APOBEC3G and RNF7

Number of citations of the paper that reports this interaction (PubMedID 31253590)
89

Data Source:
BioGRID (enzymatic study)

		APOBEC3G	RNF7
Description		apolipoprotein B mRNA editing enzyme catalytic subunit 3G	ring finger protein 7
Image
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Apolipoprotein B MRNA Editing Enzyme Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding DCTP Deaminase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding	Copper Ion Binding Protein Binding Zinc Ion Binding Transferase Activity NEDD8 Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Immune System Process Transposable Element Silencing Negative Regulation Of Macromolecule Biosynthetic Process Base Conversion Or Substitution Editing Cytidine To Uridine Editing Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Viral Process Defense Response To Virus DNA Cytosine Deamination Antiviral Innate Immune Response Defense Response To Symbiont	Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Layer Formation In Cerebral Cortex Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Reelin-mediated Signaling Pathway Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Innate Immune Response Protein Neddylation Phosphocreatine Biosynthetic Process Defense Response To Virus Response To Redox State Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Protein K11-linked Ubiquitination Negative Regulation Of Focal Adhesion Disassembly CGAS/STING Signaling Pathway Regulation Of Neuron Migration
Pathways			Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Inflammatory bowel disease ( 23128233)	Hepatitis C induced liver fibrosis ( 22841784) Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		8 interacting genes: APOBEC3F APP ARIH2 CUL5 HDAC6 PRKACA PTN RNF7	43 interacting genes: APOBEC3F APOBEC3G ARIH2 ASB11 BTRC CASP7 CBFB CDC34 CHFR CREBBP CSNK2A1 CSNK2B CUL1 CUL2 CUL3 CUL5 CYCS ELOC ERBIN GEM GHR GLMN IKBKG ITM2C MKRN3 MNAT1 NEDD4 NEDD4L PLA2G15 PMAIP1 SOCS3 TRIM46 TRIM8 UBA3 UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2F UBE2L3 UBE2M UBE2Q1 USP40
Entrez ID		60489	9616
HPRD ID		06172	04840
Ensembl ID		ENSG00000239713	ENSG00000114125
Uniprot IDs		Q9HC16	Q9UBF6
PDB IDs		2JYW 2KBO 2KEM 3E1U 3IQS 3IR2 3V4J 3V4K 4ROV 4ROW 5ZVA 5ZVB 6BUX 6BWY 6K3J 6K3K 7UXD 8CX0 8CX1 8CX2 8H0I 8J62	2ECL 7ONI
Enriched GO Terms of Interacting Partners?		Cul5-RING Ubiquitin Ligase Complex Positive Regulation Of Cellular Component Organization Response To Stress Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Focal Adhesion Disassembly Positive Regulation Of Locomotion Regulation Of Cell Junction Assembly Innate Immune Response Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Defense Response To Virus Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Developmental Growth Developmental Cell Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Virus Response To Parathyroid Hormone Growth Hormone Receptor Signaling Pathway Via JAK-STAT Collateral Sprouting Regulation Of Cell Migration Layer Formation In Cerebral Cortex Negative Regulation Of Focal Adhesion Assembly Response To Auditory Stimulus Regulation Of Cell Motility Immune System Process Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Modulation Of Chemical Synaptic Transmission Regulation Of Locomotion Regulation Of Establishment Of Protein Localization Cell Surface Receptor Signaling Pathway Molecular Function Activator Activity Response To Other Organism Growth Hormone Receptor Signaling Pathway Negative Regulation Of Multicellular Organismal Process Proteolysis CGAS/STING Signaling Pathway Immune Response Positive Regulation Of Focal Adhesion Assembly Regulation Of Chemotaxis	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Protein K48-linked Ubiquitination Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cullin-RING Ubiquitin Ligase Complex Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity Nucleus Cell Cycle Phase Transition Cul5-RING Ubiquitin Ligase Complex Protein K11-linked Ubiquitination Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Mitotic Cell Cycle Phase Transition NEDD8 Transferase Activity Cytosol Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Virus Defense Response To Virus Intracellular Signal Transduction Protein K63-linked Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway NEDD8 Conjugating Enzyme Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Regulation Of Protein Metabolic Process Cul2-RING Ubiquitin Ligase Complex Ubiquitin-like Protein Transferase Activity Protein Destabilization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?