PZP

Description		PZP alpha-2-macroglobulin like
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Female Pregnancy
Pathways
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Depression in smokers ( 30219690) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Low density lipoprotein cholesterol levels ( 32154731) Myopia ( 27182965) Non-alcoholic fatty liver disease histology (AST) ( 20708005) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		6 interacting genes: CPB2 KLK3 MMP2 MMP9 TGFB1 TGFB2
Entrez ID		5858
HPRD ID		07178
Ensembl ID		ENSG00000126838
Uniprot IDs		P20742
PDB IDs
Enriched GO Terms of Interacting Partners?		Face Morphogenesis Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Type III Transforming Growth Factor Beta Receptor Binding Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endopeptidase Activity Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Proliferation Extracellular Region Cellular Response To UV-A Type II Transforming Growth Factor Beta Receptor Binding Salivary Gland Morphogenesis Extracellular Matrix Peptidase Activity Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Multicellular Organismal Process Proteolysis Metallopeptidase Activity Response To UV-A Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Cardiocyte Differentiation Serine-type Endopeptidase Activity Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cellular Response To Radiation Positive Regulation Of Locomotion Regulation Of Multicellular Organismal Process Regulation Of Extracellular Matrix Disassembly Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Response To Wounding Positive Regulation Of Extracellular Matrix Organization Gland Morphogenesis Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Response To Progesterone Negative Regulation Of Cytokine Production Involved In Immune Response Endodermal Cell Differentiation Response To Lipid Regulation Of Macrophage Cytokine Production Heart Development Collagen Catabolic Process Ovulation Cycle Process Positive Regulation Of SMAD Protein Signal Transduction Response To Fluid Shear Stress Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
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