SLIT1 and CHRDL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLIT1	CHRDL2
Description		slit guidance ligand 1	chordin like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Calcium Ion Binding Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding Roundabout Binding	Protein Binding BMP Binding
	Biological Process	Nuclear Migration Nervous System Development Axonogenesis Axon Guidance Motor Neuron Axon Guidance Spinal Cord Development Olfactory Bulb Development Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Tangential Migration From The Subventricular Zone To The Olfactory Bulb Telencephalon Cell Migration Cell Differentiation Retinal Ganglion Cell Axon Guidance Dorsal/ventral Axon Guidance Neuron Projection Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Forebrain Morphogenesis Negative Chemotaxis Negative Regulation Of Synapse Assembly	Ossification Cell Differentiation Negative Regulation Of BMP Signaling Pathway System Development Cartilage Development
Pathways		Netrin-1 signaling Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Bipolar disorder ( 28115744) Diastolic blood pressure (alcohol consumption interaction) ( 24376456) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Obesity-related traits ( 23251661)	Allergic rhinitis ( 25085501) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Microalbuminuria ( 26631737) Spine bone size ( 31053729)
Interacting Genes		17 interacting genes: ADAMTSL4 ATN1 CHRDL2 CYSRT1 FHL5 FXR1 GPC1 HOXA1 KRTAP1-1 KRTAP10-8 KRTAP13-2 KRTAP13-3 MEOX2 MTNR1A ROBO1 TRIM42 ZNF620	21 interacting genes: BANP BMP2 BMP4 BMP5 BMP6 BMP7 CHRD ENKD1 FAH FAM90A1 GDF5 GPSM3 HOXA1 INHBA MAPRE3 OTX1 PIK3R3 POU4F2 SLIT1 ZNF417 ZNF587
Entrez ID		6585	25884
HPRD ID		04773	09881
Ensembl ID		ENSG00000187122	ENSG00000054938
Uniprot IDs		A6H8V1 O75093	Q6WN34
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament	Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction BMP Receptor Binding BMP Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Growth Factor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Activator Complex Cartilage Development Cytokine Activity Ossification Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Differentiation Ameloblast Differentiation Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Positive Regulation Of Neuron Differentiation Skeletal System Development Regulation Of Aldosterone Biosynthetic Process Regulation Of Neuron Differentiation Positive Regulation Of Bone Mineralization Endocardial Cushion Formation Type B Pancreatic Cell Development Positive Regulation Of Biomineral Tissue Development Regulation Of Cell Differentiation Positive Regulation Of Ossification Heart Development Negative Regulation Of Developmental Process Regulation Of Osteoblast Differentiation Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Epithelial Cell Differentiation Protein Serine/threonine Kinase Activator Activity Regulation Of Cartilage Development Positive Regulation Of Osteoblast Differentiation Regulation Of Locomotion Regulation Of Ketone Biosynthetic Process Regulation Of Bone Mineralization Regulation Of Hormone Biosynthetic Process Anatomical Structure Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Neural Fold Elevation Formation Positive Regulation Of Cell Differentiation Regulation Of Animal Organ Formation Odontogenesis Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Aldosterone Biosynthetic Process
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