CLIC4 and TPRN

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		CLIC4	TPRN
Description		chloride intracellular channel 4	taperin
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Cytoskeleton Plasma Membrane Microvillus Cell-cell Junction Cell Surface Actin Cytoskeleton Microtubule Cytoskeleton Membrane Nuclear Matrix Midbody Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Monoatomic Ion Channel Complex Chloride Channel Complex Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Microvillus Stereocilium Cell Projection Stereocilium Base
	Molecular Function	Chloride Channel Activity Protein Binding Oxidoreductase Activity	Actin Binding Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Phosphatase Binding Protein Phosphatase Binding
	Biological Process	Angiogenesis Endothelial Cell Morphogenesis Monoatomic Ion Transport Chloride Transport Vacuolar Acidification Fertilization Cell Differentiation Keratinocyte Differentiation Negative Regulation Of Cell Migration Monoatomic Ion Transmembrane Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Multicellular Organism Growth Branching Morphogenesis Of An Epithelial Tube Regulation Of Cytoskeleton Organization Retina Vasculature Morphogenesis In Camera-type Eye Cellular Response To Calcium Ion Chloride Transmembrane Transport	Sensory Perception Of Sound Auditory Receptor Cell Stereocilium Organization Stereocilium Maintenance
Pathways			Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549) Height ( 20881960) Male-pattern baldness ( 28196072) Systolic blood pressure ( 29208002)	Obesity-related traits ( 23251661)
Interacting Genes		8 interacting genes: ACTB CLIC6 DNM1 ERCC6 HSP90AB1 REL TPRN YWHAZ	9 interacting genes: CLIC1 CLIC2 CLIC4 CLIC5 EPS8 MYO15B PPP1CA PPP1CC WHRN
Entrez ID		25932	286262
HPRD ID		05943	12977
Ensembl ID		ENSG00000169504	ENSG00000176058
Uniprot IDs		Q6FIC5 Q9Y696	Q4KMQ1
PDB IDs		2AHE 2D2Z 3OQS	6Y9Q
Enriched GO Terms of Interacting Partners?		Nitric-oxide Synthase Regulator Activity Protein Kinase Binding Positive Regulation Of Double-strand Break Repair Positive Regulation Of DNA Recombination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination ATP Hydrolysis Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Tau Protein Binding Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Vesicle Scission Clathrin Coat Assembly Involved In Endocytosis Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein HSP90-CDC37 Chaperone Complex Melanosome Synaptic Target Recognition Protein Phosphatase Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Extracellular Exosome Blood Microparticle Transporter Regulator Activity D2 Dopamine Receptor Binding Stereocilium Maintenance Regulation Of DNA Recombination Positive Regulation Of DNA Repair Regulation Of Transepithelial Transport Chromaffin Granule NF-kappaB Complex Stereocilium Base Regulation Of Double-strand Break Repair Protein Localization To Adherens Junction Dense Body Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Golgi Reassembly Nucleoplasm Morphogenesis Of A Polarized Epithelium Response To Superoxide Receptor Ligand Inhibitor Activity Telomerase Holoenzyme Complex Assembly Phosphoserine Residue Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Vesicle DNA Protection Transcription Elongation By RNA Polymerase I Response To Oxygen Radical ATP-dependent Protein Binding B-WICH Complex Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Chloride Channel Complex Chloride Channel Activity Chloride Transmembrane Transport Chloride Transport Inorganic Anion Transmembrane Transport Monoatomic Ion Channel Complex Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Stereocilium PTW/PP1 Phosphatase Complex Stereocilium Bundle Stereocilium Tip Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock Oxidoreductase Activity Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Brush Border Glycogen Metabolic Process Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatase Activity Monoatomic Ion Transport Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Cerebellar Purkinje Cell Layer Formation Paranodal Junction Maintenance Regulation Of Circadian Rhythm Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Stereocilia Ankle Link USH2 Complex Extracellular Exosome Plasma Membrane Transmembrane Transport Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Termination Of DNA-templated Transcription Dephosphorylation Positive Regulation Of Termination Of RNA Polymerase II Transcription Branching Morphogenesis Of An Epithelial Tube Circadian Rhythm Phosphoprotein Phosphatase Activity Growth Cone Glutamatergic Synapse Dendritic Spine Stereocilia Ankle Link Complex
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