PPCDC and NAA80

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPCDC	NAA80
Description		phosphopantothenoylcysteine decarboxylase	N-alpha-acetyltransferase 80, NatH catalytic subunit
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GO Annotations	Cellular Component	Cytosol Phosphopantothenoylcysteine Decarboxylase Complex	Cytoplasm Cytosol
	Molecular Function	Catalytic Activity Phosphopantothenoylcysteine Decarboxylase Activity Protein Binding FMN Binding Lyase Activity Carboxy-lyase Activity Identical Protein Binding	Protein-N-terminal Amino-acid Acetyltransferase Activity Protein Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Acetyl-CoA Binding
	Biological Process	Coenzyme A Biosynthetic Process	Protein Acetylation Regulation Of Actin Polymerization Or Depolymerization N-terminal Peptidyl-aspartic Acid Acetylation N-terminal Peptidyl-glutamic Acid Acetylation Actin Modification
Pathways		Coenzyme A biosynthesis
Drugs		Flavin mononucleotide Pantothenoylaminoethenethiol
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Apolipoprotein A1 levels ( 32203549) Blood trace element (Zn levels) ( 23720494) Caffeine consumption ( 21490707) Coffee consumption (cups per day) ( 31837886) Heel bone mineral density ( 30598549) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Multisite chronic pain ( 33830993) Neutrophil count ( 32888494) Platelet count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systemic lupus erythematosus ( 26502338) White blood cell count ( 32888494)
Interacting Genes		13 interacting genes: CENPT DBI DDIT4L FOXR1 NAA80 NTAQ1 PLEKHF2 PPIG PSMA1 SREK1IP1 TXN2 UBE2I ZNF232	5 interacting genes: APP EMG1 PM20D2 PPCDC STK16
Entrez ID		60490	24142
HPRD ID		14377	06148
Ensembl ID		ENSG00000138621	ENSG00000243477
Uniprot IDs		H3BQB0 H3BRQ0 H3BSE3 H3BU63 Q96CD2	Q6IAP1 Q93015
PDB IDs		1QZU	6NAS 6NBE 6NBW
Enriched GO Terms of Interacting Partners?			Golgi-associated Vesicle Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway RRNA (pseudouridine) Methyltransferase Activity Phosphopantothenoylcysteine Decarboxylase Activity Phosphopantothenoylcysteine Decarboxylase Complex Para-aminobenzoyl-glutamate Hydrolase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Identical Protein Binding Nucleologenesis Folic Acid Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Nucleolus Organization Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Coenzyme A Biosynthetic Process Peptidase Activator Activity Cellular Response To Growth Factor Stimulus Cellular Response To Manganese Ion RRNA Base Methylation Antifungal Humoral Response Nuclear Envelope Lumen
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