MIR25 and TRIM56

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR25	TRIM56
Description		microRNA 25	tripartite motif containing 56
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	MRNA Base-pairing Post-transcriptional Repressor Activity	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Cardiac Muscle Tissue Growth Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Immune System Process Protein Monoubiquitination Protein Ubiquitination Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Response To Type I Interferon Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K63-linked Ubiquitination CGAS/STING Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways			Regulation of innate immune responses to cytosolic DNA
Drugs
Diseases
GWAS			Alzheimer's disease ( 30636644) Nonunion in individuals with fractures ( 30680360)
Interacting Genes		100 interacting genes: AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CDC5L CELF1 CPSF6 CPSF7 DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EIF2AK2 ELAC1 EPRS1 ESRP1 FAM98A FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PATL1 PDCD11 PGAM5 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA PURB QARS1 RARS1 RBFOX2 RBM14 RBM17 RBM4 RBM45 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRIM25 TRIM56 TRIM71 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3	5 interacting genes: MIR200C MIR25 MIR34B UBE2H WEE2-AS1
Entrez ID		407014	81844
HPRD ID			10284
Ensembl ID		ENSG00000207547	ENSG00000169871
Uniprot IDs			Q9BRZ2
PDB IDs			5JW7
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process RNA Splicing MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Binding Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome Nucleus RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Nucleoplasm Post-transcriptional Regulation Of Gene Expression Aminoacyl-tRNA Synthetase Multienzyme Complex Spliceosomal Complex Ribonucleoprotein Complex Catalytic Step 2 Spliceosome Cytoplasmic Stress Granule Regulation Of Translation MiRNA Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Regulation Of MRNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Metabolic Process TRNA Aminoacylation Ligase Activity MRNA Stabilization Negative Regulation Of Metabolic Process P-body	MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Muscle System Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Cardiac Muscle Hypertrophy RISC Complex MRNA Destabilization RNA Destabilization Regulation Of System Process Post-transcriptional Regulation Of Gene Expression Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Transmembrane Transport MRNA 3'-UTR Binding Negative Regulation Of Interleukin-33 Production Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Mesodermal Cell Differentiation Pre-mRNA 5'-splice Site Binding Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Calcium Ion Import Across Plasma Membrane MRNA 5'-splice Site Recognition Regulation Of Response To Drug Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of MRNA Metabolic Process Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Endothelial Cell Differentiation Regulation Of Connective Tissue Replacement Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Multicellular Organismal Development U1 SnRNP Negative Regulation Of Transport Positive Regulation Of Tissue Remodeling Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Cardiac Muscle Tissue Growth Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Ubiquitin Conjugating Enzyme Activity MRNA Splice Site Recognition
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