Wiki-Pi
About
Search
People
Updates
Search
FKBP8 and MTOR
Number of citations of the paper that reports this interaction (PubMedID
24205284
)
38
Data Source:
BioGRID
(affinity chromatography technology, pull down)
FKBP8
MTOR
Description
FKBP prolyl isomerase 8
mechanistic target of rapamycin kinase
Image
GO Annotations
Cellular Component
Mitochondrion
Mitochondrial Envelope
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Endomembrane System
Membrane
Mitochondrial Membrane
Protein-containing Complex
Golgi Membrane
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Lysosome
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Endomembrane System
Membrane
PML Body
Dendrite
Cytoplasmic Vesicle
TORC1 Complex
TORC2 Complex
Phagocytic Vesicle
Serine/threonine Protein Kinase Complex
Molecular Function
Peptidyl-prolyl Cis-trans Isomerase Activity
Protein Binding
Calmodulin Binding
Isomerase Activity
Identical Protein Binding
Protein Folding Chaperone
Metal Ion Binding
Disordered Domain Specific Binding
Nucleotide Binding
Inositol Hexakisphosphate Binding
RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding
RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding
RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding
TFIIIC-class Transcription Factor Complex Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Identical Protein Binding
Ribosome Binding
Transmembrane Transporter Binding
Protein-containing Complex Binding
Phosphoprotein Binding
Protein Serine Kinase Activity
Biological Process
Cell Fate Specification
Negative Regulation Of Protein Phosphorylation
Protein Folding
Apoptotic Process
Signal Transduction
Smoothened Signaling Pathway
Dorsal/ventral Pattern Formation
Regulation Of Gene Expression
Dorsal/ventral Neural Tube Patterning
Neural Tube Development
BMP Signaling Pathway
Regulation Of BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Multicellular Organism Growth
Intracellular Signal Transduction
Camera-type Eye Development
Negative Regulation Of Apoptotic Process
Neuron Fate Specification
Regulation Of Macromolecule Metabolic Process
Protein Localization To Mitochondrion
Regulation Of Mitophagy
Autophagosome Assembly
Regulation Of Cell Growth
Cytoplasmic Translation
T-helper 1 Cell Lineage Commitment
Heart Morphogenesis
Heart Valve Morphogenesis
Energy Reserve Metabolic Process
'de Novo' Pyrimidine Nucleobase Biosynthetic Process
Regulation Of Translational Initiation
Ubiquitin-dependent Protein Catabolic Process
Inflammatory Response
DNA Damage Response
Cytoskeleton Organization
Lysosome Organization
Germ Cell Development
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Regulation Of Cell Size
Cellular Response To Starvation
Response To Heat
Response To Virus
Post-embryonic Development
Positive Regulation Of Biosynthetic Process
Regulation Of Autophagy
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Myotube Differentiation
Macroautophagy
Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Regulation Of Lipid Metabolic Process
Neuronal Action Potential
Cell Projection Organization
Positive Regulation Of Cell Growth
Positive Regulation Of Actin Filament Polymerization
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
T Cell Costimulation
Ruffle Organization
Regulation Of Myelination
Protein Destabilization
Response To Nutrient Levels
Cellular Response To Nutrient Levels
Cellular Response To Nutrient
TOR Signaling
Response To Insulin
Cellular Response To Insulin Stimulus
Regulation Of Actin Cytoskeleton Organization
Calcineurin-NFAT Signaling Cascade
Cellular Response To Amino Acid Starvation
Multicellular Organism Growth
TORC1 Signaling
TORC2 Signaling
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Response To Amino Acid
Anoikis
