PTPRR and RYK

Number of citations: 51 (PubMedID 28065597)
Data Source: BioGRID (two hybrid)

		PTPRR	RYK
Name		protein tyrosine phosphatase receptor type R	receptor like tyrosine kinase
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Cell Junction Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Plasma Membrane Membrane Receptor Complex Presynaptic Active Zone Membrane Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Frizzled Binding Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Wnt Receptor Activity
	Biological Process	In Utero Embryonic Development Protein Dephosphorylation Signal Transduction Negative Regulation Of Epithelial Cell Migration ERBB2 Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Homophilic Cell Adhesion	Protein Phosphorylation Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axonogenesis Axon Guidance Synapse Assembly Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neurogenesis Corpus Callosum Development Neuron Differentiation Neuron Projection Development Non-canonical Wnt Signaling Pathway Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of MAPK Cascade Skeletal System Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Negative Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Commissural Neuron Axon Guidance Positive Regulation Of Cell Proliferation In Midbrain Midbrain Dopaminergic Neuron Differentiation
Pathways		None	TCF dependent signaling in response to WNT PCP/CE pathway
GWAS		Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) HDL cholesterol levels ( 32203549 ) Influenza A (H1N1) infection ( 26379185 ) Intraocular pressure ( 29785010 ) Mild influenza (H1N1) infection ( 26379185 ) Monobrow ( 27182965 ) Refractive error ( 23396134 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Uterine fibroids ( 31649266 )	Cadmium levels ( 26025379 ) Diastolic blood pressure ( 27841878 30578418 ) Height ( 31562340 ) Iron status biomarkers (ferritin levels) ( 33536631 ) Systolic blood pressure ( 27841878 28135244 )
Novel Interactors		1 novel interactors: IRS2	None recorded
Interacting Genes		27 interacting genes: AATK CNKSR1 EGFR EPHA2 ERBB2 ERBB3 ERBB4 FGFR2 FGFR4 GABARAPL1 IGF1R INSR KDR LMTK2 MAPK1 MAPK3 MAPK7 MST1R NTRK1 PRKACA PTK7 RET ROR1 ROR2 RYK SNCA TEK	8 interacting genes: EPHB2 EPHB3 FZD8 PPM1B PPP3CA PTPRR WNT1 WNT3A
Entrez ID		5801	6259
HPRD ID		04169	02751
Ensembl ID		ENSG00000153233	ENSG00000163785
Uniprot IDs		B7Z998 Q15256	P34925 Q59FQ5 Q8WTZ8
PDB IDs		2A8B	6TUA
GO Terms Enriched among Interactors		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway ATP Binding Nucleotide Binding Transferase Activity Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Growth Factor Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Autophosphorylation ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Regulation Of ERK1 And ERK2 Cascade Signal Transduction Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Phosphate-containing Compound Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Coreceptor Activity Positive Regulation Of Cell Migration Regulation Of Cell Population Proliferation Animal Organ Development Epidermal Growth Factor Receptor Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Motility Positive Regulation Of Locomotion ERBB Signaling Pathway Regulation Of Multicellular Organismal Process Membrane	Regulation Of Cell Adhesion Lymphocyte Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Dermatome Development Wnt-Frizzled-LRP5/6 Complex Leukocyte Activation Cell Proliferation In Midbrain Inner Ear Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Projection Morphogenesis Regulation Of Cell Projection Organization Neuron Projection Morphogenesis Cell Activation Roof Of Mouth Development Protein Dephosphorylation Axon Guidance Receptor Activity Spinal Cord Association Neuron Differentiation Canonical Wnt Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Midbrain Dopaminergic Neuron Differentiation Ephrin Receptor Activity Signaling Receptor Binding Dendritic Spine Development Transmembrane-ephrin Receptor Activity Urogenital System Development Negative Regulation Of Nervous System Development Regulation Of Multicellular Organismal Process Regulation Of Neuron Projection Development Dendritic Spine Morphogenesis Negative Regulation Of Neurogenesis Regulation Of Nervous System Development Dephosphorylation Phosphoprotein Phosphatase Activity Positive Regulation Of Embryonic Development Regulation Of Axonogenesis Corpus Callosum Development Positive Regulation Of Lymphocyte Proliferation Axonal Fasciculation Neuron Projection Fasciculation Positive Regulation Of Mononuclear Cell Proliferation Retinal Ganglion Cell Axon Guidance Axonogenesis Regulation Of Synapse Assembly Positive Regulation Of Leukocyte Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Central Nervous System Projection Neuron Axonogenesis Negative Regulation Of Cell Projection Organization Negative Regulation Of Multicellular Organismal Process Dendritic Spine Organization