RFC2 and RFC1

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (biochemical, biochemical)
HPRD (in vivo)

		RFC2	RFC1
Gene Name		replication factor C (activator 1) 2, 40kDa	replication factor C (activator 1) 1, 145kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Golgi Apparatus	Nucleus Nucleoplasm DNA Replication Factor C Complex Nucleolus Golgi Apparatus Cell Junction Extracellular Vesicular Exosome
	Molecular Function	DNA Clamp Loader Activity Protein Binding ATP Binding	DNA Binding DNA Clamp Loader Activity Double-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity Protein Domain Specific Binding Sequence-specific DNA Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Transcription, DNA-templated Telomere Maintenance Via Telomerase Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Catalytic Activity Positive Regulation Of Transcription, DNA-templated
Pathways		Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER) Activation of ATR in response to replication stress Cell Cycle Checkpoints	Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: BRD4 PCNA PRKAR1A RAD17 RAD18 RFC1 RFC4 RFC5	19 interactors: BRCA1 BRD4 CASP3 CCND1 CDK4 CEBPA CSNK2B HDAC1 MYOC PCNA RELA RFC2 RFC3 RFC4 SMC1A SSBP3 TCEAL1 YWHAQ ZSCAN1
Entrez ID		5982	5981
HPRD ID		02675	00024
Ensembl ID		ENSG00000049541	ENSG00000035928
Uniprot IDs		P35250 Q75MT5	P35251
PDB IDs			2EBU 2K6G 2K7F
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus DNA Repair Telomere Maintenance DNA Replication Cell Cycle Nucleotide-excision Repair Mitotic Cell Cycle DNA-dependent DNA Replication Cellular Response To Stress Cell Cycle Process DNA Metabolic Process Response To Stress DNA Recombination Chromosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Homeostatic Process Cellular Response To Stimulus Cellular Homeostasis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process Response To Stimulus Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of DNA Metabolic Process Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Leading Strand Elongation Regulation Of DNA Replication Cellular Metabolic Process Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Damage Checkpoint Histone H3-K14 Acetylation Biosynthetic Process Cell Proliferation Regulation Of Nitrogen Compound Metabolic Process	Mitotic Cell Cycle Nucleotide-excision Repair, DNA Gap Filling Cell Cycle Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Response To DNA Damage Stimulus Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Chromosome Organization Transcription-coupled Nucleotide-excision Repair Nucleobase-containing Compound Metabolic Process Cell Cycle Process Negative Regulation Of Cell Cycle Cellular Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Telomere Maintenance Nitrogen Compound Metabolic Process Cellular Response To Stimulus Organelle Organization Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Nucleotide-excision Repair DNA Recombination Anatomical Structure Development Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA-dependent DNA Replication DNA Replication Regulation Of Metabolic Process Developmental Process Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process DNA Repair Multicellular Organismal Development Response To Organic Substance Regulation Of G2/M Transition Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Biosynthetic Process DNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus
Tagcloud ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc3 rfc4 rfc5	b12 bnip3 brac1 brca1 c1420t c1561t cnnd1 cpg cshmt dependency g80a gcpii homocysteine hyperhomocysteinemia hypermethylation hypomethioninemia hypothesize influencing inverse inversely island loci methionine methylation positively rarbeta1 rassf1 remethylation suppressors
Tagcloud (Difference) ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc3 rfc4 rfc5	b12 bnip3 brac1 brca1 c1420t c1561t cnnd1 cpg cshmt dependency g80a gcpii homocysteine hyperhomocysteinemia hypermethylation hypomethioninemia hypothesize influencing inverse inversely island loci methionine methylation positively rarbeta1 rassf1 remethylation suppressors
Tagcloud (Intersection) ?