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Differentiation
Regulation Of Osteoclast Differentiation
Positive Regulation Of Translation
Negative Regulation Of Cell Size
Positive Regulation Of Glycolytic Process
Negative Regulation Of Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase III
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Lipid Biosynthetic Process
Behavioral Response To Pain
Oligodendrocyte Differentiation
Positive Regulation Of Oligodendrocyte Differentiation
Cardiac Muscle Tissue Development
Protein Stabilization
Voluntary Musculoskeletal Movement
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Keratinocyte Migration
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cardiac Cell Development
Cardiac Muscle Cell Development
Cardiac Muscle Contraction
Cellular Response To Methionine
Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Amino Acid Stimulus
Cellular Response To L-leucine
Cellular Response To Hypoxia
Cellular Response To Osmotic Stress
Regulation Of Cellular Response To Stress
Regulation Of Membrane Permeability
Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
Antibacterial Innate Immune Response
Regulation Of Cellular Response To Heat
Negative Regulation Of Protein Localization To Nucleus
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Negative Regulation Of TORC2 Signaling
Regulation Of Locomotor Rhythm
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Positive Regulation Of Cytoplasmic Translational Initiation
Regulation Of Lysosome Organization
Negative Regulation Of Lysosome Organization
Positive Regulation Of Pentose-phosphate Shunt
Cellular Response To Leucine Starvation
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cytoplasmic Translation
Regulation Of Autophagosome Assembly
Pathways
Ub-specific processing proteases
PIP3 activates AKT signaling
Macroautophagy
MTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of PTEN gene transcription
Amino acids regulate mTORC1
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Pimecrolimus
Sirolimus
Everolimus
Rimiducid
SF1126
XL765
Ridaforolimus
Temsirolimus
GSK-1059615
Fostamatinib
Oleandrin
Diseases
GWAS
Plasma parathyroid hormone levels (
30134803
)
Urinary potassium excretion (
31409800
)
A body shape index (
34021172
)
Beard thickness (
26926045
)
Body mass index (
25673413
)
Body mass index and type 2 diabetes (pairwise) (
33619380
)
Corneal curvature (
24963161
)
Heel bone mineral density (
28869591
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Interacting Genes
52 interacting genes:
AQP6
ARHGEF5
ARL13B
ATP13A2
BCL2
BCL2L1
BIK
BNIPL
CD79A
CIDEB
CLCN1
CXCR2
CYB561
CYBRD1
EBP
EGFR
ELOVL4
ERBB2
ERGIC3
FAM174A
FGF14
GPR37
JAGN1
MAPK14
MTOR
OGT
PEX12
PLN
PPP3CA
PSMC1
PSMD2
RETREG3
RHBDD2
RHEB
SCN3B
SHANK3
SLC10A1
SLC10A6
SLC35A5
SLC35B1
SLC71A2
SMO
TERF1
TMEM14B
TMEM254
TMEM31
TMEM43
TMEM45B
TMEM80
TMX1
VHL
ZFPL1
61 interacting genes:
AKT1
AKT1S1
AMBRA1
BCL2L1
C7orf25
CDC37
CFP
CLIP1
DCP2
EIF3F
EIF4EBP1
EIF4EBP2
EP300
ESR1
FBXO8
FKBP1A
FKBP8
FLNA
GPHN
GSK3B
HRAS
IRS1
MAF1
MAPKAP1
MLST8
NRAS
PA2G4
PCNA
PDPK1
PLD2
PLEKHM1
PPP2R2A
PREX1
PRKAA1
PRKCA
PRKN
PRR5L
RAB1A
RHEB
RHEBL1
RICTOR
RPS6
RPS6KA1
RPS6KA3
RPS6KB1
RPS6KB2
RPTOR
RRAGB
SEPTIN2
SKP2
STAT3
SUMO1
TELO2
TERT
TRAF6
UBQLN1
ULK1
UVRAG
WIPI2
YWHAQ
ZNRF2
Entrez ID
23770
2475
HPRD ID
05327
03134
Ensembl ID
ENSG00000105701
ENSG00000198793
Uniprot IDs
B2R8G6
Q14318
A0A8V8TQ52
P42345
PDB IDs
2AWG
2D9F
2F2D
2MF9
3EY6
5MGX
1AUE
1FAP
1NSG
2FAP
2GAQ
2NPU
2RSE
3FAP
3JBZ
4DRH
4DRI
4DRJ
4FAP
4JSN
4JSP
4JSV
4JSX
4JT5
4JT6
5FLC
5GPG
5H64
5WBH
5WBU
5WBY
5ZCS
6BCU
6BCX
6M4U
6M4W
6SB0
6SB2
6ZWM
6ZWO
7EPD
7OWG
7PE7
7PE8
7PE9
7PEA
7PEB
7PEC
7TZO
7UXC
7UXH
8ER6
8ER7
8ERA
8PPZ
8RCH
8RCK
8RCN
9F44
9F45
Enriched GO Terms of Interacting Partners
?
