ZNF410 and OSM

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		ZNF410	OSM
Description		zinc finger protein 410	oncostatin M
Image
GO Annotations	Cellular Component	Nucleus Chromosome	Extracellular Region Extracellular Space
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Transcription Coregulator Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Signaling Receptor Binding Cytokine Activity Oncostatin-M Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Oxygen Transport Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Acute Inflammatory Response Immune Response Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Interleukin-17 Production Positive Regulation Of Peptidyl-serine Phosphorylation Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Hematopoietic Stem Cell Differentiation
Pathways			Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions
Drugs
Diseases
GWAS		Serum uric acid levels ( 29559957)	Coronary artery disease ( 29212778 33020668) Delirium ( 29631748) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233) Myocardial infarction ( 33532862) Nephropathy ( 21399633) Suicidal ideation ( 30145303) Tonsillectomy ( 27941131)
Interacting Genes		54 interacting genes: ABHD8 APP BANP BLZF1 CCNG2 CDKN2A CEP70 CSNK2B DPEP2NB DVL2 FAM9B FHL2 FSD2 GOLGA2 GOLGA6L9 HOXB2 IQUB IRAK1BP1 KRT40 LIMS1 LMO2 LMO4 LNX2 LRIF1 MEOX1 MEOX2 MID2 MTUS2 NDUFAB1 NOSIP OSM PAX6 PDE4DIP PICK1 PNMA1 POGZ POLR2G POLR2M POU6F2 PPM1K PPP1R16B PRKAR1B RAB3IP RASSF3 RCN1 RPRD1A SERTAD1 TRAF2 TRIM35 TSGA10 UHRF2 VBP1 ZNF24 ZNF397	13 interacting genes: APP COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 IL6ST LIFR OSMR S100P TNNT1 ZNF410
Entrez ID		57862	5008
HPRD ID		18339	01300
Ensembl ID		ENSG00000119725	ENSG00000099985
Uniprot IDs		Q53FM1 Q86VK4	B5MCX1 P13725
PDB IDs		6WMI	1EVS 8V29 8V2A
Enriched GO Terms of Interacting Partners?		Segment Specification Nucleus Cytoplasm Identical Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Somite Specification	Collagen Type IV Trimer Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Signaling Pathway Collagen Trimer Basement Membrane Extracellular Matrix Structural Constituent Oncostatin-M Receptor Activity Endoplasmic Reticulum Lumen Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Binding Extracellular Matrix Organization Extracellular Structure Organization Enzyme-linked Receptor Protein Signaling Pathway Extracellular Region Extracellular Matrix Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Complex Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Cell Surface Receptor Signaling Pathway Cytokine Binding Growth Factor Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Cytokine Receptor Activity Receptor Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Glomerular Basement Membrane Development Cell Body Transition Metal Ion Binding External Side Of Plasma Membrane Positive Regulation Of Acute Inflammatory Response Integrin Binding Positive Regulation Of Inflammatory Response Signal Transduction Cell Junction Organization Neuromuscular Junction Development Regulation Of Acute Inflammatory Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Cytokine Slow-twitch Skeletal Muscle Fiber Contraction Response To Peptide Synapse Organization Regulation Of Cell Population Proliferation Acetylcholine Receptor Activator Activity Lipoprotein Particle
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