ENSA and ARIH2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ENSA	ARIH2
Description		endosulfine alpha	ariadne RBR E3 ubiquitin protein ligase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Phosphatase Inhibitor Activity Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Phosphatase Inhibitor Activity Potassium Channel Inhibitor Activity Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Response To Nutrient Regulation Of Insulin Secretion Cell Division	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Developmental Cell Growth Defense Response To Virus Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		MASTL Facilitates Mitotic Progression MASTL Facilitates Mitotic Progression	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Chronotype ( 30696823) Coffee consumption ( 31959922) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082) Mean corpuscular volume ( 32888494) Monocyte count ( 29403010 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Morning person ( 30696823) Neutrophil percentage of granulocytes ( 27863252) Non-albumin protein levels ( 29403010) Pericardial adipose tissue adjusted for height and weight ( 27918534) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Sum eosinophil basophil counts ( 27863252) Urate levels ( 31578528)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)
Interacting Genes		11 interacting genes: ABCC8 ACD ARIH2 DNMT1 ENO2 KCTD15 POT1 PSEN1 RAP2A SNCA SRPK2	57 interacting genes: APOBEC3C APOBEC3F APOBEC3G ARAP1 BUB1 CBR3 CCDC33 CEP126 CKB CRX DCUN1D1 DISC1 DLST DSCAM EEF1A1 EEF1G EIF4E2 EML4 ENSA IL4R KAT5 KCNQ2 MEOX2 NEDD8 OGT PAX6 PHF7 PPP2R1A PTN RBX1 REL RHEB RNF7 RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 USP2-AS1 UTP14A WDR91
Entrez ID		2029	10425
HPRD ID		11927	09286
Ensembl ID		ENSG00000143420	ENSG00000177479
Uniprot IDs		O43768	O95376 Q53ET9 Q6IBL8
PDB IDs			7OD1 7ONI
Enriched GO Terms of Interacting Partners?		Magnesium Ion Binding Synaptic Membrane Telomerase Inhibitor Activity Shelterin Complex Telomere Assembly Establishment Of Protein Localization To Telomere Nuclear Telomere Cap Complex Telomere Capping Positive Regulation Of Receptor Recycling Positive Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization Growth Cone Negative Regulation Of Nervous System Development Negative Regulation Of Neurogenesis Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Regulation Of Receptor Recycling RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cell Cortex L-glutamate Import Regulation Of Protein Localization Nuclear Outer Membrane Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Neurotransmitter Secretion Regulation Of Establishment Of Protein Localization Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cellular Component Organization Acidic Amino Acid Transport Regulation Of Neuron Apoptotic Process Organelle Organization Segmentation Negative Regulation Of Core Promoter Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Uterine Smooth Muscle Relaxation Negative Regulation Of Neuroblast Migration Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Cell Development Regulation Of Dendrite Morphogenesis	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Protein Monoubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Cytosol Transferase Activity Macromolecule Metabolic Process Protein Modification Process Macromolecule Catabolic Process Protein Metabolic Process Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Proteolysis TOR Signaling Catabolic Process Protein Neddylation ISG15-protein Conjugation DNA Cytosine Deamination TORC1 Signaling Nucleoplasm Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Cytidine To Uridine Editing Cytidine Deaminase Activity DNA Deamination Negative Regulation Of Neuroblast Proliferation Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Neuroblast Proliferation Regulation Of Neural Precursor Cell Proliferation Regulation Of Post-translational Protein Modification Base Conversion Or Substitution Editing Negative Regulation Of Gene Expression Regulation Of TORC1 Signaling Cellular Response To Nutrient Levels Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination UBC13-MMS2 Complex Regulation Of Protein Metabolic Process Ubiquitin-like Protein Transferase Activity Ubiquitin Ligase Complex
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