Membrane
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum
Regulation Of Cellular Localization
Mitochondrial Membrane
Negative Regulation Of Catabolic Process
Regulation Of Protein Localization
Bcl-2 Family Protein Complex
Protein Binding
Transmembrane Transport
Negative Regulation Of Autophagy
Dendritic Cell Apoptotic Process
Ascorbate Homeostasis
Intracellular Signal Transduction
Regulation Of Membrane Potential
Transmembrane Monodehydroascorbate Reductase Activity
Striated Muscle Cell Development
Skeletal Muscle Fiber Development
Bile Acid:sodium Symporter Activity
Positive Regulation Of Growth
Regulation Of Protein Catabolic Process
BH3 Domain Binding
Myotube Cell Development
Regulation Of Establishment Of Protein Localization
Muscle Cell Development
Negative Regulation Of Calcium Ion Transmembrane Transport
Intracellular Signaling Cassette
Regulation Of TORC1 Signaling
Channel Activity
ERBB2-EGFR Signaling Pathway
Cell Morphogenesis
Autophagy
Negative Regulation Of Dendritic Cell Apoptotic Process
Positive Regulation Of Striated Muscle Cell Differentiation
Oligodendrocyte Differentiation
Monoatomic Ion Transport
Regulation Of Myotube Differentiation
Positive Regulation Of Establishment Of Protein Localization
Negative Regulation Of Translational Initiation
Pyrimidine Nucleotide-sugar Transmembrane Transport
Regulation Of Growth
Positive Regulation Of Translational Initiation
Mononuclear Cell Proliferation
Nucleotide-sugar Transmembrane Transport
Negative Regulation Of Calcium Ion Transport
Identical Protein Binding
Proteasomal Protein Catabolic Process
Proteasome Regulatory Particle, Base Subcomplex
Proteasome Regulatory Particle
Ciliary Membrane
TOR Signaling
Intracellular Signal Transduction
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
TORC1 Signaling
Regulation Of Autophagy
Intracellular Signaling Cassette
Regulation Of TOR Signaling
TORC2 Signaling
Autophagosome Assembly
Autophagosome Organization
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Cytosol
Regulation Of Apoptotic Process
Cellular Response To Nutrient Levels
Regulation Of Programmed Cell Death
Regulation Of Protein Metabolic Process
Regulation Of Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Signal Transduction
Positive Regulation Of Catabolic Process
Positive Regulation Of TOR Signaling
Regulation Of Signaling
Regulation Of Cell Communication
Vacuole Organization
Cytoplasm
Post-transcriptional Regulation Of Gene Expression
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Autophagy
Regulation Of Translational Initiation
Negative Regulation Of Translational Initiation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Translation
Positive Regulation Of Translational Initiation
Insulin Receptor Signaling Pathway
Regulation Of Biological Quality
Protein Kinase Binding
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of TORC1 Signaling
Response To Nutrient Levels
Organelle Organization
Positive Regulation Of TORC1 Signaling
Positive Regulation Of Cell Population Proliferation
Signal Transduction
Positive Regulation Of Cell Growth
Regulation Of Cellular Component Organization
Negative Regulation Of Catabolic Process
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?