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DMRT3 and PSMA3
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
DMRT3
PSMA3
Gene Name
doublesex and mab-3 related transcription factor 3
proteasome (prosome, macropain) subunit, alpha type, 3
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Extracellular Vesicular Exosome
Molecular Function
Core Promoter Proximal Region Sequence-specific DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
Threonine-type Endopeptidase Activity
Protein Binding
Biological Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Sex Differentiation
Adult Walking Behavior
Transmission Of Nerve Impulse
Ventral Spinal Cord Interneuron Specification
Regulation Of Odontogenesis Of Dentin-containing Tooth
Male Sex Differentiation
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Small Molecule Metabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Diseases
GWAS
Major depressive disorder (
23377640
)
Protein-Protein Interactions
26 interactors:
CCNDBP1
INCA1
KHDRBS3
KRT31
KRT40
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP5-9
MDFI
MGAT5B
MID2
MTUS2
NOTCH2NL
PLSCR1
PSMA3
RBPMS
REL
SAT1
TCF4
TRAF1
TRIM23
TRIM27
TRIP6
UBASH3B
114 interactors:
APLN
ATN1
ATP6V0C
AURKB
BTN2A2
BTRC
C14orf159
C1orf105
C1QTNF9B-AS1
C9orf106
CCDC69
CCL28
CDK6
CDKN1A
CRB3
CRYAB
CSNK2A1
CST2
CTAGE5
CTBP1-AS2
CYBA
DDX5
DMC1
DMRT3
DVL1
EGR1
FAM103A1
FAM171A2
FAM218A
FBXL18
FBXO7
FRAT1
GATA2
GATA3
GFI1B
GORASP2
HHEX
HNRNPA2B1
IKBKG
IQCE
KIF1A
KIRREL2
KIRREL3-AS3
KRAS
KRTAP19-5
KRTAP26-1
KRTAP8-1
LASP1
LBP
LETM1
LINC00908
LOC149950
LPHN1
MDM2
MUM1
NEU4
NPBWR2
NPPB
NUMBL
OSR2
PATL1
PLK1
PML
POMP
PRNP
PRR13
PRR3
PRRC2A
PSMA1
PSMA2
PSMA4
PSMA6
PSMA7
PSMB10
PSMB4
PSMB5
PSMD1
PTPN23
PWWP2B
RAB3IL1
RAD54L2
RBFOX2
RBM42
RERE
RFT1
RTP5
RUSC1-AS1
SERF2
SF1
SH3KBP1
SLAIN1
SLC22A23
SLMO1
SNRPB
SNRPC
SNRPF
SPATA8
SRPK2
STUB1
STX11
STX1A
STX4
STX6
TBC1D16
TBX6
TCF7L2
TINCR
TRIB3
URB1-AS1
VPS37C
XRN2
YPEL3
ZNF366
ZNF385C
Entrez ID
58524
5684
HPRD ID
16827
01463
Ensembl ID
ENSG00000064218
ENSG00000100567
Uniprot IDs
Q9NQL9
P25788
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Transport
Regulation Of Signal Transduction
Regulation Of Nucleocytoplasmic Transport
Negative Regulation Of Viral Process
Regulation Of Intracellular Protein Transport
Regulation Of Signaling
Negative Regulation Of Viral Release From Host Cell
Negative Regulation Of Transferase Activity
Positive Regulation Of Nucleocytoplasmic Transport
Regulation Of Protein Transport
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Cellular Localization
Negative Regulation Of Viral Transcription
Negative Regulation Of Cellular Metabolic Process
Regulation Of Viral Release From Host Cell
Regulation Of Establishment Of Protein Localization
Regulation Of Protein Metabolic Process
Regulation Of Viral Process
Positive Regulation Of Intracellular Protein Transport
Regulation Of Protein Import Into Nucleus
Regulation Of Protein Localization
Regulation Of Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Wnt Signaling Pathway
Regulation Of Protein Localization To Nucleus
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Protein Kinase Activity
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Kinase Activity
Positive Regulation Of Intracellular Transport
Regulation Of Transcription, DNA-templated
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Protein Ubiquitination
Regulation Of Cellular Process
Regulation Of RNA Metabolic Process
Protein Modification By Small Protein Conjugation
Regulation Of Protein Phosphorylation
Regulation Of Viral Transcription
Spermidine Acetylation
Negative Regulation Of Interleukin-2 Secretion
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Transcription, DNA-templated
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Ligase Activity
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle
Regulation Of Ubiquitin-protein Transferase Activity
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic G1 DNA Damage Checkpoint
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Cell Cycle Arrest
DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Signal Transduction By P53 Class Mediator
Positive Regulation Of Cellular Protein Catabolic Process
Positive Regulation Of Wnt Signaling Pathway
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Signal Transduction In Response To DNA Damage
Mitotic Cell Cycle Checkpoint
Regulation Of Cell Cycle Arrest
Mitotic DNA Damage Checkpoint
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Mitotic DNA Integrity Checkpoint
Negative Regulation Of Mitotic Cell Cycle
Cell Cycle Checkpoint
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Transferase Activity
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
DNA Damage Checkpoint
Regulation Of Wnt Signaling Pathway
Regulation Of Protein Ubiquitination
Positive Regulation Of Cell Cycle Process
Negative Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cell Cycle
Regulation Of Cell Cycle
Positive Regulation Of Proteolysis
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Protein Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Tagcloud
?
20s
alpha5
alpha6
alpha7
alphal
apparatus
cations
dephosphorylation
electrophoretic
endonuclease
endoribonuclease
hydrolysates
possession
postranslational
proteasomal
proteasome
proteasomes
proteolysis
psma1
psma5
psma6
ptm
ribonucleoprotein
rnase
scarcely
spectrometric
tryptic
utr
varies
Tagcloud (Difference)
?
20s
alpha5
alpha6
alpha7
alphal
apparatus
cations
dephosphorylation
electrophoretic
endonuclease
endoribonuclease
hydrolysates
possession
postranslational
proteasomal
proteasome
proteasomes
proteolysis
psma1
psma5
psma6
ptm
ribonucleoprotein
rnase
scarcely
spectrometric
tryptic
utr
varies
Tagcloud (Intersection)
?