PPCDC and CENPT

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		PPCDC	CENPT
Description		phosphopantothenoylcysteine decarboxylase	centromere protein T
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GO Annotations	Cellular Component	Cytosol Phosphopantothenoylcysteine Decarboxylase Complex	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Nuclear Body
	Molecular Function	Catalytic Activity Phosphopantothenoylcysteine Decarboxylase Activity Protein Binding FMN Binding Lyase Activity Carboxy-lyase Activity Identical Protein Binding	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Coenzyme A Biosynthetic Process	Mitotic Cell Cycle Chromosome Segregation Chromosome Organization Cell Division Kinetochore Assembly
Pathways		Coenzyme A biosynthesis	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Flavin mononucleotide Pantothenoylaminoethenethiol
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Apolipoprotein A1 levels ( 32203549) Blood trace element (Zn levels) ( 23720494) Caffeine consumption ( 21490707) Coffee consumption (cups per day) ( 31837886) Heel bone mineral density ( 30598549) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Multisite chronic pain ( 33830993) Neutrophil count ( 32888494) Platelet count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systemic lupus erythematosus ( 26502338) White blood cell count ( 32888494)	Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		13 interacting genes: CENPT DBI DDIT4L FOXR1 NAA80 NTAQ1 PLEKHF2 PPIG PSMA1 SREK1IP1 TXN2 UBE2I ZNF232	8 interacting genes: APP CENPS COPS5 DHX29 H3C1 PPCDC SNCB TCEA2
Entrez ID		60490	80152
HPRD ID		14377	07811
Ensembl ID		ENSG00000138621	ENSG00000102901
Uniprot IDs		H3BQB0 H3BRQ0 H3BSE3 H3BU63 Q96CD2	B3KPB2 Q96BT3
PDB IDs		1QZU	7QOO 7R5S 7XHN 7XHO 7YWX
Enriched GO Terms of Interacting Partners?			Transition Metal Ion Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Translation Initiation Factor Activity Phosphopantothenoylcysteine Decarboxylase Activity Phosphopantothenoylcysteine Decarboxylase Complex Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Protein Heterodimerization Activity Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Macrophage Migration Inhibitory Factor Binding Translational Initiation Nitric-oxide Synthase Complex
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