AGFG2 and EPS15L1

Number of citations of the paper that reports this interaction (PMID 9303539)
81

Data Source:
HPRD (in vitro)

		AGFG2	EPS15L1
Gene Name		ArfGAP with FG repeats 2	epidermal growth factor receptor pathway substrate 15-like 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane	Nucleus Plasma Membrane Coated Pit Membrane
	Molecular Function	Molecular_function ARF GTPase Activator Activity Zinc Ion Binding	Calcium Ion Binding Protein Binding
	Biological Process	Biological_process Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity	Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Pathways			Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS			Multiple sclerosis ( 22190364) White blood cell count ( 21738480) White matter integrity ( 23218918)
Protein-Protein Interactions		4 interactors: APP EPS15 EPS15L1 ITSN1	8 interactors: AGFG1 AGFG2 EPN1 GNG5 ITSN1 ITSN2 STON2 TRAPPC2B
Entrez ID		3268	58513
HPRD ID		04932	09445
Ensembl ID		ENSG00000106351	ENSG00000127527
Uniprot IDs		A4D2D6 O95081	Q9UBC2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Endocytosis Vesicle-mediated Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Cell Surface Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Axon Guidance Transport Establishment Of Localization In Cell Signal Transduction Golgi To Endosome Transport Axonogenesis Cellular Copper Ion Homeostasis Signaling Axon Development Cell Communication Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Copper Ion Homeostasis Suckling Behavior Endocytic Recycling Cellular Localization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Projection Morphogenesis Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Morphogenesis Involved In Differentiation Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Clathrin Coat Assembly Synaptic Vesicle Endocytosis Cellular Response To Stimulus RNA Polyadenylation Neuron Recognition Synaptic Vesicle Recycling	Regulation Of Ras GTPase Activity Endocytosis Regulation Of Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Positive Regulation Of Hydrolase Activity Regulation Of ARF GTPase Activity Regulation Of Signal Transduction Regulation Of ARF Protein Signal Transduction Vesicle-mediated Transport Synaptic Vesicle Transport Synaptic Transmission Positive Regulation Of Catalytic Activity Regulation Of Signaling Regulation Of Intracellular Signal Transduction Establishment Of Vesicle Localization Vesicle Localization Cell-cell Signaling Positive Regulation Of Rho GTPase Activity Regulation Of Rho GTPase Activity Regulation Of Catalytic Activity Establishment Of Organelle Localization Regulation Of Rho Protein Signal Transduction Acrosome Assembly Intermediate Filament Organization Transport Organelle Localization Positive Regulation Of Ras GTPase Activity Regulation Of Cellular Process Spermatid Nucleus Differentiation Positive Regulation Of Metabolic Process
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