PTPRR

Name	protein tyrosine phosphatase receptor type R
Structure
Novel Interactors	1 novel interactors: IRS2
Interactors	27 interactors: AATK CNKSR1 EGFR EPHA2 ERBB2 ERBB3 ERBB4 FGFR2 FGFR4 GABARAPL1 IGF1R INSR KDR LMTK2 MAPK1 MAPK3 MAPK7 MST1R NTRK1 PRKACA PTK7 RET ROR1 ROR2 RYK SNCA TEK
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	In Utero Embryonic Development Protein Dephosphorylation Signal Transduction Negative Regulation Of Epithelial Cell Migration ERBB2 Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Homophilic Cell Adhesion
GWAS	Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) HDL cholesterol levels ( 32203549 ) Influenza A (H1N1) infection ( 26379185 ) Intraocular pressure ( 29785010 ) Mild influenza (H1N1) infection ( 26379185 ) Monobrow ( 27182965 ) Refractive error ( 23396134 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Uterine fibroids ( 31649266 )
Entrez ID	5801
HPRD ID	04169
Ensembl ID	ENSG00000153233
Uniprot IDs	B7Z998 Q15256
PDB IDs	2A8B
GO Terms Enriched among Interactors ?	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway ATP Binding Nucleotide Binding Transferase Activity Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Growth Factor Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Autophosphorylation ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Regulation Of ERK1 And ERK2 Cascade Signal Transduction Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Phosphate-containing Compound Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Coreceptor Activity Positive Regulation Of Cell Migration Regulation Of Cell Population Proliferation Animal Organ Development Epidermal Growth Factor Receptor Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Motility Positive Regulation Of Locomotion ERBB Signaling Pathway Regulation Of Multicellular Organismal Process Membrane