RFC2 and PRKAR1A

Number of citations of the paper that reports this interaction (PubMedID 15096576)
37

Data Source:
HPRD (in vivo)

		RFC2	PRKAR1A
Description		replication factor C subunit 2	protein kinase cAMP-dependent type I regulatory subunit alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Ctf18 RFC-like Complex	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Plasma Membrane Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Synapse Ciliary Base Glutamatergic Synapse Sperm Head-tail Coupling Apparatus
	Molecular Function	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	DNA Replication DNA-templated DNA Replication DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity	Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Negative Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases			Pigmented micronodular adrenocortical disease (PPNAD)
GWAS			Body size at age 10 ( 32376654) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		14 interacting genes: CEBPA HGS KLHL20 PCNA PRKAR1A PSMA1 RAD17 RAD18 RFC1 RFC4 RFC5 SUMO2 YOD1 ZIC1	55 interacting genes: AKAP1 AKAP10 AKAP11 AKAP19 AKAP4 AKAP5 AKAP7 AKT1 ARFGEF2 BAHD1 BTG3 CAPN11 CBS CCNE1 CDK2 CDK4 CSTPP1 DSCR4 DSCR9 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAP1A MAP1B MAPK6 MYO7A NELL2 OGT PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PSMG1 PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SNCA SPART TAB1 WDCP WNK1 YWHAZ ZBED1
Entrez ID		5982	5573
HPRD ID		02675	01786
Ensembl ID		ENSG00000049541	ENSG00000108946
Uniprot IDs		A0A087WVY3 P35250 Q75MT5	B2R5T5 P10644
PDB IDs		6VVO 7Z6H 8UI7 8UI8 8UI9 8UII 8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ	5KJX 5KJY 5KJZ
Enriched GO Terms of Interacting Partners?		DNA Clamp Loader Activity DNA Replication Factor C Complex Positive Regulation Of DNA-directed DNA Polymerase Activity Elg1 RFC-like Complex DNA Repair Macromolecule Metabolic Process DNA Replication Positive Regulation Of DNA Biosynthetic Process DNA-templated DNA Replication Ctf18 RFC-like Complex Cellular Response To Stress DNA Metabolic Process DNA Damage Response Protein Domain Specific Binding Regulation Of DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Ubiquitin Protein Ligase Binding Single-stranded DNA Helicase Activity DNA Strand Elongation Chromosome Ubiquitin-like Protein Ligase Binding Replication Fork Nucleoplasm Regulation Of Primary Metabolic Process Postreplication Repair Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process PCNA Complex Replisome Rad17 RFC-like Complex Type II Interferon Binding Rad6-Rad18 Complex Animal Organ Regeneration DNA Binding Regulation Of Catalytic Activity Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Vitamin B2 C/EBP Complex Damaged DNA Binding PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Positive Regulation Of DNA Metabolic Process Purine-specific Mismatch Base Pair DNA N-glycosylase Activity	Protein Kinase A Regulatory Subunit Binding CAMP-dependent Protein Kinase Complex Protein Kinase A Binding Protein Phosphorylation Cytosol Phosphorylation Protein-containing Complex Ubiquitin Protein Ligase Binding Cytoplasm Peptidyl-serine Phosphorylation Regulation Of Protein Localization To Cell Periphery Protein Serine Kinase Activity Intracellular Signal Transduction Regulation Of Biological Quality Signal Transduction Kinase Activity Protein Kinase Activity Cyclin E1-CDK2 Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Serine/threonine Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation TORC1 Signaling Regulation Of Lymphocyte Migration Intracellular Signaling Cassette Postsynapse Cellular Response To Oxygen-containing Compound Protein Kinase Binding Intracellular Protein Localization Protein Domain Specific Binding Cell Surface Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Localization To Cell Periphery ERBB Signaling Pathway Regulation Of Anaphase-promoting Complex-dependent Catabolic Process CAMP-dependent Protein Kinase Activity Establishment Of Protein Localization TOR Signaling Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of T Cell Migration Odontoblast Differentiation Regulation Of Protein Kinase A Signaling Organelle Organization Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Membrane Enzyme Binding
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