proteoglycan Binding Roundabout Binding	Copper Ion Binding Fibroblast Growth Factor Binding Laminin Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Axon Guidance Motor Neuron Axon Guidance Spinal Cord Development Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Retinal Ganglion Cell Axon Guidance Dorsal/ventral Axon Guidance Establishment Of Nucleus Localization Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Forebrain Morphogenesis Negative Chemotaxis Negative Regulation Of Synapse Assembly	Retinoid Metabolic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Axon Guidance Phototransduction, Visible Light Pathogenesis Schwann Cell Differentiation Heparan Sulfate Proteoglycan Catabolic Process Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Myelin Assembly Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Axon guidance Netrin-1 signaling	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Axon guidance Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Inactivation of Cdc42 and Rac Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA Activation of Rac MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Role of Abl in Robo-Slit signaling Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates Signaling by Robo receptor HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Brain imaging in schizophrenia (interaction) ( 19023125)
Protein-Protein Interactions		3 interactors: ATN1 GPC1 ROBO1	5 interactors: APP COL18A1 SLIT1 SLIT2 VEGFA
Entrez ID		6585	2817
HPRD ID		04773	02671
Ensembl ID		ENSG00000187122	ENSG00000063660
Uniprot IDs		A6H8V1 O75093	P35052
PDB IDs			4ACR 4AD7
Enriched GO Terms of Interacting Partners?		Locomotion Heparan Sulfate Proteoglycan Catabolic Process Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Negative Chemotaxis Movement Of Cell Or Subcellular Component Proteoglycan Catabolic Process Roundabout Signaling Pathway Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Mammary Duct Terminal End Bud Growth Axon Choice Point Recognition Axon Guidance Tangential Migration From The Subventricular Zone To The Olfactory Bulb Nervous System Development Olfactory Bulb Interneuron Development Positive Regulation Of Skeletal Muscle Cell Differentiation Maintenance Of Cell Polarity Axonogenesis Glycoprotein Catabolic Process Toxin Metabolic Process Cerebral Cortex Tangential Migration Axon Development Cell Morphogenesis Involved In Neuron Differentiation Olfactory Bulb Interneuron Differentiation Chemotaxis Neuron Projection Morphogenesis Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Skeletal Muscle Cell Differentiation Negative Chemotaxis Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Negative Regulation Of Chemotaxis Neuron Projection Development Positive Regulation Of Skeletal Muscle Tissue Development Cell Migration Cell Projection Morphogenesis Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Myelin Assembly Blood Vessel Endothelial Cell Migration Cell Motility Heparan Sulfate Proteoglycan Metabolic Process Forebrain Neuron Development Substrate-dependent Cell Migration Neuron Recognition Negative Regulation Of Cytokine-mediated Signaling Pathway Neuron Development	Cell Morphogenesis Involved In Differentiation Regulation Of Developmental Growth Regulation Of Retinal Ganglion Cell Axon Guidance Cell Morphogenesis Regulation Of Axon Extension Dorsal/ventral Axon Guidance Axon Guidance Developmental Cell Growth Growth Axonogenesis Regulation Of Neuron Differentiation Axon Extension Involved In Axon Guidance Regulation Of Cell Size Axon Development Regulation Of Chemotaxis Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Developmental Growth Involved In Morphogenesis Regulation Of Growth Cell Growth Neuron Projection Morphogenesis Cell Development Regulation Of Axonogenesis Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Neurogenesis Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Behavior Negative Regulation Of Neuron Differentiation Negative Chemotaxis Neuron Projection Development Cell Migration Involved In Sprouting Angiogenesis Retinal Ganglion Cell Axon Guidance Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Negative Regulation Of Axon Extension Anatomical Structure Morphogenesis Negative Regulation Of Chemotaxis Neuron Development Regulation Of Vascular Permeability Organ Morphogenesis Developmental Growth Negative Regulation Of Neurogenesis Blood Vessel Endothelial Cell Migration Motor Neuron Axon Guidance Neuron Differentiation Regulation Of Cellular Component Size Angiogenesis Negative Regulation Of Cell Development
Tagcloud ?		attractant attractants attractively away axons connect constrain dcc explant explanted fasciculus grow longitudinal longitudinally midline navigation netrin netrin1 pioneer positioned pull push repellents repulsive robo slit2 trajectories ventrally	arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Difference) ?		attractant attractants attractively away axons connect constrain dcc explant explanted fasciculus grow longitudinal longitudinally midline navigation netrin netrin1 pioneer positioned pull push repellents repulsive robo slit2 trajectories ventrally	arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Intersection) ?