PPCDC and CENPT

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PPCDC	CENPT
Gene Name		phosphopantothenoylcysteine decarboxylase	centromere protein T
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytosol
	Molecular Function	Phosphopantothenoylcysteine Decarboxylase Activity	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Coenzyme Biosynthetic Process Coenzyme A Biosynthetic Process Pantothenate Metabolic Process Small Molecule Metabolic Process	Mitotic Cell Cycle Nucleosome Assembly Chromosome Segregation Mitotic Nuclear Division CENP-A Containing Nucleosome Assembly Chromosome Organization Cell Division Kinetochore Assembly
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Vitamin B5 (pantothenate) metabolism Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Coenzyme A biosynthesis Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism	Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494) Caffeine consumption ( 21490707)
Protein-Protein Interactions		8 interactors: CENPT DBI FOXR1 PPIG SREK1IP1 TXN2 WDYHV1 ZNF232	6 interactors: APP COPS5 DHX29 PPCDC SNCB TCEA2
Entrez ID		60490	80152
HPRD ID		14377	07811
Ensembl ID		ENSG00000138621	ENSG00000102901
Uniprot IDs		H3BRQ0 Q96CD2	B3KPB2 Q96BT3
PDB IDs		1QZU
Enriched GO Terms of Interacting Partners?			Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Translation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Synapse Organization Exosomal Secretion Collateral Sprouting Axon Midline Choice Point Recognition Nucleobase-containing Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Translational Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Axon Choice Point Recognition Heterocycle Metabolic Process Cullin Deneddylation Cellular Nitrogen Compound Metabolic Process Neuron Remodeling Protein Deneddylation Exocytosis Pantothenate Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Coenzyme A Biosynthetic Process Cellular Copper Ion Homeostasis Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Expression Copper Ion Homeostasis Suckling Behavior Cellular Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Secretion By Cell Coenzyme A Metabolic Process Dopamine Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Transcription From RNA Polymerase II Promoter
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