RALB and CXCR4

		RALB	CXCR4
Description		RAS like proto-oncogene B	C-X-C motif chemokine receptor 4
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GO Annotations	Cellular Component	Plasma Membrane Membrane Midbody Extracellular Exosome	Cytoplasm Lysosome Endosome Early Endosome Late Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Extracellular Exosome Anchoring Junction
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Ubiquitin Protein Ligase Binding ATPase Binding	Virus Receptor Activity Actin Binding G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Cytokine Binding C-C Chemokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding C-X-C Motif Chemokine 12 Receptor Activity Ubiquitin Binding
	Biological Process	Regulation Of Exocyst Assembly Apoptotic Process Signal Transduction Ras Protein Signal Transduction Receptor Internalization Positive Regulation Of Innate Immune Response Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Division Regulation Of Exocyst Localization Positive Regulation Of Autophagosome Assembly	Response To Hypoxia Dendritic Cell Chemotaxis Apoptotic Process Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Brain Development Response To Virus Cell Migration Calcium-mediated Signaling Neurogenesis Regulation Of Cell Adhesion Regulation Of Cell Migration Positive Regulation Of Cell Migration CXCL12-activated CXCR4 Signaling Pathway Myelin Maintenance Symbiont Entry Into Host Cell Positive Regulation Of Oligodendrocyte Differentiation Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vasculature Development Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways		p38MAPK events	Binding and entry of HIV virion Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events Formation of definitive endoderm Specification of primordial germ cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs			Baclofen Framycetin AMD-070 Plerixafor Ulocuplumab Ibalizumab MSX-122
Diseases			Chemokine receptor defect, including the following disease: WHIM syndrome
GWAS		Breast size ( 27182965) Intraocular pressure ( 29617998) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arthritis (juvenile idiopathic) ( 27005825) Attention deficit hyperactivity disorder ( 32595297) Body mass index ( 26426971) Colorectal cancer ( 29228715) Estimated glomerular filtration rate ( 31152163) Lung function (low FEV1 vs high FEV1) ( 26423011) Monocyte count ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 19525953 31604244) Non-albumin protein levels ( 29403010) Smoking status (ever vs never smokers) ( 30643258) Telomere length ( 20421499) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: CALM1 INCA1 PLCD1 RALBP1 REPS1 REPS2 RGL4	34 interacting genes: ARRB2 ATP13A2 B2M CCR5 CD4 CTSG CXCL12 DPP4 DUXAP9 ELANE GNA13 GNAI1 GRK3 HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC RNF113A SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1
Entrez ID		5899	7852
HPRD ID		01550	01217
Ensembl ID		ENSG00000144118	ENSG00000121966
Uniprot IDs		P11234	A0A0U3FJG0 A0A0U3GXA9 A0A8Q3WLL1 P61073
PDB IDs		2KE5 2KWI 6ZQT 6ZRN	2K03 2K04 2K05 2N55 3ODU 3OE0 3OE6 3OE8 3OE9 4RWS 8GP3 8I0Q 8K3Z 8U4N 8U4O 8U4P 8U4Q 8U4R 8U4S 8U4T 8YU7 8ZPL 8ZPM 8ZPN
Enriched GO Terms of Interacting Partners?		Endocytosis Intracellular Signaling Cassette Import Into Cell Calcium Ion Binding Signal Transduction Intracellular Signal Transduction Plasma Membrane C-X-C Motif Chemokine 12 Receptor Activity Doxorubicin Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Vesicle-mediated Transport Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Calcium-mediated Signaling Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Autophagosome Membrane Docking Spindle Pole Phosphatidylinositol Phospholipase C Activity Anion Binding Phospholipase C/protein Kinase C Signal Transduction CXCL12-activated CXCR4 Signaling Pathway Myosin Light Chain Binding Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway C-X-C Chemokine Receptor CXCR4 Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway C-X-C Chemokine Receptor Activity ABC-type Glutathione S-conjugate Transporter Activity Protein-macromolecule Adaptor Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity	Regulation Of Cell-cell Adhesion Cytokine-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via STAT Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Growth Hormone Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Adhesion Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Activation Regulation Of Defense Response Positive Regulation Of T Cell Activation Response To Stress Defense Response Positive Regulation Of Immune System Process Interleukin-9-mediated Signaling Pathway Negative Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Response To Other Organism Cell Activation Immune System Process Negative Regulation Of Leukocyte Cell-cell Adhesion Response To External Biotic Stimulus Regulation Of Cytokine Production Interleukin-15-mediated Signaling Pathway Leukocyte Activation Positive Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Cell Migration Regulation Of Leukocyte Proliferation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Population Proliferation Negative Regulation Of Leukocyte Activation Positive Regulation Of Cell Activation Leukocyte Mediated Cytotoxicity T Cell Activation Negative Regulation Of T Cell Activation Positive Regulation Of Immune Response Regulation Of Developmental Process Interleukin-6-mediated Signaling Pathway Regulation Of Multicellular Organismal Process
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