PZP and TGFB2

Number of citations of the paper that reports this interaction (PMID 7513640)
5

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PZP	TGFB2
Gene Name		pregnancy-zone protein	transforming growth factor, beta 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Endosome Axon Extracellular Matrix Platelet Alpha Granule Lumen Neuronal Cell Body
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Beta-amyloid Binding Receptor Signaling Protein Serine/threonine Kinase Activity Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Type III Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Female Pregnancy Negative Regulation Of Endopeptidase Activity	Cell Morphogenesis Cartilage Condensation Angiogenesis Eye Development Response To Hypoxia Epithelial To Mesenchymal Transition Hair Follicle Development Blood Vessel Remodeling Platelet Degranulation Heart Morphogenesis Heart Valve Morphogenesis Protein Phosphorylation Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Import Into Nucleus Cell-cell Signaling Axon Guidance Salivary Gland Morphogenesis Heart Development Blood Coagulation Cell Death Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Glial Cell Migration Response To Wounding Embryo Development Cardioblast Differentiation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Growth Cell Migration Signal Transduction By Phosphorylation Hemopoiesis Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Neutrophil Chemotaxis Hair Follicle Morphogenesis Activation Of Protein Kinase Activity Response To Progesterone Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Cell Adhesion Mediated By Integrin Wound Healing Dopamine Biosynthetic Process Odontogenesis Response To Drug Catagen Uterine Wall Breakdown Positive Regulation Of Neuron Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Ossification Positive Regulation Of Cell Cycle Positive Regulation Of Heart Contraction Somatic Stem Cell Division Embryonic Digestive Tract Development Neuron Fate Commitment Neuron Development Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Immune Response Positive Regulation Of Immune Response Positive Regulation Of Cell Division Positive Regulation Of Catagen Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Face Morphogenesis Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Negative Regulation Of Cartilage Development Positive Regulation Of Activation-induced Cell Death Of T Cells Extrinsic Apoptotic Signaling Pathway Regulation Of Extracellular Matrix Organization Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Molecules associated with elastic fibres Elastic fibre formation Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Non-alcoholic fatty liver disease histology (AST) ( 20708005) Obesity-related traits ( 23251661)	Height ( 20881960) Pulmonary function ( 21946350)
Protein-Protein Interactions		6 interactors: CPB2 KLK3 MMP2 MMP9 TGFB1 TGFB2	16 interactors: APP BMP2 CTGF DAXX DCN ENG FMOD LTBP3 PZP TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBR3 VASN VTN
Entrez ID		5858	7042
HPRD ID		07178	01828
Ensembl ID		ENSG00000126838	ENSG00000092969
Uniprot IDs			P61812
PDB IDs			1TFG 2TGI
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Face Morphogenesis Regulation Of Extracellular Matrix Organization Head Morphogenesis Face Development Negative Regulation Of Macrophage Cytokine Production Body Morphogenesis Positive Regulation Of Epithelial Cell Migration Endoderm Development Extracellular Matrix Disassembly Blood Coagulation SMAD Protein Import Into Nucleus Hemostasis Negative Regulation Of Epithelial Cell Proliferation Pathway-restricted SMAD Protein Phosphorylation Regulation Of Fibrinolysis Regulation Of Epithelial Cell Migration Skeletal System Development Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cell Morphogenesis Involved In Differentiation Female Pregnancy Fibrinolysis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Skeletal System Morphogenesis Ossification Regulation Of Epithelial Cell Proliferation Endodermal Cell Differentiation Response To Hypoxia Positive Regulation Of Secretion Positive Regulation Of Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Salivary Gland Morphogenesis Positive Regulation Of Cell Motility Cell Morphogenesis Salivary Gland Development Positive Regulation Of Cellular Component Movement Response To Abiotic Stimulus Positive Regulation Of Locomotion Response To Progesterone Positive Regulation Of Stem Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Blood Coagulation Endoderm Formation SMAD Protein Signal Transduction Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition	Extracellular Matrix Organization Extracellular Structure Organization Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Epithelial To Mesenchymal Transition Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Organ Morphogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Skeletal System Development Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Anatomical Structure Morphogenesis Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Regulation Of Cartilage Development Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Phosphorus Metabolic Process Bone Development Response To Wounding Regulation Of Signal Transduction Regulation Of Collagen Metabolic Process Regulation Of Cell Differentiation Regulation Of Protein Metabolic Process Skeletal System Morphogenesis Response To Lipid Response To Hypoxia Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Cell Growth Aging
Tagcloud ?		alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld ncan obtaining parvb patatin pnpla3 rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride	beta2 betageo cko conditional congenital crossing die dietz dysregulation eiiacre fetuses flox flper galactosidase genesis harboring lacz loeys multifunctional neuromuscular ocular organs osteoarthritis perinatal perinatally precluding resembled tagged
Tagcloud (Difference) ?		alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld ncan obtaining parvb patatin pnpla3 rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride	beta2 betageo cko conditional congenital crossing die dietz dysregulation eiiacre fetuses flox flper galactosidase genesis harboring lacz loeys multifunctional neuromuscular ocular organs osteoarthritis perinatal perinatally precluding resembled tagged
Tagcloud (Intersection) ?