DMRT3 and ATP6V0D1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DMRT3	ATP6V0D1
Description		doublesex and mab-3 related transcription factor 3	ATPase H+ transporting V0 subunit d1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosome Lysosomal Membrane Early Endosome Centrosome Synaptic Vesicle Endosome Membrane Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V0 Domain Plasma Membrane Proton-transporting V-type ATPase Complex Axon Terminus Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Protein-containing Complex Binding Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Sex Differentiation Adult Walking Behavior Adult Locomotory Behavior Transmission Of Nerve Impulse Ventral Spinal Cord Interneuron Specification Cell Differentiation Regulation Of Odontogenesis Of Dentin-containing Tooth Male Sex Differentiation	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Vacuolar Transport Vacuolar Acidification Regulation Of Macroautophagy Cell Projection Organization Cellular Response To Increased Oxygen Levels Homeostatic Process Cilium Assembly Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes XBP1(S) activates chaperone genes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs			Tiludronic acid
Diseases
GWAS		Dupuytren's disease ( 28886342) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Response to Homoharringtonine (cytotoxicity) ( 25628645)	Disease progression in age-related macular degeneration ( 29346644) Empathy quotient ( 29527006) Medication use (thyroid preparations) ( 31015401) Refractive error ( 32231278)
Interacting Genes		86 interacting genes: AKAP8L ASPG ATN1 ATP6V0D1 CCNDBP1 CFAP68 CYSRT1 FHL3 FHL5 FOXN1 FRS3 GPSM1 GRN HSF2BP INCA1 KHDRBS3 KPRP KRT31 KRT34 KRT35 KRT36 KRT38 KRT40 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP19-5 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-3 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 LASP1 LMO2 MDFI MEOX2 MGAT5B MID2 MTUS2 MYOZ3 NBPF19 NFKBID NHLRC4 NOTCH2NLA OIP5 PFDN5 PLEKHF2 PLSCR1 PRDM14 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 PSME3 RBPMS REL RFX6 RUSC1 SAT1 SPAG8 TCF4 TLE5 TRAF1 TRIM23 TRIM27 TRIP6 TSC1 TTC19 UBASH3B USP54 WWOX YPEL3 ZFY ZMYND12 ZNF438	10 interacting genes: ADRB2 ATXN1 DMRT3 GATA1 IHO1 IKZF3 LIG4 RBPMS TLE5 TLX3
Entrez ID		58524	9114
HPRD ID		16827	06121
Ensembl ID		ENSG00000064218	ENSG00000159720
Uniprot IDs		Q9NQL9	P61421
PDB IDs			6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Identical Protein Binding Intermediate Filament Organization Structural Molecule Activity Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Binding Epidermis Development	Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Cell Differentiation Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Developmental Process Regulation Of Developmental Process Neuron Fate Specification Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Primary Metabolic Process Regulation Of Bone Mineralization Nucleus Regulation Of Multicellular Organismal Development Nucleobase-containing Compound Biosynthetic Process Regulation Of Gene Expression Transcription By RNA Polymerase II Positive Regulation Of Mini Excitatory Postsynaptic Potential Beta2-adrenergic Receptor Activity Leukocyte Differentiation Basophil Differentiation Eosinophil Fate Commitment Regulation Of Cell Development Mononuclear Cell Differentiation DNA Binding Regulation Of Primitive Erythrocyte Differentiation Regulation Of Cell Differentiation Establishment Of Integrated Proviral Latency Establishment Of Viral Latency Adult Locomotory Behavior Cell Fate Specification Regulation Of Ossification DNA-templated Transcription Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Identical Protein Binding System Development Sequence-specific DNA Binding Primitive Erythrocyte Differentiation Regulation Of Definitive Erythrocyte Differentiation DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination
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